A5102955346- Pharmaceutical Practices and Patient Outcomes
- Reproductive Health and Contraception
- Maternal and Perinatal Health Interventions
- Health Systems, Economic Evaluations, Quality of Life
- Global Maternal and Child Health
- Opioid Use Disorder Treatment
- Pain Management and Opioid Use
- Fungal and yeast genetics research
- Plant-Microbe Interactions and Immunity
- Healthcare Policy and Management
- Genetic Mapping and Diversity in Plants and Animals
- Healthcare cost, quality, practices
- Dementia and Cognitive Impairment Research
- Gastric Cancer Management and Outcomes
- Primary Care and Health Outcomes
- MicroRNA in disease regulation
- Intensive Care Unit Cognitive Disorders
- Frailty in Older Adults
- Gut microbiota and health
- Blood Pressure and Hypertension Studies
- Circular RNAs in diseases
- Colorectal Cancer Screening and Detection
- Chronic Disease Management Strategies
- Rice Cultivation and Yield Improvement
- Maternal Mental Health During Pregnancy and Postpartum
VA Pittsburgh Healthcare System
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Jiujiang First People's Hospital
2025
Mianyang Central Hospital
2014-2024
Shenyang Agricultural University
2010-2024
University of Electronic Science and Technology of China
2024
The First People’s Hospital of Lianyungang
2013-2023
Heilongjiang University of Chinese Medicine
2023
Shanghai University of Traditional Chinese Medicine
2011-2022
Zhejiang Hospital
2019-2022
Examine age-adjusted odds and racial/ethnic differences in self-reported difficulties falling staying asleep early morning awakening midlife women to determine whether difficulty sleeping increased with progression through the menopausal transition.Longitudinal analysis.Community-based.3,045 Caucasian, African American, Chinese, Japanese, Hispanic women, aged 42-52 years pre- or peri-menopausal at baseline, participating Study of Women's Health Across Nation (SWAN).None.Self-reported number...
Abstract Objective: To examine sexual function in a cohort of Baby Boomer women diverse racial/ethnic backgrounds; to compare differences between pre-and early perimenopausal women; and identify sociodemographic, health-related, psychosocial (including psychological, behavioral, relationship) factors related function. Design: Six domains were studied 3,167 the baseline Study Women's Health Across Nation (SWAN). Participants 42 52 years old, pre-or perimenopausal, not using hormones. The...
Abstract Background and Aims To explore the inhibition mechanism of Saccharomyces boulardii ( S. ) on ulcerative colitis (UC) carcinogenesis. Methods C57BL/6 mice were treated with azoxymethane dextran sulfate sodium (AOM/DSS) to develop a UC carcinogenesis model. The treatment group was lavaged (5 × 10 7 CFU/d) for 12 weeks. sacrificed tumor load in compared that control group. levels TNF-α IL-6 colon tissue measured by enzyme-linked immunosorbent assays. influence regulation also...
Many fungal pathogens invade plants by means of specialized infection structures called appressoria. In the rice (Oryza sativa) blast fungus Magnaporthe grisea, pathogenicity mitogen-activated protein (MAP) kinase1 (PMK1) kinase is essential for appressorium formation and invasive growth. this study, we functionally characterized MST7 MST11 genes M. grisea that are homologous with yeast MAP STE7 STE11. Similar to pmk1 mutant, mst7 mst11 deletion mutants were nonpathogenic failed form When a...
OBJECTIVE Older adults with diabetes and dementia are at increased risk for hypoglycemia other adverse events associated tight glycemic control unlikely to experience long-term benefits. We examined factors in this population use of medications a high the subset control. RESEARCH DESIGN AND METHODS This retrospective cohort study national Veterans Affairs (VA) administrative/clinical data Medicare claims fiscal years (FYs) 2008–2009 included 15,880 veterans aged ≥65 type 2 prescribed...
To investigate the effects of VSL#3 on tumor formation, and fecal intestinal mucosal microbiota in azoxymethane/dextran sulfate sodium (AOM/DSS) induced mice model.C57BL/6 were administered AOM/DSS to develop ulcerative colitis (UC) carcinogenesis model. Mice treated with 5-ASA (75 mg/kg/d), (1.5 × 109 CFU/d), or combined by gavage from day AOM injection for three months (five days/week). The load was compared each group, necrosis factor (TNF-α) interleukin (IL)-6 levels evaluated colon...
Abstract Rice blast fungus (Magnaporthe grisea) forms a highly specialized infection structure for plant penetration, the appressorium, formation and growth of which are regulated by Mst11-Mst7-Pmk1 mitogen-activated protein kinase cascade. We characterized MST50 gene that directly interacts with both MST11 MST7. Similar to mst11 mutant, mst50 mutant was defective in appressorium formation, sensitive osmotic stresses, nonpathogenic. Expressing dominant active MST7 allele complemented its...
In Brief Objective: During the menopausal transition, total testosterone (T) remains unchanged, whereas estrogen decreases markedly, creating a state of relative androgen excess. We hypothesized that change in T-to-estradiol (T/E2) ratio during transition would be associated with incident metabolic syndrome. Methods: The association between syndrome and E2, T, sex hormone-binding globulin, free index, baseline T/E2 ratio, this over time was evaluated multiethnic cohort 1,862 premenopausal...
The effect of change in reproductive hormones and menopause on incident obesity (body mass index ≥30 kg/m2) severe ≥35 was evaluated over 9 years 3,260 US women recruited the multiethnic Study Women's Health Across Nation 1996–1997. After years, cumulative incidences reached 21.8% 12.3%, respectively. In multivariate analysis, hormone changes, chronic health conditions, lower physical activity, race/ethnicity, age were significantly associated with and/or obesity. odds increased surgical...
Magnaporthe oryzae starts its infection by the attachment of pyriform conidia on rice tissues, and severity disease epidemic is proportional to quantity produced in blast lesions. However, mechanism conidial production not well understood. Homeodomain proteins play critical roles regulating various growth developmental processes fungi other eukaryotes. Through targeted gene replacement, we find that deletion HTF1, one seven homeobox genes fungal genome, does affect mycelial but causes total...
Given the paucity of information on dose intensity, objective this study is to describe use adjuvant chemotherapy for stage III colon cancer, focusing relative intensity (RDI), overall survival (OS) and disease-free (DFS). Retrospective cohort 367 patients diagnosed with cancer in 2003–2008 treated at 19 VA medical centers. Kaplan-Meier curves summarize 5-year OS 3-year DFS by regimen RDI, multivariable Cox proportional hazards regression was used model these associations....
Plant genera with both diploid and polyploid species are a common evolutionary occurrence. Polyploids, especially allopolyploids such as cotton wheat, great model system for heterosis research. Here, we have integrated genome sequences transcriptome data of Gossypium to construct co-expression networks identified functional modules from different species, including 1155 1884 in G. arboreum hirsutum, respectively. We overlayed the gene expression results onto network. further provided network...
Pain, erectile dysfunction (ED), and depression are common yet frequently untreated in chronic hemodialysis patients. This study compared two management strategies for these symptoms this patient population.Pain, ED, were assessed monthly during an observation usual care phase. Patients then randomized to 12-month participation either a feedback arm which monthly, renal providers informed of patients' symptoms, treatment was left at their discretion; or nurse trained nurses used evaluate...
Background Imbalance of intestinal microbiota was closely related to colitis. Under these circumstances, regulation enteric flora may be beneficial the repair inflammation. We aimed investigate effects probiotics (Bifidobacterium and Lactobacillus), prebiotics their combination on inflammation, microflora in mice acute Methods C57BL/6J were divided into six groups randomly (blank control group, model synbiotics lactitol group + group). Each given 2.5% dextran sulfate sodium drinking water...
Cold stress restricts peanut (Arachis hypogaea L.) growth, development, and yield. However, the specific mechanism of cold tolerance in remains unknown. Here, comparative physiological, transcriptomic, lipidomic analyses tolerant variety NH5 sensitive FH18 at different time points were conducted to fill this gap. Transcriptomic analysis revealed lipid metabolism including membrane fatty acid may be a significant contributor tolerance, 59 cold-tolerant genes involved identified. Lipidomic...
Trehalose is vital for plant metabolism, growth, and stress resilience, relying on
Summary In Magnaporthe grisea , the MST11‐MST7‐PMK1 MAP kinase (MAPK) cascade is essential for appressorium formation and plant infection. Although expressing a dominant active MST7 allele results in Pmk1 activation absence of Mst11 improper regulation formation, direct interaction between Mst7 not observed yeast two‐hybrid assays. Thus, it clear how transmits upstream signals to Pmk1. Like its homologues from other ascomycetes, contains putative MAPK‐docking site (12–20) at N‐terminus....
The formation and maturation of membrane carriers that transport cargo from the ER to Golgi complex involves sequential action coat protein complexes COPII COPI. Recruitment COPI nascent requires activation ADP-ribosylation factors by a BrefeldinA-sensitive guanine nucleotide exchange factor. Using new antisera GFP-tagged protein, we demonstrate factor GBF1 localized both membranes peripheral puncta, near but separate exit sites. Live cell imaging revealed GFP-GBF1 associates dynamically...
Objectives To examine the association between CNS medication burden and serious falls in those with a recent fall history. Design Nested‐case control study; cases matched to four controls by age, gender, date. Setting US nursing homes. Participants 5,556 residents age ≥65 history admitted home 1/1‐9/30/2010 followed until discharge, death, or December 31, 2010. Measurements Outcome was as per Medicare Part A B ICD / CPT codes. burden, from D data, calculated dividing daily dose of each agent...
To estimate the prevalence and consequences of receiving prescription opioids from both Department Veterans Affairs (VA) Medicare Part D.Among US veterans enrolled in VA D filling 1 or more opioid prescriptions 2012 (n = 539 473), we calculated 3 safety measures using morphine milligram equivalents (MME): (1) proportion greater than 100 MME for days, (2) mean days MME, (3) 120 90 consecutive days. We compared these by source.Overall, 135 643 (25.1%) received only, 332 630 (61.7%) 71 200...