A5108373812- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Coronary Interventions and Diagnostics
- Radiation Dose and Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound and Hyperthermia Applications
- Atomic and Subatomic Physics Research
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Bone and Joint Diseases
- Lanthanide and Transition Metal Complexes
- Advanced Neuroimaging Techniques and Applications
- Vascular Procedures and Complications
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Medical Imaging and Pathology Studies
- Cardiovascular Disease and Adiposity
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Renal and Vascular Pathologies
- Lung Cancer Diagnosis and Treatment
Göteborgs Stads
2021
Landesamt für Landwirtschaft, Umwelt und ländliche Räume
2021
Copenhagen Municipal Hospital
2021
Capital Region of Denmark
2021
Region Zealand
2021
University Children's Hospital Tübingen
2004-2020
University of Tübingen
2007-2017
Universitätsklinikum Tübingen
2008-2017
Siemens (Germany)
2007-2013
Siemens Healthcare (Germany)
2013
Drug-eluting stents reduce restenosis in coronary arteries, but clinical trials have failed to prove their efficacy peripheral arteries. We investigated the use of paclitaxel-coated angioplasty balloons and paclitaxel dissolved angiographic contrast medium during leg.In a small, multicenter trial, we randomly assigned 154 patients with stenosis or occlusion femoropopliteal artery treatment standard balloon catheters coated paclitaxel, uncoated medium, without (control). The primary end point...
Insulin resistance plays an important role in the pathogenesis of type 2 diabetes; however, multiple mechanisms causing insulin are not yet fully understood. The aim this study was to explore possible contribution intramyocellular lipid content skeletal muscle resistance. We compared insulin-resistant and insulin-sensitive subjects. To meet stringent matching criteria for other known confounders resistance, these individuals were selected from extensively metabolically characterized group...
The purpose of this study was to apply a magnetic resonance (MR) imaging-compatible positron emission tomographic (PET) detector technology for simultaneous MR/PET imaging the human brain and skull base. PET ring consists lutetium oxyorthosilicate (LSO) scintillation crystals in combination with avalanche photodiodes (APDs) mounted clinical 3-T MR imager use birdcage transmit/receive head coil. Following phantom studies, two patients were simultaneously examined by using fluorine 18...
Brown adipose tissue (BAT) regulates energy homeostasis and fat mass in mammals newborns and, most likely, adult humans. Because BAT activity decline with age humans, the impact of on adiposity may decrease aging. In present study we addressed this hypothesis further investigated effect sex differences mass.Data from 260 subjects (98 162 date-matched control subjects) who underwent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) under...
We sought to determine the relaxivity and accurate relaxation rates of Gd-DTPA, Gd-BT-DO3A, Gd-BOPTA at 0.2, 1.5, 3 T in human blood plasma.Contrast media concentrations between 0.01 16 mM plasma were used for measurements. The R1 R2 r1 r2 relaxivities determined.Gd-BOPTA produced highest all field strengths. values 107-131% 91-244% higher than respectively, 72-98% 82-166% Gd-BT-DO3A. Higher strengths resulted lower R1, R2, contrast agents tested Gd-DTPA A linear dependence on concentration...
Estimates are presented for the sputtering yield as well specturm of sputtered atoms metals bombarded by heavy atomic or molecular ions, under assumption evaporation from an elastic-collision spike high initial temperature. The calculational is based on a cylindrical and thermal diffusivity proportional to square root Good qualitative agreement obtained between calculated measured sputter yields antimony incident silver.
Abstract The purpose of this analysis is to explore the potential diagnostic gain provided by viscoelastic shear properties breast lesions for improvement specificity contrast enhanced dynamic MR mammography (MRM). assessment done via elastography (MRE) and it demonstrated that complex modulus in vivo tissue follows within frequency range clinical MRE a power law behavior. Taking benefit behavior, data are interpreted framework exact model wave propagation satisfying causality principle....
Abstract Background The pathogenesis of type 2 diabetes is characterized by insulin resistance and β‐cell dysfunction. Pancreatic fat load may add to the development aim was thoroughly quantify content pancreas sections (caput, corpus, cauda) compare impact pancreatic, intrahepatic, visceral on secretion in humans. Methods Fifty‐one subjects were subjected an oral glucose tolerance test (OGTT) with glucose, insulin, C‐peptide measurements [28 displayed normal tolerance, 23 impaired fasting...
Purpose To compare positron emission tomography (PET)/magnetic resonance (MR) imaging and PET/computed (CT) for lesion detection interpretation, quantification of fluorine 18 (18F) fluorodeoxyglucose (FDG) uptake, accuracy MR-based PET attenuation correction in pediatric patients with solid tumors. Materials Methods This prospective study had local ethics committee German Federal Institute Drugs Medical Devices approval. Written informed consent was obtained from all legal guardians. Twenty...
An increased intramyocellular lipid (IMCL) content, as quantified by 1H-magnetic resonance spectroscopy (1H-MRS), is associated with reduced insulin sensitivity. At present, it unclear which factors determine IMCL formation and how rapidly accumulation can be induced. We therefore studied the impact of hyperinsulinemia elevated circulating nonesterified fatty acid (NEFA) levels on further evaluated influence a high-fat diet storage. In infusion protocol, 12 healthy male subjects underwent...
PURPOSE: To evaluate the influence of menstrual cycle and age on parenchymal contrast medium enhancement in magnetic resonance (MR) imaging breast. MATERIALS AND METHODS: Dynamic gadolinium-enhanced fast low-angle shot, three-dimensional breast MR was performed with high temporal spatial resolution (eight measurements 10 minutes). Menstrual evaluations age-influence studies were 44 patients aged 27-55 years a regular (mean age, 41.5 years) 103 15-79 49.3 years), respectively. A region...
Abstract Purpose To assess standardized whole body adipose tissue topography in a cohort of subjects at an increased risk for type 2 diabetes and to compare fat distribution subgroups regarding anthropometric (age, mass index [BMI]) metabolic parameters (insulin sensitivity). Materials Methods A total 80 volunteers (40 females, 40 males) underwent T1‐weighted MR imaging the entire body. Standardized (AT) profiles were calculated considering different structure participants. The measured data...
Simultaneous PET and MRI using new hybrid PET/MRI systems promises optimal spatial temporal coregistration of structural, functional, molecular image data. In a pilot study 10 patients with intracranial masses, the feasibility tumor assessment system comprising lutetium oxyorthosilicate scintillators coupled to avalanche photodiodes was evaluated, quantification accuracy compared conventional PET/CT datasets. <b>Methods:</b> All measurements were performed scanner consisting 3-T in...
To prospectively evaluate the effect of heart rate, rate variability, and calcification on dual-source computed tomography (CT) image quality to assess diagnostic accuracy CT for coronary artery stenosis, by using invasive angiography as reference standard.This study had local Ethics Committee approval; all patients gave informed consent. Patients who underwent bypass surgery were excluded; with stent-grafts included. One hundred (20 women, 80 men; mean age, 62 years +/- 10 [standard...
The existence of metabolically relevant intramyocellular lipids (IMCL) as assessed by the noninvasive 1H-magnetic resonance spectroscopy (MRS) has been established. In present studies, we analyzed relationships between IMCL in two muscle types [the predominantly nonoxidative tibialis (tib) and oxidative soleus (sol)] anthropometric data, aerobic capacity (VO2max, bicycle ergometry, n = 77) insulin sensitivity (hyperinsulinemic euglycemic clamp, 105) using regression analysis. univariate...
Magnetic resonance (MR) imaging was performed on 40 patients with intracranial tumors, before and after intravenous administration of gadolinium-DTPA (Gd-DTPA). Precontrast studies included a comprehensive protocol spin-echo sequences. Tumors were visualized precontrast images either directly or indirectly by anatomic distortion caused the mass. However, differentiation tumor from adjacent tissues possible in only 17 cases. Delineation best precontrast, T2-weighted images. After Gd-DTPA (0.1...
PURPOSE: To compare in vivo coagulation necrosis obtained with four radiofrequency (RF) ablation devices, to determine shape and reproducibility of induced by means three-dimensional measurements the zone, achieve representations coagulated areas spaces. MATERIALS AND METHODS: Four commercially available RF devices (perfusion, internally cooled cluster, nine- 12-tine expandable electrodes) that represent most widely used systems on market were tested. Sixteen procedures performed porcine...
To investigate how the technique of retrospective gating can be used to optimize reconstruction multi-detector row computed tomographic (CT) images for each three major coronary arteries during cardiac cycle.Multi-detector CT angiograms obtained in 50 patients were reconstructed at 20%-80% cycle increments 10%. Two blinded independent reviewers assessed image quality, terms artifacts and visibility, with three-dimensional postprocessing segments 1-3 (right artery), 5-8 (left main left...