A5025816379- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Hydrogels: synthesis, properties, applications
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Advanced Polymer Synthesis and Characterization
- 3D Printing in Biomedical Research
- Photodynamic Therapy Research Studies
- Magnolia and Illicium research
- Advanced Nanomaterials in Catalysis
- Immune cells in cancer
- Wound Healing and Treatments
- Virus-based gene therapy research
- Advancements in Transdermal Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Polymer Surface Interaction Studies
- Extracellular vesicles in disease
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
State Key Laboratory of Biotherapy
2016-2025
Sichuan University
2016-2025
Tianjin Centers for Disease Control and Prevention
2017-2025
Tianjin Special Equipment Supervision and Inspection Technology Research Institute
2025
Jiangsu Province Hospital
2008-2024
Nanjing Medical University
2008-2024
Southeast University
2023
Zhejiang Hospital
2022
West China Hospital of Sichuan University
2009-2022
Shenzhen Bay Laboratory
2022
Curcumin is an effective and safe anticancer agent, but its hydrophobicity inhibits clinical application. Nanotechnology provides method to improve the water solubility of hydrophobic drug. In this work, curcumin was encapsulated into monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles through a single-step nano-precipitation method, creating curcumin-loaded MPEG-PCL (Cur/MPEG-PCL) micelles. These Cur/MPEG-PCL were monodisperse (PDI = 0.097 ± 0.011) with mean particle...
The therapeutic outcome of photothermal therapy (PTT) remains impeded by the transparent depth light. Combining PTT with immunotherapy provides strategies to solve this problem. Regulating metabolism-related enzymes is a promising strategy stimulate immune response. Here, nanosystem (NLG919/IR780 micelles) properties conversion and regulation tryptophan metabolic pathway used suppress growth tumor margin beyond effective promote immunotherapy. It revealed that mild heat treatment promotes...
Nanocarriers with positive surface charges are known for their toxicity which has limited clinical applications. The mechanism underlying toxicity, such as the induction of inflammatory response, remains largely unknown. In present study we found that injection cationic nanocarriers, including liposomes, PEI, and chitosan, led to rapid appearance necrotic cells. Cell necrosis induced by nanocarriers is dependent on charges, but does not require RIP1 Mlkl. Instead, intracellular Na+ overload...
Three-dimensional (3D) printing technology has great potential in advancing clinical medicine. Currently, the vivo application strategies for 3D-printed macroscale products are limited to surgical implantation or situ 3D at exposed trauma, both requiring exposure of site. Here, we show a digital near-infrared (NIR) photopolymerization (DNP)-based that enables noninvasive bioprinting tissue constructs. In this technology, NIR is modulated into customized pattern by micromirror device, and...
The combination of chemotherapy with photodynamic therapy (PDT) has attracted broad attention as it can overcome limitations conventional chemo-treatment by using different modes action. However, the efficacy PDT to treat solid tumors is severely affected hypoxia in tumors.
On-demand release of carbon monoxide (CO) is realized through a novel near-infrared-responsive nanomedicine in favor the enhancement therapy efficacy and biosafety CO therapy. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: The publisher...
Abstract The combination of chemotherapy and photodynamic therapy (PDT) has promising potential in the synergistic treatment cancer. However, are impeded by uncontrolled chemotherapeutics release behavior, targeting deficiencies, hypoxia‐associated poor PDT efficacy solid tumors. Here, a platinum nanozyme (PtNP) loaded reactive oxygen species (ROS)‐responsive prodrug nanoparticle (CPT‐TK‐HPPH/Pt NP) is created to overcome these limitations. ROS‐responsive consists thioketal bond linked with...
Gold nanorods (GNRs) are well known in photothermal therapy based on near-infrared (NIR) laser absorption of the longitudinal plasmon band.Herein, we developed an effective stimulus system --GNRs and doxorubicin co-loaded polymersomes (P-GNRs-DOX) --to facilitate co-therapy chemotherapy.DOX can be triggered to release once corrupted under local hyperthermic condition GNRs induced by NIR irradiation.Also, cytotoxicity caused residual cetyltrimethylacmmonium bromide (CTAB) was reduced...
Abstract For breast cancer patients who have undergone breast‐conserving surgery, effective treatments to prevent local recurrences and metastases is very essential. Here, a injectable therapeutic platform based on thermosensitive PLEL hydrogel with near‐infrared (NIR)‐stimulated drug release developed achieve synergistic photothermal immunotherapy for prevention of postoperative relapse. Self‐assembled multifunctional nanoparticles (RIC NPs) are composed three components including...
Abstract In this study, a series of injectable thermoreversible and thermogelling PDLLA-PEG-PDLLA copolymers were developed systematic evaluation the system both in vitro vivo was performed. The aqueous solutions above critical gel concentration could transform into hydrogel spontaneously within 2 minutes around body temperature or . Modulating molecular weight, block length polymer adjust sol-gel transition behavior mechanical properties hydrogels. gelation thermally reversible due to...
The prevalence of skin cancer is rising along with the rapid population aging in recent years. Traditional therapies, such as surgical treatment, radiotherapy, chemotherapy, photodynamic therapy, and immunotherapy, may accompany serious side effects, limiting their clinical benefits. According to biological characteristics cancer, we have already established two kinds synergetic systems photothermal therapy (microneedle) containing gold nanorods (GNR). Although microneedle system exhibited...
Glioma treatment using targeted chemotherapy is still far from satisfactory due to not only the limited accumulation but also multiple survival mechanisms of glioma cells, including up-regulation both autophagy and programmed cell death ligand 1 (PD-L1) expression. Herein, we proposed a combined therapeutic regimen based on functional gold nanoparticles (AuNPs)-enabled chemotherapy, inhibition, blockade PD-L1 immune checkpoint. Specifically, legumain-responsive AuNPs (D&H-A-A&C) could...
Osteosarcoma is a malignant bone tumor, which often occurs in adolescents. However, surgical resection usually fails to completely remove the tumor clinically, has been main cause of postoperative recurrence and metastasis, resulting high death rate patients. At same time, osteosarcoma invades large area defect, cannot be self-repaired seriously affects life quality Herein, bifunctional methacrylated gelatin/methacrylated chondroitin sulfate hydrogel hybrid gold nanorods (GNRs)...
Abstract The wide clinical application of photodynamic therapy (PDT) is hampered by poor water solubility, low tumor selectivity, and nonspecific activation photosensitizers, as well hypoxia which common for most solid tumors. To overcome these limitations, tumor‐targeting, redox‐activatable, oxygen self‐enriched theranostic nanoparticles are developed synthesizing chlorin e6 (Ce6) conjugated hyaluronic acid (HA) with reducible disulfide bonds (HSC) encapsulating perfluorohexane (PFH) within...