Genome-wide association studies have identified that genetic variants in 8q24 confer susceptibility to colorectal cancer (CRC). Recently, a novel lncRNA (PRNCR1) located the was discovered. Single nucleotide polymorphisms (SNPs) lncRNAs may influence process of splicing and stability mRNA conformation, resulting modification its interacting partners. We hypothesized SNPs PRNCR1 be related risk CRC.We conducted case-control study genotyped five tag 908 subjects including 313 cases with CRC...

Purpose: With the advance of screening techniques, there is a growing number low-risk or intermediate-risk prostate cancer (PCa) cases, remaining serious threat to men’s health. To obtain better efficacy, interest has been attracted develop such emerging treatments as immunotherapy and focal therapy. However, few studies offer guidance on whether how combine these modalities against PCa. This study was designed dual-functional nanoparticles (NPs) which combined photothermal therapy (PTT)...

Abstract MicroRNA (miR)-143 and miR-145 have been identified as molecular regulators in cell proliferation, growth, clone formation, apoptosis, cycle, invasion, migration. We previously found that rs353292 the flanking region of miR-143/145 showed a high frequency patients with colorectal cancer (CRC). To identify whether polymorphism is risk factor for CRC, we conducted this study larger samples. A total 809 CRC 1005 gender matched controls were collected. The was genotyped by using TaqMan...

Porcine reproductive and respiratory syndrome (PRRS) is caused by the PRRS virus (PRRSV). It leads to disorders failure in sows piglets. As an endoribonuclease, PRRSV non-structural protein 11 (NSP11) crucial replication assists immune system evasion. NSP11, which relatively more conserved than NSP2, could potentially cause a new round of epidemics, given major mutation occurs. Here, we aimed analyze PRRSV-2 NSP11 genetic diversity China between 1996‒2022. The nucleotide sequence was...

Tumor suppressor p53 directly regulated the abundance of miR-34b/c. The interaction might contribute to certain cancer. We hypothesized that rs4938723 in promoter region pri-miR-34b/c and TP-53 Arg72Pro may be related risk papillary thyroid carcinoma (PTC). A total 784 patients with PTC 1006 healthy controls were recruited participate this study. variants discriminated using a polymerase chain reaction–restriction fragment length polymorphism method (PCR-RFLP). Additionally, relative...

MiR-143/145 is down-regulated in cervical cancer, which may serve as a tumor suppressor by targeting KRAS and Ras-responsive element-binding protein (RREB1). Activated leads to down-regulation of miR-143/145 transcription RREB1-dependent manner, establishing miR-143/145-KRAS-RREB1 feedback loop. A polymorphism rs4705343C/T the promoter might influence binding TATA-binding protein. We hypothesized that rs4705343 rs712 be related occurrence squamous cell carcinoma (CSCC). In this study, we...

Growing evidence has indicated that polymorphism present in the miRNA binding site of target gene can alter ability miRNAs to bind its and modulate development progression cancer. We aimed investigate association between let-7 KRAS rs712 risk colorectal cancer (CRC). The was analyzed a case-control study, including 339 CRC patients 313 age- sex-matched controls; relationship clinicopathological features also examined. Individuals carrying TT genotype T allele had an increased developing (TT...

A long ncRNA (lncRNA) prostate cancer non-coding RNA 1 (PRNCR1) in the 8q24 has been reported to be upregulated with a function of activating androgen receptor (AR). AR plays key role gender disparity, cell migration, and invasion gastric (GC). We hypothesized that single nucleotide polymorphisms (SNPs) lncRNA PRNCR1 may related risk GC. conducted case-control study investigate association between SNPs Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was...

Previous studies have demonstrated that miR-34 family members are abnormally expressed in gastric cancer. Overexpression of the suppresses carcinogenesis, whereas downregulation promotes tumorigenesis. p53 can bind to promoter region miR-34b/c, leading an increase miR-34b/c expression. Recently, a variant pri-miR-34b/c (rs4938723) has been discovered, with function altering binding efficiency transcription factor GATA. The purpose this study was examine role rs4938723 and TP53 Arg72Pro...

Abstract Background MicroRNAs (miRNAs) play an important regulatory role in carcinogenesis and cancer progression. Aberrant expression of miR‐497‐5p has been reported various human malignancies. However, the hepatocellular carcinoma (HCC) remains unclear. Results In this study, we found that was downregulated HCC tissues. The low level tumors correlated with aggressive clinicopathological characteristics predicted poor prognosis patients. overexpression significantly inhibited cell...

miR-34 family members can form a p53-miR-34 positive feedback loop and induce apoptosis, DNA repair, angiogenesis, cell cycle arrest. We conducted case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c TP53 Arg72Pro) were linked carcinogenesis cervical cancer among Chinese Han women. Genotypes 328 patients 568 control subjects determined by using polymerase chain reaction—restriction fragment length polymorphism assay. found significantly...

The incidence and mortality rates of lung cancer rank top in the different types cancers China. Licochalcone A (LA) is a flavonoid extracted from roots licorice with antitumor effects various vitro vivo. However, role LA non-small cell (NSCLC) remains largely unclear.The viability was measured by MTT assay, Edu staining colony formation assay. Apoptosis investigated using Annexin V/PI double-stained assays flow cytometry. Real-time quantitative RT-PCR carried out to investigate expression...

In the present study, due to complex and numerous targets of Sarcandrae Herb (also known as Zhong Jie Feng), network pharmacology was performed analyze its therapeutic effect on 2 cervical cancer cell lines, which could assist with development novel therapies. The results suggested that natural flavonoid quercetin (Que), effective antitumor ingredient in SH, is widely a variety plants, may depend target, EGFR. Previous studies have shown EGFR serves crucial role occurrence cancer, but...

Abstract Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, but early diagnosis rate low. The RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in several cancers its mechanism action LUAD unclear. In this study, biological activity was assessed LUAD. and RUNX3 mRNA levels tissues patients were determined using reverse transcription‑quantitative PCR. involvement growth metastasis cells measured by EdU assay, CCK-8, colony formation, Transwell TUNEL, flow...

miR-17-92 cluster is identified as a potential oncogenic miRNA. The aim of this study was to investigate the association polymorphisms in promoter region with risk colorectal cancer (CRC). Three (i.e., rs9588884, rs982873 and rs1813389) were analyzed among 874 cases 1132 controls using TaqMan allelic discrimination assay or polymerase chain reaction-restriction fragment length polymorphism method. Relative expression examined CRC tumors noncancerous tissues quantitative reverse...

IL-12 is an antitumor cytokine with functions of inhibiting tumor growth, invasion, and metastasis, indicating that a promising candidate for cancer treatment. The aim this study was to investigate the association IL-12A rs568408, rs2243115, IL-12B rs3212227 susceptibility colorectal (CRC). Two hundred fifty-seven histopathologically confirmed CRC patients 236 age- gender-matched controls were enrolled. three polymorphisms genotyped using polymerase chain reaction-restriction fragment length...

This study aimed to assess whether an insertion/deletion polymorphic variation rs28362491 in the NFKB1 promoter region was related risk of papillary thyroid carcinoma (PTC). Genomic DNA extracted from peripheral venous blood 352 patients with PTC and 459 controls. The polymorphism genotyped by using a polymerase chain reaction assay. We found that frequency heterozygous genotype ATTG1/ATTG2 significantly higher cases compared controls (odds ratios [OR]=1.44, 95% confidence intervals...

Lung cancer is the leading cause of cancer-related death worldwide and non-small cell lung (NSCLC) represents 85%. Mougeotia nummuloides Spirulina major have been reported to possess anticancer properties. 1-Monopalmitin (1-Mono) principle active constituent in these natural plants. It debating whether 1-Mono exerts antitumor effects. Therefore, we explored role vitro. Results showed that significantly inhibited A549 SPC-A1 proliferation, induced G2/M arrest caspase-dependent apoptosis....

The aim of this study was to investigate the effect a polymorphism rs4705341 in flanking region miR-143/145 on risk colorectal cancer (CRC). analyzed 1002 cases and 1062 controls using polymerase chain reaction-restriction fragment length method. We found significantly reduced CRC susceptibility with homozygote comparison (adjusted OR = 0.66, 95%CI, 0.50-0.88, P 0.004), dominant genetic model 0.80, 0.67-0.96, 0.015), recessive 0.73, 0.56-0.94, 0.016), allele 0.83, 0.73-0.94, 0.004)....