Abstract Background Most models determining how patient and caregiver characteristics costs change with Alzheimer's disease (AD) progression focus on one aspect, for example, cognition. AD is inadequately defined by a single domain; tracking focusing aspect may mean other important aspects are insufficiently addressed. Dependence has been proposed as better marker following progression. Methods This was cross‐sectional observational study (18 UK sites). Two hundred forty‐nine community or...

OBJECTIVES We evaluated the effects of treatment on health-related quality life (HRQoL) during a randomized controlled trial natalizumab maintenance therapy (ENACT-2) using both disease-specific and generic measures. METHODS Crohn's disease patients who received as induction in ENACT-1 (N = 724) responded 339) were re-randomized to ENACT-2 which they 300 mg 168) or placebo 171) every 4 wk for 48 additional wk. Outcome measures change from baseline inflammatory bowel questionnaire (IBDQ),...

Purpose: Develop real-world evidence that rapid identification of uropathogens and susceptibilities improves urologic outcomes for patients with complicated or history recurrent urinary tract infections (r/cUTIs). Standard urine culture (SUC) is slow, often missing polymicrobial altered antibiotic resistance from their metabolic interactions. Materials Methods: We compared 1-year UTI-related health care utilization costs UTIs diagnosed by outpatient multiplex polymerase chain reaction/pooled...

To assess medical resource utilization associated with Prader-Willi syndrome (PWS) in the US, hypothesized to be greater relative a matched control group without PWS.We used retrospective case-matched design and longitudinal US administrative claims data (MarketScan) during 5-year enrollment period (2009-2014). Patients PWS were identified by Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code 759.81. Controls on age, sex, payer type. Outcomes included total,...

Summary Background : Tegaserod is a promotility agent with proven efficacy and safety in patients irritable bowel syndrome constipation. Aim To assess tegaserod's effect on work productivity daily activity. Methods Women, 18–65 years old meeting Rome II criteria for constipation, were randomized to double‐blind, placebo‐controlled, multicentre study of tegaserod 6 mg b.d. or placebo. Productivity loss activity impairment because measured the Work Activity Impairment questionnaire syndrome,...

Multiple sclerosis (MS) patients experience lower health-related quality of life (HRQoL) than the general population. In clinical trials, natalizumab significantly improved HRQoL and reduced relapse rates disability progression in with relapsing MS. a 1-year analysis included current study, improvement occurred within 3 months initiation continued for 1 year thereafter. However, natalizumab's long-term efficacy improving has not been studied.In this longitudinal, observational, single-arm US...

Phlebolymphedema (chronic venous insufficiency-related lymphedema) is a common and costly condition. Nevertheless, there dearth of evidence comparing phlebolymphedema therapeutic interventions. This study sought to examine the medical resource utilization phlebolymphedema-related cost associated with Flexitouch (FLX; Tactile Medical, Minneapolis, Minn) advanced pneumatic compression devices (APCDs) relative conservative therapy (CONS) alone, simple (SPCDs), other APCDs in representative U.S....

Baseline data are summarized from a study examining the psychometric properties of Neuropsychological Test Battery (NTB) and its subtests, correlating NTB with other cognitive functional assessments. A multicenter, longitudinal, non-interventional included mild to moderate Alzheimer’s disease (AD, n = 196), impairment (MCI, 70), or normal cognition participants (NC, 75). The NTB, assessment tools, functional/behavioral questionnaires, health outcome assessments were administered. At baseline...

We evaluate the association between caregiver (informal) time/cost and illness severity from two recently completed clinical trials of an investigational drug for Alzheimer's disease (AD). Changes baseline time were calculated treatment effects analyzed using a restricted maximum likelihood-based mixed model repeated measures. Four separate models then estimated to examine costs endpoints measured during trials, including cognition (MMSE), function (DAD), behavior (NPI), global disability...

The objective of this study was to define the current forms treatment in a contemporary population lymphedema (LED) patients for LED related breast cancer, most prevalently diagnosed comorbidity Western countries, and phlebolymphedema with venous leg ulcer (PLEDU), sequela chronic disease. goals therapy are reduce edema, thereby improving function symptoms, improve skin integrity prevent development infection. Treatment is generally nonsurgical: conservative care, including complex physical...

To assess the budget impact to a US commercial health plan of providing access Flexitouch (FLX) advanced pneumatic compression device (Tactile Medical) lymphedema (LE) patients with either comorbid chronic venous insufficiency (CVI) or frequent infections.Budget was calculated over 2 years for hypothetical payer 10-million members. Model inputs were derived from published sources and case-matched analysis Blue Health Intelligence (BHI) claims data 2012-2016. calculate impact, Status Quo...

Crohn's disease (CD) is a disabling disorder often requiring hospitalization. This study evaluated the effect of natalizumab (NAT) therapy on hospitalization rates during both induction and maintenance treatment phases three randomized controlled trials. Induction with NAT was studied using pooled data from ENACT-1 ENCORE trials moderate to severe CD patients intravenous 300mg or placebo (PBO) every 4 weeks for 12 weeks. The analysis conducted ENACT-2 trial ENABLE, an open label extension....

e19502 Background: Few elderly patients with RR-DLBCL are offered HSCT and little is known about their overall survival (OS) rates or economic burden. This study evaluated OS healthcare resource utilization (HRU) among Medicare who received HSCT. Methods: Using the Surveillance, Epidemiology, End Results (SEER)-Medicare database, relapsed after receiving R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) as first-line therapy (1L) for DLBCL diagnosed between 2000 2011...

CONCLUSION: HIPAAs' new requirements will demand significant effort and expense for systems business process development. Businesses from the smallest independent pharmacy to largest health plans must be compliant by deadlines imposed HIPAA.

OBJECTIVE: Evaluate the effect of oral delayed-release dimethyl fumarate (DMF) on patient-reported health-related quality life (HRQoL) in RRMS patients with a history treatment interferon beta-1a/1b or glatiramer acetate (GA; prior ABCRE subgroup) no MS (treatment-naïve subgroup), post-hoc analysis integrated data from Phase 3 DEFINE and CONFIRM studies. BACKGROUND: As DMF is first- second-line treatment, it interest to evaluate its HRQoL according therapy. DESIGN/METHODS: Eligibility...

OBJECTIVE: To use patient-reported quality of life measures to evaluate physical functioning in MS patients over 3 years clinical practice. BACKGROUND: In the AFFIRM phase trial, natalizumab was shown improve quality-of-life versus placebo patients. Further research suggests that treated with earlier (NatE) later (NatL) course disease progression may experience less disability time. DESIGN/METHODS: A US longitudinal observational study enrolled initiating treatment. Physical assessed using...

Background: This study sought to examine the real-world impact of multimodality cyclical-pressure topical wound oxygen therapy (TWO2) on hospitalizations and amputations in patients with diabetic foot ulcer (DFU) compared without TWO2.Methods: We conducted a retrospective review deidentified patient medical records at 2 US Veterans Affairs hospitals between January 2012 2020. DFU were assigned TWO2 or NO cohorts based their treatment records. Patients received appropriate standard care may...