A5081601827- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Spinal Dysraphism and Malformations
- Spine and Intervertebral Disc Pathology
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Cerebral Venous Sinus Thrombosis
- Head and Neck Surgical Oncology
- Intensive Care Unit Cognitive Disorders
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Tuberous Sclerosis Complex Research
- Brain Metastases and Treatment
- Moyamoya disease diagnosis and treatment
- Surgical site infection prevention
- Photoreceptor and optogenetics research
- Fetal and Pediatric Neurological Disorders
- Cancer-related gene regulation
Universitätsmedizin Göttingen
2017-2024
Johanniter-Krankenhaus Bonn
2022-2024
University of Göttingen
2016-2023
CSL (Switzerland)
2021
Praxis
2020
Innsbruck Medical University
2020
Universität Innsbruck
2020
Unfallkrankenhaus Berlin
2013-2018
United States Nuclear Regulatory Commission
2018
University Hospital Schleswig-Holstein
2016-2017
<h3>BACKGROUND AND PURPOSE:</h3> Recent studies have suggested that wall enhancement of unruptured intracranial aneurysms in high-resolution MR imaging might serve as an biomarker for higher risk rupture. Histologic revealed a possible association among inflammatory processes, degeneration, and destabilization the aneurysm preceding Understanding histologic condition underlying could be important step toward assessing value this method stratification. We present our observations vessel...
PURPOSE Prospective data suggested a superiority of intraoperative MRI (iMRI) over 5-aminolevulinic acid (5-ALA) for achieving complete resections contrast enhancement in glioblastoma surgery. We investigated this hypothesis prospective clinical trial and correlated residual disease volumes with outcome newly diagnosed glioblastoma. METHODS This is controlled multicenter parallel-group two center-specific treatment arms (5-ALA iMRI) blinded evaluation. The primary end point was resection on...
Intracerebral vascular malformations including cavernous angiomas (CAs) and arteriovenous (AVMs) are an important cause of chronic pharmacoresistant epilepsies. Little is known about the pathogenetic basis epilepsy in patients with malformations. deposits iron-containing blood products have been generally regarded as responsible for strong epileptogenic potential CAs. Here, we analyzed whether blood-brain barrier (BBB) dysfunction subsequent astrocytic albumin uptake, recently described...
Tuberous sclerosis complex (TSC) is a common hereditary disorder caused by mutations in either the TSC1 or TSC2 genes, and characterized severe epilepsy, cerebral hamartomas mental retardation. We have used rats that are heterozygous for an autosomal-dominant germline mutation gene (TSC2+/- rats) to examine consequences of hippocampal synaptic plasticity. While basal transmission Schaffer collateral-CA1 synapse was not altered, paired-pulse plasticity significantly enhanced TSC2+/-...
Breast cancer has been associated with activation of the WNT signaling pathway, although no driver mutations in genes have found yet. Instead, a high expression alternative receptor ROR2 was observed, particular breast brain metastases. However, its respective ligand and downstream this context remained unknown. We modulated human cells characterized their gene protein by RNA-Seq, qRT-PCR, immunoblots reverse phase array (RPPA) combined network analyses to understand molecular basis cancer....
Hygiene measures were intensified when the COVID-19 pandemic began. Patient contacts limited to a minimum. Visitors either not allowed for certain period or rest of time. The hospital staff began wear masks and gloves continuously. Clinical examinations routine wound controls also performed under hygiene standards. These circumstances result in limitation direct physical interactions between nursing staff, physicians patients. We analyzed what extent intensification affects rate surgical...
Summary Purpose Precise outcome data about the surgical therapy of cerebral cavernous malformation (CCM)–associated epilepsy is scarce regarding different types, approach, and outcome. Long‐term in patients with CCM‐associated analyzed a large single‐center series. Methods Seizure >24 months was available 118 patients. The influence parameters preoperative workup technique regard to seizure Key Findings study cohort comprised 76 drug‐resistant (DRE), 20 chronic that did not meet...
BACKGROUND: Epilepsy is the second most common symptom in cerebral arteriovenous malformation (AVM) patients. The consecutive reduction of life quality a clinically underrated problem because treatment usually focuses on prevention intracerebral hemorrhage. OBJECTIVE: To evaluate postoperative seizure outcome with aim more accurate counseling for outcome. METHODS: From 1985 to 2012, 293 patients an AVM were surgically treated by J.S. One hundred twenty-six preoperative seizures or epilepsy...
Sufficient data on surgical treatment and seizure outcome of pediatric patients with different types epilepsy, especially drug-resistant epilepsy associated cerebral cavernous malformations, are scarce. The aim this study was to carefully evaluate using the International League Against Epilepsy (ILAE) classification regard presurgical symptom duration.Fifty-one younger than 19 years malformations all CNS localizations have been surgically treated at authors' institution. Twenty-two seizures...
The synapses formed by the mossy fiber (MF) axons of hippocampal dentate gyrus granule neurons onto CA3 pyramidal exhibit an intriguing form experience-dependent synaptic plasticity that is induced and expressed presynaptically. In contrast to most other CNS synapses, long-term potentiation (LTP) at MF–CA3 synapse readily even during blockade postsynaptic glutamate receptors. Furthermore, blocking voltage-gated Ca 2+ channels prevents MF-LTP, supporting involvement presynaptic signaling via...
Repetitive painful laser stimuli lead to physiological laser-evoked potential (LEP) habituation, measurable by a decrement of the N2/P2 amplitude. The time course LEP-habituation is reduced in capsaicin model for peripheral and central sensitization patients with migraine fibromyalgia. In present investigation, we aimed assess neuropathic pain syndrome, i.e. radiculopathy.At side radiating pain, four blocks 25 each were applied ventral thigh at L3 dermatome 27 radiculopathy. Inclusion...
Pharmaceutical intervention in the CNS is hampered by shielding function of blood-brain barrier (BBB). To induce clinical anesthesia, general anesthetics such as isoflurane readily penetrate BBB. Here, we investigated whether can be utilized for therapeutic drug delivery.Barrier primary endothelial cells was evaluated transepithelial/transendothelial electrical resistance, and nanoscale STED SRRF microscopy. In mice, BBB permeability quantified extravasation several fluorescent tracers....
Abstract Background Isocitrate dehydrogenase ( IDH)1/2 wildtype (wt) astrocytomas formerly classified as WHO grade II or III have significantly shorter PFS and OS than IDH mutated 2 3 gliomas leading to a classification CNS 4. It is the aim of this study evaluate differences in treatment-related clinical course these tumors they are largely unknown. Methods Patients undergoing surgery (between 2016–2019 six neurosurgical departments) for histologically diagnosed 2–3 IDH1/2-wt astrocytoma...
Isolated traumatic subarachnoid hemorrhage (itSAH) is found in approximately 25% of all patients with mild brain injury (TBI). The aim this study was to analyze the clinical course and identify risk factors for potential radiologic deterioration consideration impaired coagulation itSAH.A retrospective analysis 735 TBI resulting a pathologic computer-assisted tomography (CAT) performed. Only those itSAH Glasgow Coma Scale (GCS) greater than 8 points follow-up CAT scan were included. Patients...
Abstract We describe here 11 consecutive patients with recurrence of high-grade glioma treated regorafenib at our university medical center. The majority had MGMT promoter methylation (9/11 cases). Regorafenib was given as 2nd line systemic treatment in 6/11 and 3rd or higher 5/11 patients. median number applied cycles 2 dosage reductions 5/11. Response to observed 4/11 (PR 1/11, SD 3/11). Median overall survival for the cohort 16.1 months, progression-free 9.0 time failure 3.3 months. Side...