Abstract Background Hidden blood loss (HBL) represents an important complication of unilateral biportal endoscopic (UBE) spine surgery. This study aimed to evaluate HBL and its possible risk factors among patients undergoing UBE surgery for lumbar degenerative diseases. Methods multicentric retrospective was conducted in 3 different medical centers between July 2020 April 2021. Data who underwent were extracted by electronic record system. The patient’s demographic characteristics...

Purpose: Machine Learning (ML) is rapidly growing in capability and increasingly applied to model outcomes complications medicine. Surgical site infections (SSI) are a common post-operative complication spinal surgery. This study aimed develop validate supervised ML algorithms for predicting the risk of SSI following minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). Methods: single-central retrospective included total 705 cases between May 2012 October 2019. Data patients...

Making timely assessments of disease progression in patients with COVID-19 could help offer the best personalized treatment. The purpose this study was to explore an effective model predict outcome COVID-19. We retrospectively included 188 (124 training set and 64 test set) diagnosed Patients were divided into aggravation improvement groups according progression. Three kinds models established, including radiomics, clinical, combined model. Receiver operating characteristic curves, decision...

The purpose of this study was to develop and validate a predictive model based on machine learning (ML) approach identify patients with DKA at increased risk AKI within 1 week hospitalization in the intensive care unit (ICU).Patients diagnosed from Medical Information Mart for Intensive Care IV (MIMIC-IV) database according International Classification Diseases (ICD)-9/10 code were included. patient's medical history is extracted, along data their demographics, vital signs, clinical...

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide; however, current treatment options are inadequate, necessitating exploration new therapeutic strategies. The microbiota significantly influences tumor...

Colorectal cancer (CRC) is a common malignancy requiring early screening to improve patient outcomes. Current methods such as colonoscopy and fecal occult blood tests have several limitations including high cost, poor specificity, invasiveness, inconvenience. Recent research has identified specific bacterial communities associated with CRC, notably Parvimonas micra (P. micra), which serves biomarker for diagnosis owing its accumulation in the malignant tissues feces of CRC patients. Herein,...

Colorectal cancer (CRC) ranks as the third most prevalent globally, both in terms of diagnoses and cancer-related mortality. Increasing evidence suggests that an imbalance intestinal flora can contribute to progression CRC, fecal microbiota may serve potential biomarkers for its screening diagnosis. Notably, Porphyromonas gingivalis has been identified malignant tissues feces CRC patients, establishing it a significant biomarker early screening, diagnosis, prognostic assessment CRC. Current...

Colorectal cancer (CRC) is one of the most common cancers; however, accurately predicting prognosis based on existing molecular subtypes remains challenging. The XELOX regimen, which combines oxaliplatin and capecitabine, cornerstone chemotherapy for CRC treatment. However, there a notable lack reliable predictive models determining sensitivity this This study aimed to establish novel classification system develop model chemotherapeutic using serum metabolomics. We recruited 89 patients with...

Mucosal healing (MH) has established as a long-term therapeutic goal for inflammatory bowel disease (IBD). Regenerative Islet-derived Protein 1α (reg1α) was reported to be closely related gastrointestinal mucosal injury; however, its potential in monitoring MH remains unexplored. Serum reg1α levels were quantified 156 consecutive IBD patients (January 2021-December 2023) and stratified by endoscopic findings into (n = 136) non-mucosal (NMH) groups. Diagnostic performance of evaluated...

The objective of our project is to explore a noninvasive radiomics model based on magnetic resonance imaging (MRI) that could recognize the expression vascular endothelial growth factor (VEGF) in hepatocellular carcinoma before operation.202 patients with proven single HCC were enlisted and stochastically distributed into training set (n = 142) test 60). Arterial phase, portal venous balanced delayed hepatobiliary phase images used features extraction. We retrieved 1906 radiomic from each...

More and more evidences show that the imbalance of intestinal flora homeostasis can contribute to progression colorectal cancer (CRC). Solobacterium moorei (S. moorei), an anaerobic Gram-positive bacillus, was found be enriched in fecal samples from CRC patients. However, signaling regulatory mechanism S. promoting remain unknown. Three mouse models (ApcMin/+ mice, AOM/DSS-treated mice subcutaneous xenograft mice) two cell lines (DLD-1 HT-29) were used investigate biological functions...

Breath analysis using gas sensors is an emerging method for disease screening and diagnosis. Since it closely related to the lipid metabolism blood ketone concentration of body, detection acetone content in exhaled breath helpful monitoring diabetes ketosis. The development sensor with high selectivity, stability, low limit has been research focus this purpose. Here, we developed a mixed potential type based on Gd2Zr2O7 solid electrolyte CoSb2O6 sensing electrode. exhibits extremely 10 ppb,...

This study aimed to develop and validate a nomogram for predicting acute kidney injury (AKI) during the Intensive Care Unit (ICU) stay of patients with diabetic ketoacidosis (DKA).A total 760 diagnosed DKA from Medical Information Mart III (MIMIC-III) database were included randomly divided into training set (70%, n = 532) validation (30%, 228). Clinical characteristics data utilized establish prediction AKI ICU stay. The least absolute shrinkage selection operator (LASSO) regression was...

This study aimed to predict C5 palsy (C5P) after posterior laminectomy and fusion (PLF) with cervical myelopathy (CM) from routinely available variables using a support vector machine (SVM) method.We conducted retrospective investigation based on 184 consecutive patients CM PLF, data were collected March 2013 December 2019. Clinical imaging obtained imported into univariable multivariable logistic regression analyses identify risk factors for C5P. According published reports clinical...

Background: This study aimed to develop and validate a nomogram for predicting mortality in patients with thoracic fractures without neurological compromise hospitalized the intensive care unit. Methods: A total of 298 from Medical Information Mart Intensive Care III (MIMIC-III) database were included study, 35 clinical indicators collected within 24 h patient admission. Risk factors identified using least absolute shrinkage selection operator (LASSO) regression. multivariate logistic...

Background: Microvascular bifurcation asymmetry is of significance for regulation coronary flow heterogeneity during juvenile and adult growth. The aim the study to investigate morphometric hemodynamic variation arterial bifurcations in mice different ages. Methods: Pulsatile blood flows were computed from a Womersley-type model reconstructed left (LCA) trees Micro-CT images normal at ages 3 weeks, 6 12 5-6 months, >8 months. Diameter ratios angles determined each LCA trees. Results: volume...

Vertebral artery (VA) stenosis is relevant to a high early risk of recurrent stroke and basilar (BA) the most common intracranial site atherosclerotic lesions. It important show predictive factors for transient ischemic attack (TIA) or posterior infarctions. The aim study investigate morphometry hemodynamics in vertebral arteries health diseased patients enhance assessment. Based on geometrical model reconstructed from CTA images 343 patients, three-dimensional computational was used...

Abstract There is higher long‐term failure of the saphenous vein graft ( SVG ) compared with left internal mammary artery LIMA graft, which affected by hemodynamic environment. A comprehensive analysis postoperative structure‐function changes important to study atherogenesis in . comparison morphometric and parameters was carried out between grafts s different time points postoperatively. Various were obtained from image reconstruction flow simulation patients, who underwent CT exams for ~1...

Acquired myasthenia (AM), a debilitating autoimmune disease, is typically characterized by skeletal muscle fatigue and weakness. Despite advances in gravis treatment, current approaches remain unsatisfactory many result unexpected side effects. Traditional Chinese medicine has shown great potential the treatment of gravis, including relieving myasthenic symptoms, improving patients' quality life, reducing Western This study investigates protective effects mechanism BZYQD mice with acquired...