A5058137203- Cancer-related molecular mechanisms research
- Neonatal and Maternal Infections
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related gene regulation
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Extracellular vesicles in disease
- Electric Vehicles and Infrastructure
- Lymphatic System and Diseases
- Vascular Malformations and Hemangiomas
- Drug-Induced Hepatotoxicity and Protection
- Probiotics and Fermented Foods
- Complement system in diseases
- Electric and Hybrid Vehicle Technologies
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Sepsis Diagnosis and Treatment
- Inflammation biomarkers and pathways
- IL-33, ST2, and ILC Pathways
- Cancer, Lipids, and Metabolism
- Lymphatic Disorders and Treatments
- Mast cells and histamine
- Berberine and alkaloids research
- Cell Adhesion Molecules Research
Hebei Agricultural University
2024
First Affiliated Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Liaocheng University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2019
Peking Union Medical College Hospital
2015
Molecular Oncology (United States)
2015
State Key Laboratory of Molecular Oncology
2015
Introduction Heat-killed probiotics, as a type of inactivated beneficial microorganisms, possess an extended shelf life and broader adaptability compared to their live counterparts. This study aimed investigate the impact heat-killed Lactobacillus acidophilus ( L. , LA) - deactivated probiotic on growth performance, digestibility, antioxidant status, immunity cecal microbiota rabbits. Methods Two hundred weaned Hyla rabbits were randomly allocated into five equal groups (CON, L 200 400 600...
Mast cells (MCs) have been reported to be one of the important immunoregulatory in promoting development colitis-related colon cancer (CRC). It is not clear which MC subtypes play critical roles CRC progression from colitis because mucosal mast (MMCs) are distinct connective tissue (CTMCs) maintaining intestinal barrier function under homeostatic and inflammatory conditions. In current study, we found that MMC numbers gene expressions MMC-specific proteases increased significantly an induced...
Hippo signaling plays critical roles in intestinal regeneration. However, the mechanisms which regulate its activity vivo are largely unknown. We hypothesize that protease-activated receptor 2 (PAR2) signaling, could be activated by trypsin, might affect YAP setting of tissue damage and It is found knockout PAR2 severely aggravates mucosal induced dextran sodium sulfate (DSS) mouse, correlated with notable repression protein colonic epithelial cells. Although cytokine expression reduced,...
Silibinin possesses the efficacy of anticancer and anti-inflammation. We aimed to test whether silibinin could prevent colitis-associated carcinogenesis in mouse model. Azoxymethane (AOM) dextran sulfate sodium (DSS) were used induce tumorigenesis C57BL mice. Six-to-eight-week-old male mice gavaged with 350 or 750 mg/kg for 10 weeks right after DSS administration. The then sacrificed, colon tissues measured tumor multiplicity size. Molecular changes about proliferation, apoptosis...
Lef1/Tcfs family, which includes Lef1, Tcf1, Tcf3, and Tcf4, is required for the transcriptional activation induced by β‐catenin. However, whether all members play same role in colon carcinogenesis not clear. We found that Lef1 but Tcf3 were upregulated at both mRNA protein level with formation of tumor AOM‐DSS mouse model. The profiles seen human specimens evolvement from adenoma to adenocarcinoma. Additionally, Tcf1 correlated a subgroup Wnt target genes, including Lgr5, key gene...
The purpose of this study is to examine the expression levels lymphatic endothelial markers in colorectal cancer and explore correlation between lymph node status.Forty-seven paired fresh tumor tissues para-cancerous were collected from patients who received surgical treatment August 2015 March 2016 Cancer Hospital, Chinese Academy Medical Sciences. Real-time quantitative PCR (RTQ-PCR) was used check LYVE-1, VEGFR-3, Podoplanin, Prox-1 tissues.The positive rates 100, 93.6, 91.4%, but 87.2%...
The main problem in current energy management is the ability of practical application. To address problem, this paper proposes a reinforcement learning (RL)-based by combining Tubule Q-learning and Pontryagin’s Minimum Principle (PMP) algorithms for plug-in hybrid electric bus (PHEB). innovation distinguished from existing strategies that dynamic SOC design zone plan method proposed. It characterized two aspects: ① series fixed locations are defined city route linear reference trajectory...
Introduction Yeast peptides have garnered attention as valuable nutritional modifiers due to their potential health benefits. However, the precise mechanisms underlying effects remain elusive. This study aims explore of yeast peptides, when added diets, mitigate lipopolysaccharide (LPS)-induced intestinal damage and microbiota alterations in rabbits. Methods A total 160 35-day-old Hyla line rabbits (0.96 ± 0.06 kg) were randomly assigned 4 groups. These groups constituted a 2 × factorial...
Abstract Wnt/β-catenin pathway is activated in many cancers, especially colorectal carcinoma (CRC). LEF1/TCFs family, which includes LEF1, TCF7(TCF1), TCF7L1(TCF3) and TCF7L2(TCF4), are required for β-catenin-induced transcription of target genes widely involved the carcinogenesis. The aims our study were to investigate change members family chronic inflammation associated carcinogenesis possible roles Chronic inflammation-associated CRC was induced with AOM-DSS mouse model. Gene expression...