A5081741444- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- MRI in cancer diagnosis
- Vascular Malformations Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Moyamoya disease diagnosis and treatment
- Venous Thromboembolism Diagnosis and Management
- Vascular Malformations and Hemangiomas
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Health and Disease Prevention
- Radiation Dose and Imaging
- Brain Metastases and Treatment
- Stroke Rehabilitation and Recovery
- Neurological Complications and Syndromes
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Lanthanide and Transition Metal Complexes
- Cerebral Venous Sinus Thrombosis
University of Tübingen
2016-2025
University Children's Hospital Tübingen
2013-2025
Klinikum Osnabrück
2024
Universitätsklinikum Tübingen
2007-2023
Bernstein Center for Computational Neuroscience Tübingen
2016-2023
LMU Klinikum
2021-2022
Ludwig-Maximilians-Universität München
2021-2022
University Hospital Bonn
2022
Agaplesion Markus Hospital
2021
Society of Interventional Radiology
2009-2019
Purpose The standard of care for anaplastic gliomas is surgery followed by radiotherapy. NOA-04 phase III trial compared efficacy and safety radiotherapy chemotherapy at progression with the reverse sequence in patients newly diagnosed gliomas. Patients Methods (N = 318) were randomly assigned 2:1:1 (A:B1:B2) to receive conventional (arm A); procarbazine, lomustine (CCNU), vincristine (PCV; arm B1); or temozolomide B2) diagnosis. At occurrence unacceptable toxicity disease progression, A...
Simultaneous PET and MRI using new hybrid PET/MRI systems promises optimal spatial temporal coregistration of structural, functional, molecular image data. In a pilot study 10 patients with intracranial masses, the feasibility tumor assessment system comprising lutetium oxyorthosilicate scintillators coupled to avalanche photodiodes was evaluated, quantification accuracy compared conventional PET/CT datasets. <b>Methods:</b> All measurements were performed scanner consisting 3-T in...
Background and Purpose— The introduction of flow diverters (FDs) has expanded the possibilities for reconstructive treatment difficult intracranial aneurysms. Concern remains as to long-term patency perforating arteries side branches covered during stent placement. Our purpose was evaluate performance early effect on after implantation Silk FD in basilar artery Methods— Twelve patients with an aneurysm that treated by were included our retrospective study. Both unruptured previously...
Cross-sectional studies using diffusion tensor imaging (DTI) suggest decline of the integrity intracortically projecting fiber tracts with aging and in neurodegenerative diseases, such as Alzheimer's disease (AD). Longitudinal on chang
<h3>BACKGROUND AND PURPOSE:</h3> IR has recently demonstrated its capacity to reduce noise and permit dose reduction in abdominal thoracic CT applications. The purpose of our study was assess the potential benefit head by comparing objective subjective image quality with standard FBP at various levels. <h3>MATERIALS METHODS:</h3> Ninety consecutive patients were randomly assigned undergo nonenhanced contrast-enhanced a (320 mAs; CTDI, 60.1) or 15% (275 51.8) 30% (225 42.3) reduction. All...
Endovascular therapy is the standard of care in treatment acute ischemic stroke due to large-vessel occlusion. Often, more than one retrieval attempt needed achieve reperfusion. We aimed quantify influence endovascular on clinical outcome depending number retrievals for successful reperfusion a large multi-center cohort. For this observational cohort study, 2611 patients from prospective German Stroke Registry included between June 2015 and April 2018 were analyzed. Patients who received...
PURPOSE Prospective data suggested a superiority of intraoperative MRI (iMRI) over 5-aminolevulinic acid (5-ALA) for achieving complete resections contrast enhancement in glioblastoma surgery. We investigated this hypothesis prospective clinical trial and correlated residual disease volumes with outcome newly diagnosed glioblastoma. METHODS This is controlled multicenter parallel-group two center-specific treatment arms (5-ALA iMRI) blinded evaluation. The primary end point was resection on...
Background/Objectives: The non-invasive identification of glioma subtypes is useful for initial diagnosis, treatment planning, and follow-up. aim this study was to evaluate the performance diffusion kurtosis imaging (DKI) dynamic contrast-enhanced (DCE)-MRI in differentiating adult-type diffuse gliomas. Methods: In a prospective multicenter study, standardized MRI analyzed 59 patients with glioma. DKI DCE-MRI parameter values were quantitatively evaluated ROIs contrast-enhancing/solid tumor...
Diffusion-weighted imaging (DWI) may be a useful tool to evaluate the efficacy of cerebral protection devices in preventing thromboembolic complications during carotid angioplasty and stenting (CAS). The goals this study were (1) compare frequency, number, size new DWI lesions after unprotected protected CAS; (2) determine clinical significance these lesions.DWI was performed immediately before within 48 hours or CAS. Clinical outcome measures stroke death 30 days.The proportion patients...
For clinical implementation, a chemical exchange saturation transfer (CEST) imaging sequence must be fast, with high signal-to-noise ratio (SNR), 3D coverage, and produce robust contrast. However, spectrally selective CEST contrast requires dense sampling of the Z-spectrum, which increases scan duration. This article proposes compromise: using snapshot gradient echo (GRE) readout optimized presaturation, sampling, postprocessing, highly resolved Z-spectroscopy at 3T is made possible coverage...
Background Patients aged ≥90 were excluded or under‐represented in past thrombectomy trials; thus, uncertainty remains whether treatment benefits can be expected regardless of age. This study investigates outcome and safety nonagenarians to improve decision making a real‐world setting. Methods Results All currently available data patients enrolled the GSR‐ET (German Stroke Registry–Endovascular Treatment) combined with smaller cohort from 3 tertiary stroke centers. Baseline characteristics,...
Endovascular therapy is the standard of care in treatment acute ischemic stroke due to large-vessel occlusion. A direct association between number device passes and occurrence symptomatic intracranial hemorrhage (SICH) has been suggested. This study represents an in-depth investigation hypothesis that >3 retrieval attempts associated with increased rate SICH a large multicenter patient cohort. Two thousand six hundred eleven patients from prospective German Stroke Registry were analyzed....
This study evaluates the benefit of endovascular treatment (EVT) for patients with extensive baseline stroke compared best medical treatment.This retrospective, multicenter compares EVT and computed tomography (CT)–based selection infarcts (Alberta Stroke Program Early CT Score ≤5) attributed to anterior circulation stroke. Patients were selected from German Registry 3 tertiary centers. Primary functional end points rates good (modified Rankin Scale score ≤3) very poor outcome ≥5) at 90...
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Recently, 3 randomized controlled trials provided high-level evidence that patients with large ischemic stroke achieved better functional outcomes after endovascular therapy than medical care alone. We aimed to investigate whether the clinical benefit of is associated number recanalization attempts in extensive baseline infarction.This retrospective multicenter study enrolled from German Stroke Registry who underwent for anterior circulation vessel occlusion between 2015 and 2021. Large was...