A5100602406- Neural dynamics and brain function
- stochastic dynamics and bifurcation
- Neuroscience and Neuropharmacology Research
- Cancer-related Molecular Pathways
- Gene Regulatory Network Analysis
- Nonlinear Dynamics and Pattern Formation
- RNA Research and Splicing
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Neural Networks and Applications
- Cancer-related molecular mechanisms research
- Neuroscience and Neural Engineering
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Cancer Research and Treatments
- Ion channel regulation and function
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Cancer Cells and Metastasis
- Optimization and Search Problems
- Lung Cancer Treatments and Mutations
- Photoreceptor and optogenetics research
Nanjing University
2014-2024
Collaborative Innovation Center of Advanced Microstructures
2009-2024
Shanghai Jiao Tong University
2006-2024
Shandong Provincial QianFoShan Hospital
2011-2024
Shandong University
2012-2024
Hunan Normal University
2024
Hunan Provincial People's Hospital
2021-2024
Beihang University
2024
Shaanxi Institute of International Trade & Commerce
2019-2024
Suzhou Kowloon Hospital
2024
The tumor suppressor p53 mainly induces cell cycle arrest/DNA repair or apoptosis in the DNA damage response. How to choose between these two outcomes is not fully understood. We proposed a four-module model of signaling network and associated dynamics with cellular after ionizing radiation. found that response mediated by both level posttranslational modifications activated progressive manner. First, partially primary such as phosphorylation at Ser-15/20 induce arrest, its varying series...
Estrogen, in addition to its genomic effects brain, causes rapid and reversible changes synaptic operations. We report here that these acute actions are due selective activation of an actin-signaling cascade normally used the production long-term potentiation (LTP). or a agonist steroid's β-receptor, caused modest increase fast glutamatergic transmission pronounced facilitation LTP adult hippocampal slices; both were completely eliminated by latrunculin, toxin prevents actin filament...
The tumor suppressor p53 plays a crucial role in cellular response to various stresses. Recent experiments have shown that level exhibits series of pulses after DNA damage caused by ionizing radiation (IR). However, how the govern cell survival and death remains unclear. Here, we develop an integrated model with four modules for network explore mechanism fate decision based on dynamics network. By numerical simulations, following processes are characterized. First, repair proteins bind...
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) enhance <i>N</i>-methyl-d-aspartate function and may represent a novel approach for the treatment schizophrenia. ADX47273 [<i>S</i>-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-methanone], recently identified potent selective mGlu5 PAM, increased (9-fold) response to threshold concentration (50 nM) in fluorometric Ca<sup>2+</sup> assays (EC<sub>50</sub> = 170 human...
Dopamine, by activating dopamine D1-type receptors, and adenosine, adenosine A 2A stimulate phosphorylation of DARPP-32 (dopamine- cAMP-regulated phosphoprotein M r 32,000) at Thr-34. In this study, we investigated the effect metabotropic glutamate (mGlu) receptors on Thr-34 in neostriatal slices. broad-spectrum mGlu receptor agonist, trans -ACPD, a group I DHPG, stimulated Studies with antagonists revealed that effects -ACPD DHPG were mediated through activation mGlu5 receptors. The action...
Positive and negative feedback loops are often coupled to perform various functions in gene regulatory networks, acting as bistable switches, oscillators, excitable devices. It is implied that such a system with interlinked positive flexible motif can modulate itself among functions. Here, we developed minimal model for the systematically explored its dynamics performance advantage response stimuli unifying framework. The indeed displays diverse behaviors when strength of changed. First, be...
Cyclin-dependent kinase 5 (Cdk5) is a multifunctional neuronal protein that required for neurite outgrowth and cortical lamination plays an important role in dopaminergic signaling the neostriatum through phosphorylation of Thr-75 DARPP-32 (dopamine cAMP-regulated phosphoprotein, molecular mass 32 kDa). Casein 1 (CK1) has been implicated variety cellular functions such as DNA repair, circadian rhythm, intracellular trafficking. In neostriatum, CK1 found to phosphorylate Ser-137 DARPP-32....
Propagation of the firing rate and synchronous firings in a 10-layer feed-forward neuronal network are studied. When neurons layer 1 subject to white noise, synchrony can be built up deep layers propagated. A with 6 is found enough for such behavior. periodic signal frequencies 30--80 Hz selectively transmitted through network. These abilities information processing due modulated by noise operating mode neurons, our results relevant experimental findings.
Secretory clusterin (sCLU) is expressed in numerous cancers and associated with the resistance to chemotherapy. However, role of sCLU hepatocellular carcinoma (HCC) oxaliplatin (OXA), a recently used third-generation platinum agent, remains unclear. The stable transfectants that are depleted or overexpress OXA-resistant cells were generated using human HCC cells. Overexpression abrogated OXA-induced inhibition cell growth apoptosis, but depletion synergized OXA inhibit enhance by regulating...
BMP9 induces both osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs). Nell1 is a secretory glycoprotein with osteoinductive anti-adipogenic activities. We investigated the role in BMP9-induced osteogenesis adipogenesis MSCs.Previously characterized MSCs iMEFs were used. Overexpression NELL1 or silencing mouse was mediated by adenoviral vectors. Early late markers assessed staining techniques qPCR analysis. In vivo activity an ectopic bone formation model athymic...
Abstract Large skin wounds, with extensive surface area and deep vertical full‐thickness involvement, can pose significant challenges in clinical settings. Traditional routes for repairing wounds encompass three hallmarks: 1) scab formation hemostasis; 2) proliferation migration of epidermal cells wound closure; 3) proliferation, migration, functionalization fibroblasts endothelial dermal remodeling. However, this route face remarkable to healing large usually leading disordered structures...
Previously, we reported that (<i>S</i>)-3,5-dihydroxypenylglycine (DHPG), an agonist for group I metabotropic glutamate receptors (mGluRs), stimulates CK1 and Cdk5 kinase activities in neostriatal neurons, leading to enhanced phosphorylation, respectively, of Ser-137 Thr-75 DARPP-32 (dopamine cAMP-regulatedphosphoprotein, 32 kDa). We have now investigated the signaling pathway leads from mGluRs casein 1 (CK1) activation. In mouse slices, effect DHPG on phosphorylation or was blocked by...
After DNA damage, cells must decide between different fates including growth arrest, repair, and apoptosis. Both p53 E2F1 are transcription factors involved in the decision process. However, mechanism for cross-talk pathways still remains unclear. Here, we proposed a four-module kinetic model of process explored interplay these two response to ionizing radiation via computer simulation. In our levels separately exhibit pulsatile switching behaviors. Upon is first activated, whereas...
ABSTRACT There is accumulating evidence that, from bacteria to mammalian cells, messenger RNAs (mRNAs) are produced in intermittent bursts – a much ‘noisier’ process than traditionally thought. Based on quantitative measurements at individual promoters, diverse phenomenological models have been proposed for transcriptional bursting. Nevertheless, the underlying molecular mechanisms and significance cellular signalling remain elusive. Here, we review recent progress, address above issues...