A5049740688- Single-cell and spatial transcriptomics
- Advanced biosensing and bioanalysis techniques
- Gas Sensing Nanomaterials and Sensors
- Advanced Chemical Sensor Technologies
- Extracellular vesicles in disease
- GNSS positioning and interference
- Analytical Chemistry and Sensors
- Cancer Genomics and Diagnostics
- Microfluidic and Bio-sensing Technologies
- Geophysics and Gravity Measurements
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Gut microbiota and health
- Spinal Fractures and Fixation Techniques
- Biosensors and Analytical Detection
- Cancer-related molecular mechanisms research
- Genetic Neurodegenerative Diseases
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ionosphere and magnetosphere dynamics
- Epigenetics and DNA Methylation
- Electrowetting and Microfluidic Technologies
- Gene expression and cancer classification
- Advanced Frequency and Time Standards
Renji Hospital
2019-2025
Shanghai Jiao Tong University
2015-2025
Henan Provincial People's Hospital
2018-2025
Guangxi Normal University
2025
State Key Laboratory of Oncogene and Related Genes
2020-2025
Zhengzhou University
2018-2025
University of Science and Technology of China
2022-2025
Jiangxi Science and Technology Normal University
2025
Space Micro (United States)
2025
Zunyi Medical University
2025
Curcumin is an effective and safe anticancer agent, but its hydrophobicity inhibits clinical application. Nanotechnology provides method to improve the water solubility of hydrophobic drug. In this work, curcumin was encapsulated into monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles through a single-step nano-precipitation method, creating curcumin-loaded MPEG-PCL (Cur/MPEG-PCL) micelles. These Cur/MPEG-PCL were monodisperse (PDI = 0.097 ± 0.011) with mean particle...
The World Health Organization has declared the outbreak of a novel coronavirus (SARS-CoV-2 or 2019-nCoV) as global pandemic. However, mechanisms behind infection are not yet fully understood, nor there any targeted treatments vaccines. In this study, we identified high-binding-affinity aptamers targeting SARS-CoV-2 RBD, using an ACE2 competition-based aptamer selection strategy and machine learning screening algorithm. Kd values optimized CoV2-RBD-1C CoV2-RBD-4C against RBD were 5.8 nM 19.9...
Abstract Immunotherapy has revolutionized cancer treatment, but its efficacy is severely hindered by the lack of effective predictors. Herein, we developed a homogeneous, low‐volume, efficient, and sensitive exosomal programmed death‐ligand 1 (PD‐L1, type transmembrane protein) quantitation method for diagnosis immunotherapy response prediction (HOLMES‐Exo PD‐L1 ). The combines newly evolved aptamer that efficiently binds to with less hindrance antigen glycosylation than antibody,...
The ubiquitous biomembrane interface, with its dynamic lateral fluidity, allows membrane-bound components to rearrange and localize for high-affinity multivalent ligand-receptor interactions in diverse life activities. Inspired by this, we herein engineered a fluidic nanointerface decorating microfluidic chip aptamer-functionalized leukocyte membrane nanovesicles high-performance isolation of circulating tumor cells (CTCs). This biomimetic active recruitment-binding afforded significant...
A closely packed hybrid electrocatalyst Pt 1.5 Ni 1− x /Ni–N–C was engineered by a gas-promoted dealloying process, ensuring the relay catalysis of reaction intermediates at alloy and single sites, thus achieving high performance in PEMFCs.
Arranging atoms in an orderly manner at the atomic scale to create stable polyatomic structures is a very challenging task. In this study, we have developed three-dimensional confinement areas on two-dimensional surface by creating regional defects. These are composed of vertically stacked graphene layers, where Ni and Fe anchored concentrically form axial dual sites high yield. can be used produce tunable syngas through electroreduction CO2. Theoretical calculations indicate that regulate...
Rational regulation of the three-dimensional (3D) intrinsic configuration nanocatalysts is essential for complex three-phase interfacial mass transfer process in oxygen reduction reaction (ORR) and proton membrane exchange fuel cells (PEMFCs). In this work, we developed a highly efficient 3D hierarchical porous ORR catalytic system by introducing stable multiaperture zirconia (ZrO2) conductive N-doped carbon (NC) into Pt-based catalyst. We found that constructed Pt–ZrO2 interface greatly...
Macrophages have an affinity to developing tumors and been shown play a role in tumor combat immune surveillance. However, the exact mechanism by which macrophages participate anti-tumor response remains unclear. Hence, current study aimed identify effect of on gastric cancer (GC) cells via exosomes. Paired cancerous, tumor-adjacent, non-cancerous stomach tissues were initially from 68 GC patients. T isolated peripheral blood mononuclear (PBMCs) obtained both patients as well healthy donors....
Nanofibers have attracted increasing attention in drug delivery and other biomedical applications due to their some special properties. The present study aims prepare a fiber-based nanosolid dispersion system enhance the bioavailability of curcumin (CUR). CUR-loaded polyvinyl pyrrolidone (CUR@PVP) nanofibers were successfully prepared via electrospinning. Scanning electron microscopy (SEM) was employed observe morphology nanofibers, SEM image showed that drug-loaded smooth, no CUR clusters...
Abstract Microfluidic chips with nano‐scale structures have shown great potential, but the fabrication and cost issues restrict their application. Herein, we propose a conceptually new “DNA nanolithography in microfluidic chip” by using sub‐10 nm three‐dimensional DNA (TDNs) as frameworks pendant aptamer at top vertex (ApTDN‐Chip). The framework ensures that is highly ordered upright orientation, avoiding undesired orientation or crowding effects caused conventional interface processes....
Triple-negative breast cancer (TNBC) is an aggressive subset of and currently lacks effective therapeutic targets. As two main phototherapeutic methods, photothermal therapy (PTT) photodynamic (PDT) show many advantages in TNBC treatment, their combination with chemotherapy can achieve synergistic effects. In the present study, a biomimetic nanoplatform was developed based on leukocyte/platelet hybrid membrane (LPHM) dendritic large pore mesoporous silicon nanoparticles (DLMSNs). A near...
With the completion of Chinese BeiDou Navigation Satellite System (BDS), world has begun to enjoy Positioning, Navigation, and Timing (PNT) services four Global Systems (GNSS). In order improve GNSS performance expand its applications, Low Earth Orbit (LEO) Enhanced (LeGNSS) is being vigorously advocated. Combined with high-, medium-, low- earth orbit satellites, it can in terms determination, Precise Point Positioning (PPP) convergence time, etc. This paper comprehensively reviews current...
The orderly assembly of single atoms into highly periodic aggregates at the nanoscale is an intriguing but challenging process high-precision atomic manufacturing. Here, we discover that in-plane film surface shrinkage can induce molecular self-assembly to arrange with unconventional distribution, contributing them one-dimensional segregation on carbon stripes (one-dimensional single-atom arrays (SAA)). This originates from fact metal phthalocyanine (MPc) molecules gradually aggregate and...
The clinical potential of miRNA-based liquid biopsy has been largely limited by the heterogeneous sources in plasma and tedious assay processes. Here, we develop a precise robust one-pot called dual-surface-protein-guided orthogonal recognition tumor-derived exosomes situ profiling microRNAs (SORTER) to detect exosomal miRNAs enhance diagnostic accuracy prostate cancer (PCa). SORTER uses two allosteric aptamers against marker CD63 tumor EpCAM create an labeling barcode achieve selective...
Abstract Polygenic risk scores (PRS) have the potential to identify individuals at of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using multi-center six populations (6 059 NPC cases 7 582 controls), evaluate its utility in nested case-control study. We show that enables effective identification high-risk (AUC = 0.65) improves prediction with incremental...
Abstract Single-cell RNA sequencing (scRNA-seq) reveals the transcriptional heterogeneity of cells, but static snapshots fail to reveal time-resolved dynamics transcription. Herein, we develop Well-TEMP-seq, a high-throughput, cost-effective, accurate, and efficient method for massively parallel profiling temporal single-cell gene expression. Well-TEMP-seq combines metabolic labeling with scRNA-seq Well-paired-seq distinguish newly transcribed RNAs marked by T-to-C substitutions from...
Abstract Single-cell and spatial transcriptome sequencing, two recently optimized sequencing methods, are increasingly used to study cancer related diseases. Cell annotation, particularly for malignant cell is essential crucial in-depth analyses in these studies. However, current algorithms lack accuracy generalization, making it difficult consistently rapidly infer cells from pan-cancer data. To address this issue, we present Cancer-Finder, a domain generalization-based deep-learning...