A5100437849- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Magnolia and Illicium research
- Synthesis and biological activity
- Chromatography in Natural Products
- Histone Deacetylase Inhibitors Research
- Natural product bioactivities and synthesis
- Protein Degradation and Inhibitors
- Metal-Organic Frameworks: Synthesis and Applications
- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects of Natural Compounds
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Crystallography and molecular interactions
- Oxidative Organic Chemistry Reactions
- Bioactive Compounds and Antitumor Agents
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Nanoparticle-Based Drug Delivery
- Acute Lymphoblastic Leukemia research
State Key Laboratory of Biotherapy
2016-2025
Sichuan University
2016-2025
East China University of Technology
2020-2025
Ministry of Natural Resources
2024-2025
Zhengzhou University
2014-2025
Henan Cancer Hospital
2015-2025
South China University of Technology
2011-2025
Northwest Women's and Children's Hospital
2022-2025
Northwest Institute of Eco-Environment and Resources
2017-2024
Chinese Academy of Sciences
2008-2024
The combination of chemotherapy with photodynamic therapy (PDT) has attracted broad attention as it can overcome limitations conventional chemo-treatment by using different modes action. However, the efficacy PDT to treat solid tumors is severely affected hypoxia in tumors.
Quercetin is a potent chemotherapeutic drug. Clinical trials exploring different schedules of administration quercetin have been hampered by its extreme water insolubility. To overcome this limitation, study aimed to develop liposomal and investigate distribution in vivo antitumor efficacy vitro.Quercetin was encapsulated polyethylene glycol 4000 liposomes. Biodistribution i.v. at 50 mg/kg tumor-bearing mice detected high-performance liquid chromatography. Induction apoptosis vitro tested....
Abstract The potential antidiabetic activity of ethyl acetate extract the leaves Lagerstroemia speciosa (LSL) was investigated by α ‐amylase and ‐glucosidase inhibition assay. Six pentacyclic triterpenes (oleanolic acid, arjunolic asiatic maslinic corosolic acid 23‐hydroxyursolic acid) were isolated from LSL. Their structures determined spectroscopic analysis their ‐glycosidase inhibitory activities investigated. They exhibited no or weak against middle activities. Corosolic which shows best...
Abstract Receptor-like kinases play important roles in plant development and defense responses; however, their functions other processes remain unclear. Here, we report that OsSIK2, an S-domain receptor-like kinase from rice (Oryza sativa), is involved abiotic stress the senescence process. OsSIK2 a plasma membrane-localized protein with activity presence of Mn2+. expressed mainly leaf sheath can be induced by NaCl, drought, cold, dark, abscisic acid treatment. Transgenic plants...
Background Gliosarcoma is one of the most common malignant brain tumors, and anti-angiogenesis a promising approach for treatment gliosarcoma. However, chemotherapy obstructed by physical obstacle formed blood-brain barrier (BBB) blood-cerebrospinal fluid (BCSFB). Honokiol has been known to possess potent activities in central nervous system diseases, anti-angiogenic anti-tumor properties. Here, we hypothesized that honokiol could cross BBB BCSFB Methodologies We first evaluated abilities...
Abstract Exosomes are small endogenous membrane vesicles that can mediate cell communication by transferring genetic materials. Based on that, exosomes have always been discussed as a cargo carrier for microRNA (miRNA) transportation. Accumulating data reported the inhibitory effects of microRNA-193a (miR-193a) non-small lung cancer (NSCLC) progression. However, mechanisms miR-193a delivery to cells and in not explored clearly NSCLC. Given this work aims decode exosomal cisplatin (DDP)...
The high-mobility group box protein 1 (HMGB1) is increasingly recognized as an important inflammatory mediator. In some cases, the release of HMGB1 regulated by poly(ADP-ribose) polymerase-1 (PARP-1), but mechanism still unclear. this study, we report that PARP-1 activation contributes to LPS-induced PARylation HMGB1, insufficient direct its migration from nucleus cytoplasm; regulates translocation cytoplasm through upregulating acetylation HMGB1. mouse bone marrow-derived macrophages,...
In this paper, a series of novel 4-substituted coumarin derivatives were synthesized. Among these compounds 34, 39, 40, 43, 62, 65, and 67 exhibited significant antiproliferative activity toward panel tumor cell lines at subnanomolar IC50 values. Compound 65 showed potent ability (IC50 values 7-47 nM) retained full in multidrug resistant cancer cells. caused G2/M phase arrest interacted with the colchicine-binding site tubulin, as confirmed by immune-fluorescence staining, microtubule...
Benefiting from the maximum atom-utilization efficiency and distinct structural features, single-atom catalysts open a new avenue for design of more functional catalysts, whereas their bioapplications are still in infancy. Due to advantages, platinum single atoms supported by cadmium sulfide nanorods (Pt SAs-CdS) synthesized build an ultrasensitive photoelectrochemical (PEC) biosensing platform. With decoration Pt SAs, PEC signal CdS is significantly boosted. Furthermore, theory calculations...
Copper-mediated selective mono- or diaryloxylation of benzamides has been achieved by using 2-aminopyridine 1-oxide as a new and removable N,O-bidentate directing group. The reaction system shows broad substrate scope provides straightforward way for the synthesis diaryloxylated benzoic acids.
Novel selective histone deacetylase 6 (HDAC6) inhibitors using the quinazoline as cap were designed, synthesized, and evaluated for HDAC enzymatic assays. N-Hydroxy-4-(2-methoxy-5-(methyl(2-methylquinazolin-4-yl)amino)phenoxy)butanamide, 23bb, was most potent inhibitor HDAC6 with an IC50 of 17 nM showed 25-fold 200-fold selectivity relative to HDAC1 HDAC8, respectively. In vitro, 23bb presented low nanomolar antiproliferative effects against panel cancer cell lines. Western blot analysis...
Molecules that alter the normal dynamics of microtubule assembly and disassembly include many anticancer drugs in clinical use. So far all such therapeutics target β-tubulin, structural biology has explained basis their action permitted design new drugs. However, by shifting profile β-tubulin isoforms, cancer cells become resistant to treatment. Compounds bind α-tubulin are less well characterized unexploited. The natural product pironetin is known a potent inhibitor polymerization. Previous...
Mesenchymal stem cell (MSC)-based therapies have been used in skin regeneration due to their ability differentiate into many cells, promote cytokine secretion and participate collagen deposition.In this study, we concluded that a CuS@BSA nanoparticles exhibited similar potential inducing MSCs differentiation fibroblasts as Cu ions for wound healing.Methods: First, verified the photothermal efficiency of vivo vitro had no cytotoxicity when temperature was controlled at 42 °C by adjusting...
Abstract Background Worldwide feralization of crop species into agricultural weeds threatens global food security. Weedy rice is a feral form that infests paddies worldwide and aggressively outcompetes cultivated varieties. Despite increasing attention in recent years, comprehensive understanding the origins weedy relatives how universal process acts at genomic molecular level to allow rapid adaptation weediness are still yet be explored. Results We use whole-genome sequencing examine origin...
Abstract Objectives To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/respiratory intensive care units (MICUs/RICUs) to assess ventilation management use adjunct therapy routine clinical practice for patients fulfilling Berlin definition ARDS mainland China. Methods This was a multicentre prospective longitudinal study. Patients who met were included. Baseline data on ventilator collected. Results Of 18,793 admitted participating ICUs during...
Abstract Background Cancer cachexia is a multifactorial metabolic syndrome in which bile acid (BA) metabolism might be involved. The aim of the present study was to clarify contribution liver and gut microbiota BA disturbance cancer check possibility targeting using agents such as tauroursodeoxycholic (TUDCA) for therapy. Methods profiles liver, intestine, serum mice with induced by inoculation colon C26 tumour cells were analysed metabolomics methods compared that control mice. Proteomic...
This study aims to explore the relevance of anoikis in idiopathic pulmonary fibrosis (IPF) and identify associated biomarkers signaling pathways.