A5101956362- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Forensic and Genetic Research
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Cancer therapeutics and mechanisms
- Protein Degradation and Inhibitors
- Nanoparticle-Based Drug Delivery
- Phytochemical Studies and Bioactivities
- Natural product bioactivities and synthesis
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Synthesis and biological activity
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Genetic diversity and population structure
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Flavonoids in Medical Research
- Metabolomics and Mass Spectrometry Studies
- Acupuncture Treatment Research Studies
Sichuan University
2016-2025
State Key Laboratory of Biotherapy
2017-2025
West China Medical Center of Sichuan University
2012-2024
West China Hospital of Sichuan University
2016-2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2013-2019
Union Hospital
2019
Huazhong University of Science and Technology
2019
Chengdu University
2018
The University of Texas MD Anderson Cancer Center
2009
In this paper, a series of novel 4-substituted coumarin derivatives were synthesized. Among these compounds 34, 39, 40, 43, 62, 65, and 67 exhibited significant antiproliferative activity toward panel tumor cell lines at subnanomolar IC50 values. Compound 65 showed potent ability (IC50 values 7-47 nM) retained full in multidrug resistant cancer cells. caused G2/M phase arrest interacted with the colchicine-binding site tubulin, as confirmed by immune-fluorescence staining, microtubule...
Genome-wide association studies have identified that genetic variants in 8q24 confer susceptibility to colorectal cancer (CRC). Recently, a novel lncRNA (PRNCR1) located the was discovered. Single nucleotide polymorphisms (SNPs) lncRNAs may influence process of splicing and stability mRNA conformation, resulting modification its interacting partners. We hypothesized SNPs PRNCR1 be related risk CRC.We conducted case-control study genotyped five tag 908 subjects including 313 cases with CRC...
Selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitors not only exhibit antitumor efficacy but also offer the potential to mitigate toxicities typically associated with broader PARP inhibition. In this study, we designed and synthesized a series of small molecules targeting highly selective PARP1 inhibitors. Among these, T26 demonstrated excellent selectivity along capability effectively cross blood-brain barrier (BBB). exhibited an IC50 0.2 nM against PARP1, remarkable 610-fold over...
A combination treatment strategy that relies on the synergetic effects of different therapeutic approaches has been considered to be an effective method for cancer therapy. Herein, a chemotherapeutic drug (doxorubicin, Dox) and manganese ion (Mn2+) were co-loaded into regenerated silk fibroin-based nanoparticles (NPs), followed by surface conjugation phycocyanin (PC) construct tumor microenvironment-activated nanococktails. The resultant PC-Mn@Dox-NPs showed increased release rates...
Abstract Fruit color substantially affects consumer preferences, with darker red strawberries being economically more valuable due to their higher anthocyanin content. However, the molecular basis for dark coloration remains unclear. Through screening of an ethyl methanesulfonate mutant library, we identified a rg418 mutant, that demonstrated accumulation during early fruit development stages. Furthermore, ripening fruits this had content than wild-type (WT) fruits. An analysis flavonoid in...
For decades, microtubules—composed of αβ-tubulin dimers—have been primary targets for cancer chemotherapy. While eight binding sites on the tubulin dimer have structurally characterized, this study reveals a ninth. We found that inhibitor Tumabulin-1 (TM1, BML284 derivative) binds simultaneously to well-known colchicine site and previously unknown site, designated as Tumabulin site. This resides at interface α1-tubulin, β1-tubulin, RB3 within tubulin–RB3–tubulintyrosine ligase complex....
Abstract Rhizoma Paridis, a traditional Chinese medicine, has shown promise in cancer prevention and therapy. In the present study, we isolated Paris Saponin I (PSI), an active component of paridis, evaluated its effects on panel human cell lines mouse model ovarian to explore mechanisms activity. PSI had more potent selective cytotoxic tumor than etoposide had, promoting dramatic G2-M phase arrest apoptosis SKOV3 cells time- dose-dependent manner. Furthermore, treatment increased levels...
Esophageal carcinoma is the sixth most common cause of cancer-related mortality in world. Senescence and apoptosis are assumed to be two main mechanisms that inhibit age-related carcinogenesis. p14ARF, p15INK4b p16INK4a, which known induce senescence by regulating G1 cell cycle arrest, have been identified as markers. However, mechanism causes neoplasia esophageal squamous (ESCC) has not identified. In this study, 20 cases normal tissues, 11 intraepithelial dysplasia (EID) 60 ESCC were...
Abstract The miR-34 family members, described as potential tumor suppressors, were downregulated in colorectal cancer (CRC). Loss of impairs TP53 -mediated cell death, while overexpression induces apoptosis. A potentially functional polymorphism (i.e., rs4938723T/C) the promoter region pri-miR-34b/c was predicted to influence GATA-X binding sites. We aimed investigate association between miR-34b/c rs4938723 and Arg72Pro polymorphisms risk CRC. genotyped two 347 CRC patients 488 healthy...
A long ncRNA (lncRNA) prostate cancer non-coding RNA 1 (PRNCR1) in the 8q24 has been reported to be upregulated with a function of activating androgen receptor (AR). AR plays key role gender disparity, cell migration, and invasion gastric (GC). We hypothesized that single nucleotide polymorphisms (SNPs) lncRNA PRNCR1 may related risk GC. conducted case-control study investigate association between SNPs Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was...
Herein, we describe the design, synthesis, and structure–activity relationships of a series unique 4-(1H-pyrazol-4-yl)-pyrimidin-2-amine derivatives that selectively inhibit Janus kinase 2 (JAK2) FLT3 kinases. These screening cascades revealed 18e was preferred compound, with IC50 values 0.7 4 nM for JAK2 FLT3, respectively. Moreover, potent inhibitor 37-fold 56-fold selectivity over JAK1 JAK3, respectively, possessed an excellent profile other 100 representative In cytokine-stimulated...
So far, relatively few small molecules have been reported to promote tubulin degradation. Our previous studies found that compound 2, a noncovalent colchicine-site ligand, was capable of promoting αβ-tubulin To further improve its antiproliferative activity, 66 derivatives or analogues 2 were designed and synthesized based on 2-tubulin cocrystal structure. Among them, 12b displayed nanomolar potency against variety tumor cells, including paclitaxel- adriamycin-resistant cell lines. binds the...
NF-kB can function as an oncogene or tumor suppressor depending on cancer types. The role of in low-grade serous ovarian cancer, however, has never been tested. We sought to elucidate the cancer.The cell line, HOC-7, derived from a papillary carcinoma. Introduction dominant negative mutant, IkBαM, which resulted decrease lines. transcription ability, tumorigenesis, proliferation and apoptosis were observed derivative lines comparison with parental cells.Western blot analysis indicated...