A5048404962- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Nanoplatforms for cancer theranostics
- Functional Brain Connectivity Studies
- Neuroblastoma Research and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Amino Acid Enzymes and Metabolism
- Advanced X-ray and CT Imaging
- Acute Ischemic Stroke Management
- Cancer Immunotherapy and Biomarkers
- Neuroscience and Neuropharmacology Research
- Brain Tumor Detection and Classification
- Lung Cancer Research Studies
- Machine Learning in Materials Science
- Pituitary Gland Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Management of metastatic bone disease
Forschungszentrum Jülich
2016-2025
University of Cologne
2016-2025
University Hospital Cologne
2016-2025
Sapienza University of Rome
2016-2024
Istituto Neurologico Mediterraneo
2016-2024
Integrated Oncology (United States)
2016-2024
Düsseldorf University Hospital
2016-2024
Heinrich Heine University Düsseldorf
2013-2024
Klinik und Poliklinik für Neurologie
2005-2024
University of Bonn
2016-2024
Impairment of insulin signaling in the brain has been linked to neurodegenerative diseases. To test hypothesis that neuronal resistance contributes defects function, we have performed a detailed analysis brain/neuron-specific receptor knockout (NIRKO) mice. We find NIRKO mice exhibit complete loss insulin-mediated activation phosphatidylinositol 3-kinase and inhibition apoptosis. In intact animals, this results markedly reduced phosphorylation Akt GSK3β, leading substantially increased...
These joint practice guidelines, or procedure standards, were developed collaboratively by the European Association of Nuclear Medicine (EANM), Society and Molecular Imaging (SNMMI), Neurooncology (EANO), working group for Response Assessment in with PET (PET-RANO). Brain imaging is being increasingly used to supplement MRI clinical management glioma. The aim these standards/guidelines assist nuclear medicine practitioners recommending, performing, interpreting reporting results brain...
Optimal treatment and precise classification for anaplastic glioma are needed. The objective long-term follow-up of NOA-04 is to optimize the sequence patients with gliomas. Patients were randomized 2:1:1 receive standard radiotherapy (RT) (arm A), procarbazine, lomustine vincristine (PCV) B1), or temozolomide (TMZ) B2). Primary endpoint was time-to-treatment-failure (TTF), defined as progression after 2 lines therapy any time before if no further administered. Exploratory analyses examined...
We evaluated the diagnostic value of static and dynamic O-(2-[(18)F]fluoroethyl)-L-tyrosine ((18)F-FET) PET parameters in patients with progressive or recurrent glioma.We retrospectively analyzed 132 (18)F-FET conventional MRI scans 124 glioma (primary World Health Organization grade II, n = 55; III, 19; IV, 50; mean age, 52 ± 14 y). Patients had been referred for assessment clinical signs and/or findings suggestive tumor progression recurrence based on Response Assessment Neuro-Oncology...
To provide practice guideline/procedure standards for diagnostics and therapy (theranostics) of meningiomas using radiolabeled somatostatin receptor (SSTR) ligands. This joint standard was collaboratively developed by the European Association Nuclear Medicine (EANM), Society Molecular Imaging (SNMMI), Neurooncology (EANO), PET task force Response Assessment in Working Group (PET/RANO). Positron emission tomography (PET) ligands can detect meningioma tissue with high sensitivity specificity...
Treatment of the tumor and dural margin with surgery sometimes radiation are cornerstones therapy for meningioma. Molecular classifications have provided insights into biology disease; however, response to treatment remains heterogeneous. In this study, we used retrospective data on 2,824 meningiomas, including molecular 1,686 tumors 100 prospective from RTOG-0539 phase 2 trial define biomarkers response. Using propensity score matching, found that gross resection was associated longer...
Locus ceruleus (LC) degeneration and loss of cortical noradrenergic innervation occur early in Alzheimer’s disease (AD). Although this has been known for several decades, the contribution LC to AD pathogenesis remains unclear. We induced with N -(2-chloroethyl)- -ethyl-bromo-benzylamine (dsp4) amyloid precursor protein 23 (APP23) transgenic mice a low load. Then 6 months later projection areas showed robust elevation glial inflammation along augmented plaque deposits. Moreover,...
The assessment of treatment response in glioblastoma is difficult with MRI because reactive blood–brain barrier alterations contrast enhancement can mimic tumor progression. In this study, we investigated the predictive value PET using <i>O</i>-(2-<sup>18</sup>F-fluoroethyl)-l-tyrosine (<sup>18</sup>F-FET PET) during treatment. <b>Methods:</b> a prospective 25 patients were by and <sup>18</sup>F-FET after surgery (MRI-/FET-1), early (7–10 d) completion radiochemotherapy temozolomide (RCX)...
The aim of this study was to investigate the potential <i>O</i>-(2-<sup>18</sup>F-fluoroethyl)-l-tyrosine (<sup>18</sup>F-FET) PET for differentiating local recurrent brain metastasis from radiation necrosis after therapy because use contrast-enhanced MRI issue is often difficult. <b>Methods:</b> Thirty-one patients (mean age ± SD, 53 11 y) with single or multiple contrast-enhancing lesions (<i>n</i> = 40) on metastases were investigated dynamic <sup>18</sup>F-FET PET. Maximum and mean...
The aim of this study was to assess the clinical value <i>O</i>-(2-<sup>18</sup>F-fluoroethyl)-l-tyrosine (<sup>18</sup>F-FET) PET in initial diagnosis cerebral lesions suggestive glioma. <b>Methods:</b> In a retrospective study, we analyzed clinical, radiologic, and neuropathologic data 174 patients (77 women 97 men; mean age, 45 ± 15 y) who had been referred for neurosurgical assessment unclear brain undergone <sup>18</sup>F-FET PET. Initial histology (<i>n</i> = 168, confirmed after...