A5001497458- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Pelvic floor disorders treatments
- Neuroblastoma Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Lung Cancer Research Studies
- Urinary Bladder and Prostate Research
- Meningioma and schwannoma management
- Epigenetics and DNA Methylation
- MRI in cancer diagnosis
- Management of metastatic bone disease
- Urologic and reproductive health conditions
- Urinary Tract Infections Management
- Lung Cancer Treatments and Mutations
- Nanoplatforms for cancer theranostics
- Spinal Fractures and Fixation Techniques
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Antifungal resistance and susceptibility
Michigan Medicine
2016-2025
University of Michigan–Ann Arbor
2016-2025
Massachusetts General Hospital
2015-2024
Harvard University
2015-2024
Michigan United
2022-2024
MaineGeneral Medical Center
2024
University of Virginia
2017-2023
Michigan Center for Translational Pathology
2022
Rutgers, The State University of New Jersey
2020
Ann Arbor VA Medical Center
2018
We have used gene targeting to generate mice with a homozygous deficiency in trp2, cation channel expressed the vomeronasal organ (VNO). Trp2 mutant animals reveal striking reduction electrophysiological response pheromones VNO, suggesting that trp2 plays central role mediating pheromone response. These mutants therefore afford opportunity examine of VNO generation innate sexual and social behaviors mice. males nursing females are docile fail initiate aggressive attacks on intruder males....
<h3>Background</h3> Critically ill patients are medically complex and may benefit from a multidisciplinary approach to care. <h3>Methods</h3> We conducted population-based retrospective cohort study of medical admitted Pennsylvania acute care hospitals (N = 169) July 1, 2004, June 30, 2006, linking statewide hospital organizational survey discharge data. Multivariate logistic regression was used determine the independent relationship between daily rounds 30-day mortality. <h3>Results</h3> A...
PURPOSE To assess whether reirradiation (re-RT) and concurrent bevacizumab (BEV) improve overall survival (OS) and/or progression-free (PFS), compared with BEV alone in recurrent glioblastoma (GBM). The primary objective was OS, secondary objectives included PFS, response rate, treatment adverse events (AEs) including delayed CNS toxicities. METHODS NRG Oncology/RTOG1205 is a prospective, phase II, randomized trial of re-RT versus alone. Stratification factors age, resection, Karnofsky...
Abstract Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this finding remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/cerebrospinal fluid (CSF) correlate samples from patients treated two completed multisite studies. following initial radiation prior to recurrence a median overall survival of 21.7 months, whereas those after had 9.3...
The Centers for Medicare and Medicaid Services (CMS) has implemented the CMS-Hierarchical Condition Category (CMS-HCC) model to risk adjust capitation payments. This study intends assess performance of CMS-HCC adjustment method compare it Charlson Elixhauser comorbidity measures in predicting in-hospital six-month mortality beneficiaries. used 2005-2006 Chronic Data Warehouse (CCW) 5% files. primary sample included all community-dwelling fee-for-service beneficiaries with a hospital...
Radiation with concurrent and adjuvant (6 cycles) temozolomide (TMZ) is the established standard of postsurgical care for newly diagnosed glioblastoma (GBM). This regimen has been adopted variations, including extending TMZ beyond 6 cycles. The optimal duration maintenance therapy remains controversial. We performed pooled analysis individual patient data from 4 randomized trials GBM. All patients who were progression free 28 days after cycle included. decision to continue was per local...
The management of patients with glioma usually requires multimodality treatment including surgery, radiotherapy, and systemic therapy. Accurate neuroimaging plays a central role for radiotherapy planning follow-up after completion. In order to maximize the radiation dose tumor minimize toxic effects on surrounding brain parenchyma, reliable identification extent target volume delineation is crucial. use positron emission tomography (PET) monitoring in gliomas has gained considerable interest...
Background. Local progression of advanced gastric cancer often manifests as bleeding, dysphagia/obstruction, or pain. We evaluated the magnitude and durability palliation with radiotherapy (RT). Material methods. From 1996 to 2004, 37 patients were treated palliative RT (median dose 35Gy in 14 fractions). Nearly two-thirds all received concurrent chemoradiation therapy (CRT). Index pre-treatment symptoms pain 54%, 43%, 19% patients, respectively. Results. The rates control for 70% (14/20),...
Background. Coccidioidomycosis is a fungal infection of the desert southwestern United States. It may be self-limited or require antifungal therapy. Currently used triazoles (eg, fluconazole and itraconazole) have largely supplanted amphotericin B, which fraught with adverse effects. Limited case reports small open-label trials show that voriconazole posaconazole benefit patients coccidioidomycosis refractory to first-line agents.
Abstract Community-acquired pneumonia (CAP) often results in severe illness and death. In large, geographically defined areas where Coccidioides spp. are endemic, coccidioidomycosis is a recognized cause of CAP, but its frequency has not been studied extensively. To determine the patients with coccidioidomycosis, we conducted prospective evaluation 59 CAP Phoenix, Arizona, area. Of 35 for whom paired coccidioidal serologic testing was performed, 6 (17%) had evidence acute coccidioidomycosis....
Many studies in patients with brain tumors evaluating innovative PET tracers have been published recent years, and the initial results are promising. Here, Response Assessment Neuro-Oncology (RANO) working group provides an overview of literature on novel investigational for tumor patients. Furthermore, newer indications more established evaluation glucose metabolism, amino acid transport, hypoxia, cell proliferation, others also discussed. Based preliminary findings, these should be further...