A5063515035- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Prostate Cancer Diagnosis and Treatment
- Xenotransplantation and immune response
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Pelvic floor disorders treatments
- Vascular Procedures and Complications
- Bacterial Identification and Susceptibility Testing
- Central Venous Catheters and Hemodialysis
- Dialysis and Renal Disease Management
- Organ and Tissue Transplantation Research
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Healthcare Policy and Management
- Transplantation: Methods and Outcomes
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Urinary Bladder and Prostate Research
- Diabetes and associated disorders
Brown University
2014-2023
Miriam Hospital
2023
Rhode Island Hospital
2023
Tufts University
2019-2021
St. Elizabeth's Medical Center
2019-2020
Massachusetts General Hospital
2008-2017
Harvard University
2001-2016
Suffolk University
2014
NHS Blood and Transplant
2007
Harvard University Press
2005
Background. Delayed graft function (DGF) is frequently observed in recipients of cadaveric renal transplants. Previous retrospective or nonrandomized studies have suggested that intraoperative administration polyclonal antithymocyte preparations may reduce the incidence DGF, possibly by decreasing ischemia-reperfusion injury. Methods. We performed a prospective randomized study Thymoglobulin induction therapy adult transplant recipients. Between January 2001 and 2002, 58 were to receive...
Expanded criteria donors (ECDs) and donation after cardiac death (DCD) provide more kidneys in the donor pool. However, financial impact long-term benefits of these have been questioned. From 1998 to 2005, we performed 271 deceased kidney transplants into adult recipients. There were 163 (60.1%) SCDs, 44 (16.2%) ECDs, 53 (19.6%) DCDs 11 (4.1%) ECD/DCDs. The mean follow-up was 50 months. ECD DCD had a significantly higher incidence delayed graft function, longer time reach serum creatinine...
Background. Compared with standard donors, kidneys recovered from donors after cardiac death (DCD) exhibit higher rates of delayed graft function (DGF), and DCD livers demonstrate biliary ischemia, loss, worse patient survival. Current practice limits the use these organs based on time donor extubation to asystole, but data support this is incomplete. We hypothesized that postextubation parameters, including duration severity hemodynamic instability or hypoxia might be a better predictor...
To retrospectively assess the accuracy of four-section multi-detector row computed tomography (CT) in evaluation renal transplant donors when scans are read by one multiple readers with varied levels expertise, using surgery as reference standard.This retrospective study was approved institutional review board and complied Health Insurance Portability Accountability Act. Informed consent waived. Between October 1999 March 2003, 94 (42 men, 52 women; mean age, 44 years) underwent CT....
Donation after cardiac death (DCD) has proven effective at increasing the availability of organs for transplantation.We performed a retrospective examination Massachusetts General Hospital (MGH) records all 201 donors from 1/1/98 to 11/2008, including 54 DCD, 115 DBD and 32 DCD candidates that did not progress donation (DCD-dnp). Comparing three time periods, era 1 (01/98-12/02), 2 (01/03-12/05) 3 (01/06-11/08), DCD’s comprised 14.8,48.4% 60% donors, respectively (p = 0.002). A significant...
We correlated multichannel pressure-flow urodynamics and the American Urological Association (AUA) symptom index in evaluation of benign prostatic hyperplasia.We evaluated 121 consecutive, symptomatic patients older than 55 years with AUA score urodynamic studies. Testing was performed during a single session data obtained from 103 were plotted on Schäfer nomogram for assessment outflow obstruction. Linear regression statistical analysis used to determine correlations.There no significant...
Purpose: Develop real-world evidence that rapid identification of uropathogens and susceptibilities improves urologic outcomes for patients with complicated or history recurrent urinary tract infections (r/cUTIs). Standard urine culture (SUC) is slow, often missing polymicrobial altered antibiotic resistance from their metabolic interactions. Materials Methods: We compared 1-year UTI-related health care utilization costs UTIs diagnosed by outpatient multiplex polymerase chain reaction/pooled...
Shortage of deceased donors is a severe problem in recent years China especially culture which brain death criteria not widely accepted. Donation after cardiac (DCD) has been reported to expand the donor pool despite higher rates primary nonfunction (PNF) and delayed graft function (DGF) transplantation. We collected 71 DCD kidney transplants performed at our hospital between February, 2007 June, 2012 with aims demonstrate feasibility donation China. All patients were followed up,...
We have previously reported successful induction of transient mixed chimerism and long-term acceptance renal allografts in MHC mismatched nonhuman primates. In this study, we attempted to extend tolerance approach islet allografts. A total eight recipients underwent combined bone marrow (BM) transplantation after diabetes by streptozotocin. Three were treated a nonmyeloablative conditioning regimen that included low-dose body thymic irradiation, horse Atgam (ATG), six doses anti-CD154...
Studies have shown that multiple genes influence antibiotic susceptibility, but the relationship between genotypic and phenotypic susceptibility is unclear. We sought to analyze concordance presence of resistance (ABR) results in urine samples collected from patients with symptomatic urinary tract infection (UTI). Urine were presenting 37 geographically disparate urology clinics across United States July 2018 February 2019. Multiplex polymerase chain reaction was used detect 27 ABR genes. In...
Recent advances in islet cell transplantation have led to insulin independence a majority of transplant recipients. However, there exists need overcome the shortage donor tissue and necessity for life-long immunosuppression. Preclinical studies large animal models are necessary evaluate safety efficacy alternative approaches clinical transplantation. The nonhuman primate serves as an appropriate model such investigations; however, major impediment performing preclinical research has been...