A5062344635- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Organ Transplantation Techniques and Outcomes
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Liver Disease and Transplantation
- Radiation Dose and Imaging
- Pharmacological Receptor Mechanisms and Effects
- Renal Transplantation Outcomes and Treatments
- Cardiac Imaging and Diagnostics
- Lanthanide and Transition Metal Complexes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroscience and Neuropharmacology Research
- Atomic and Subatomic Physics Research
- Clinical Nutrition and Gastroenterology
- Liver Disease Diagnosis and Treatment
- Neurological disorders and treatments
- Computational Drug Discovery Methods
- Radiation Therapy and Dosimetry
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
University Hospital Leipzig
2015-2025
Leipzig University
2013-2025
Klinik und Poliklinik für Nuklearmedizin
1997-2025
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2023
München Klinik
2017
European Association of Nuclear Medicine
2013-2015
IFB Adiposity Diseases
2014
Kiel University
2014
University of Lübeck
2013
University Hospital Schleswig-Holstein
2013
These joint practice guidelines, or procedure standards, were developed collaboratively by the European Association of Nuclear Medicine (EANM), Society and Molecular Imaging (SNMMI), Neurooncology (EANO), working group for Response Assessment in with PET (PET-RANO). Brain imaging is being increasingly used to supplement MRI clinical management glioma. The aim these standards/guidelines assist nuclear medicine practitioners recommending, performing, interpreting reporting results brain...
Use of PET/MR in children has not previously been reported, to the best our knowledge. Children with systemic malignancies may benefit from reduced radiation exposure offered by PET/MR. We report initial experience hybrid imaging and current established sequence protocol after 21 studies 15 multifocal malignant diseases. The effective dose a scan was only about 20% that equivalent PET/CT examination. Simultaneous acquisition PET MR data combines advantages two separate modalities....
In early Alzheimer's dementia, there is a need for PET biomarkers of disease progression with close associations to cognitive dysfunction that may aid predict further decline and neurodegeneration. Amyloid are not suitable purpose. The α4β2 nicotinic acetylcholine receptors (α4β2-nAChRs) widely abundant in the human brain. As neuromodulators they play an important role functions such as attention, learning memory. Post-mortem studies reported lower expression α4β2-nAChRs more advanced...
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific professional organization founded in 1954 to promote the science, technology, practical application nuclear medicine. European Association (EANM) a non-profit medical association that facilitates communication worldwide between individuals pursuing clinical research excellence EANM was 1985. merged International for Magnetic Resonance (ISMRM) international, nonprofit, whose purpose communication,...
Abstract This paper summarises the proceedings and discussions at third annual workshop held in Tübingen, Germany, dedicated to advancement of technical, scientific clinical applications combined PET/MRI systems humans. Two days basic technical instructions with “hands-on” tutorials were followed by 3 invited presentations from active researchers this associated fields augmented round-table dialogue boards specific themes. These included use paediatric oncology adult neurology, cardiology,...
Purpose: Integrated positron emission tomography/magnetic resonance (PET/MR) systems derive the PET attenuation correction (AC) from dedicated MR sequences. While MR‐AC performs reasonably well in clinical patient imaging, it may fail for phantom‐based quality control (QC). The authors assess applicability of different protocols QC multicenter PET/MR imaging. Methods: National Electrical Manufacturers Association NU 2 2007 image phantom was imaged on three combined systems: a Philips...
Prospective studies on magnetic resonance imaging (MRI)-guided systemic thrombolysis 44.5 hours after stroke onset did not reach their primary end points. It was discussed and observed in post hoc data re-assessment that this partly because of limited MRI accuracy to measure critical hypoperfusion. We report the first cases simultaneous [ 15 O]H 2 O-positron emission tomography (PET)/MRI patients an ovine model. Discrepancies between simultaneously obtained PET readouts were might explain...
The 6th annual meeting to address key issues in positron emission tomography (PET)/magnetic resonance imaging (MRI) was held again Tübingen, Germany, from March 27 29, 2017. Over three days of invited plenary lectures, round table discussions and dialogue board deliberations, participants critically assessed the current state PET/MRI, both clinically as a research tool, attempted chart future directions. addressed use PET/MRI workflows oncology, neurosciences, infection, inflammation chronic...
Abstract Purpose Pridopidine is an investigational drug for Huntington disease (HD). was originally thought to act as a dopamine stabilizer. However, pridopidine shows highest affinity the sigma-1 receptor (S1R) and enhances neuroprotection via S1R in preclinical studies. Using [ 18 F] fluspidine fallypride PET, purpose of this study assess vivo target engagement/receptor occupancy D2/D3 (D2/D3R) at clinical relevant doses healthy volunteers (HVs) proof-of-concept small number patients with...
Ziel/Aim: Patienten dürfen nach Radionuklidtherapien (RNT) erst dann entlassen werden, wenn für Angehörige und Dritte (AuD) eine effektive Dosis von nicht mehr als 1 mSv pro Kalenderjahr (KJ) auftreten kann. Bei 177Lu-RNT erfolgen zumeist mehrere Applikationen KJ. Dabei kann die Abschätzung der Exposition mit konservativen Annahmen (physikalische Halbwertszeit (HWZ)) zur Vermutung führen, zulässigen im KJ AuD wäre überschritten, obwohl dies bei realistischeren Fall ist. Ziel vorgestellten...
The enantiomers of [(18)F]fluspidine, recently developed for imaging σ₁ receptors, possess distinct pharmacokinetics facilitating their use in different clinical settings. To support translational potential, we estimated the human radiation dose (S)-(-)-[(18)F]fluspidine and (R)-(+)-[(18)F]fluspidine from ex vivo biodistribution PET/MRI data mice after extrapolation to scale. In addition, validated preclinical results by performing a first-in-human PET/CT study using...