A5103249986- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Diseases and Immunity
- Viral Infections and Vectors
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- COVID-19 Clinical Research Studies
- Liver physiology and pathology
- Animal Virus Infections Studies
- Skin and Cellular Biology Research
- Viral Infections and Outbreaks Research
- Traditional Chinese Medicine Analysis
- Vector-Borne Animal Diseases
- Cardiac Valve Diseases and Treatments
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Hair Growth and Disorders
- Natural product bioactivities and synthesis
- Neuroblastoma Research and Treatments
- Advanced Drug Delivery Systems
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
Nanjing Drum Tower Hospital
2016-2025
Key Laboratory of Guangdong Province
2024
Third Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Nanjing University
2021-2024
Cell Technology (China)
2024
Huizhou Central People's Hospital
2024
Chinese Academy of Agricultural Sciences
2022-2023
Shanxi Medical University
2023
Chengdu University of Traditional Chinese Medicine
2020-2022
Abstract A substantial proportion of patients with chronic hepatitis B (CHB) who do not fit into any the usual immune states are considered to be in ‘grey zone (GZ)’. We aimed investigate distribution and characteristics GZ a large cohort CHB patients. Four thousand seven hundred fifty‐nine consecutive treatment‐naïve were enrolled. The defined based on AASLD 2018 Hepatitis Guidance. classified four groups: HBeAg positive, normal ALT levels serum HBV DNA ≤10 6 IU/ml (GZ‐A); elevated ≤2 × 10...
Summary Background Many patients with chronic hepatitis B (CHB) do not meet the definitions of traditional natural phases and are classified as being in grey zone (GZ). Aims To investigate liver histology, to establish a management strategy for CHB GZ. Methods This study included 1043 who underwent biopsy. Phases history were determined according AASLD 2018 guidance. GZ divided into HBeAg‐positive, normal ALT HBV DNA ≤10 6 IU/ml (GZ‐A); elevated ≤2 × 10 4 (GZ‐B); HBeAg‐negative, ≥2 3 (GZ‐C)...
Liver biopsies are recommended to exclude significant liver inflammation in patients with chronic hepatitis B (CHB) elevated HBV DNA but without other indications for antiviral treatment. We aimed investigate the proportions and determinants of Asian CHB detectable DNA. conducted a cross‐sectional study that retrospectively included 581 who had undergone biopsy. fibrosis were staged by Scheuer’s classification. Significant defined as G ≥ 2 S 2, respectively. There 179 (30.8%) alanine...
Background: The upper limits of normal (ULNs) for alanine aminotransferase (ALT) are different among international guidelines chronic hepatitis B (CHB). We aimed to investigate the proportion significant histological disease in Asian patients with CHB detectable virus (HBV) DNA under diverse ALT ULNs. Methods: Consecutive and HBV who underwent liver biopsy were retrospectively included from four tertiary hospitals. Above grade 2 inflammation stage fibrosis defined as fibrosis, respectively....
Leflunomide as an immunosuppressive drug is generally used in the treatment of rheumatoid arthritis. It inhibits DHODH (dihydroorotate dehydrogenase ), which one essential enzymes de novo pyrimidine biosynthetic pathway. Here we showed that leflunomide significantly reduced cell proliferation and self-renewal activity. Annexin V-FITC/PI staining assay revealed induced S-phase cycle arrest, promoted apoptosis. In vivo xenograft study SCID mice inhibited tumor growth development. We also...
ABSTRACT The exclusion of cirrhosis is important in chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT). We aimed to optimise the performance aspartate platelet ratio index (APRI) and fibrosis score based on four factors (FIB‐4) exclude these patients. Five hundred eighty ALT who underwent liver biopsy were included study. divided into derivation external validation sets. A grid search method was used identify new cut‐offs a negative predictive value (NPV) > 95%...
Abstract The gamma-glutamyl transpeptidase to platelet ratio (GPR) is a novel index estimate liver fibrosis in chronic hepatitis B (CHB). Few studies compared diagnostic accuracy of GPR with other non-invasive tests based on blood parameters. We analyzed values for detecting and performances APRI (aspartate aminotransferase-to-platelet index), FIB-4 (fibrosis the four factors), NLR (neutrophil-to-lymphocyte ratio), AAR aminotransferase/alanine aminotransferase ratio) RPR (red cell...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging epidemic infectious disease caused by the SFTS bunyavirus (SFTSV) estimated high case-fatality rate of 12.7% to 32.6%. Currently, has been reported in mainland China, Japan, Korea, and United States. At present, there no specific antiviral therapy for SFTSV infection. Considering higher mortality rapid clinical progress SFTS, supporting appropriate treatment time patients critical. Therefore, it very important clinicians...
Bloodstream infection (BSI) caused by Klebsiella pneumoniae (KP), especially carbapenem-resistant KP (CRKP), results in high morbidity and mortality.We aim to identify risk factors that associated with the mortality of patients BSI, as well predictors developing CRKP BSI.In this retrospective cohort study, we examined 285 inpatients BSI a tertiary hospital China between 2014 2018, 46 were infected CRKP. We identified hematological tumor (odds ratio (OR): 8.359, [95% CI: 2.162-33.721],...
Abstract Introduction As an emerging infectious disease, coronavirus disease 2019 (COVID‐19) has rapidly spread throughout worldwide. Health care workers (HCWs) on frontline directly participated in the diagnosis, treatment, and of COVID‐19 patients are at high risk getting infected with highly severe acute respiratory syndrome 2 (SARS‐CoV‐2), novel that causes COVID‐19. In Nanjing Drum Tower Hospital, a total 222 medical staff went to Wuhan city for support. this study, we aimed determine...
Noninvasive models have been established for the assessment of liver fibrosis in patients with chronic hepatitis B(CHB). However, predictive performance these remains inconclusive. We aimed to develop a novel model CHB based on routinely clinical parameters.Platelets(PLT), standard deviation red blood cell distribution width(RDW-SD), alkaline phosphatase(ALP) and globulin were independent predictors significant by multivariable analysis. Based parameters, new namely...
Deleterious mutations play an important functional role, affecting trait phenotypes in ways that decrease the fitness of organisms. Estimating frequency occurrence and abundance has been a topic much interest, especially crops livestock. The processes domestication breeding allow deleterious to persist at high frequency, identifying such is particularly for breed improvement. Here, we assessed genome-wide patterns variation 59 domestic 13 wild yaks using genome resequencing data. Based on...
Red blood cell distribution width (RDW) was reported to be associated with the severity of liver diseases. We aimed investigate association between RDW and inflammation in autoimmune hepatitis (AIH).Ninety-two consecutive AIH patients who underwent biopsy during 2016-2017 were included. Liver histology evaluated using Scheuer scoring system. Logistic regression analysis used analyze risk factors for significant inflammation. The diagnostic accuracy by area under receiver operating...
Serum hepatitis B surface antigen (HBsAg) level < 100 IU/ml and undetectable virus (HBV) DNA have been recently proposed as an alternate endpoint of "partial cure" in chronic (CHB). We investigated clinical outcomes e (HBeAg)-negative CHB patients with HBsAg <100 HBV DNA. Treatment-naïve HBeAg-negative normal alanine aminotransferase were retrospectively included from three institutions. Patients classified into the low group (<100 IU/ml) high (≥100 IU/ml). Liver fibrosis was evaluated by...