A5013093830- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Cerebrovascular and Carotid Artery Diseases
- Brain Metastases and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Infectious Diseases and Tuberculosis
- Cervical and Thoracic Myelopathy
- Orthopedic Infections and Treatments
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Advanced Neuroimaging Techniques and Applications
- Moyamoya disease diagnosis and treatment
- Hemostasis and retained surgical items
- Nanoplatforms for cancer theranostics
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- MRI in cancer diagnosis
University of Göttingen
2015-2024
Universitätsmedizin Göttingen
2015-2024
Kantonsspital Aarau
2013-2020
University Hospital of Geneva
2009-2020
University Hospital of Basel
2012-2018
University Hospital of Bern
2018
University of Zurich
2018
Ospedale regionale di Lugano
2018
Kantonsspital St. Gallen
2018
University of Toronto
2017
Recent years have been marked by efforts to improve the quality and safety of pedicle screw placement in spinal instrumentation. The aim present study is compare accuracy SpineAssist robot system with conventional fluoroscopy-guided placement.Ninety-five patients suffering from degenerative disease requiring elective lumbar instrumentation were included study. cohort (Group I; 55 patients, 244 screws) consisted an initial open robot-assisted subgroup (Subgroup IA; 17 83 a percutaneous IB, 38...
To develop and validate a set of practical prediction tools that reliably estimate the outcome subarachnoid haemorrhage from ruptured intracranial aneurysms (SAH).Cohort study with logistic regression analysis to combine predictors treatment modality.Subarachnoid Haemorrhage International Trialists' (SAHIT) data repository, including randomised clinical trials, prospective observational studies, hospital registries.Researchers collaborated pool datasets registries, trials SAH multiple...
OBJECTIVE The quest to improve the safety and accuracy decrease invasiveness of pedicle screw placement in spine surgery has led a markedly increased interest robotic technology. SpineAssist from Mazor is one most widely distributed systems. aim this study was compare robot-guided conventional freehand fluoroscopy-guided thoracolumbar surgery. METHODS This retrospective series 169 patients (83 women [49%]) who underwent instrumentation 2007 2015 2 reference centers. Pathological entities...
Background and Purpose— According to the International Study of Unruptured Intracranial Aneurysms (ISUIA), anterior circulation (AC) aneurysms <7 mm in diameter have a minimal risk rupture. It is general experience, however, that communicating artery (AcoA) are frequent mostly rupture at mm. The aim study was assess whether AcoA behave differently from other AC aneurysms. Methods— Information about 932 patients newly diagnosed with intracranial between November 1, 2006, March 31, 2012,...
OBJECTIVE Robot-guided pedicle screw placement is an established technique for the of screws. However, most studies have focused on degenerative disease. In this paper, authors focus metastatic spinal disease, which associated with osteolysis. The lack dense bone may potentially affect automatic recognition accuracy radiography-based surgical assistance systems. aim present study to compare SpineAssist robot system conventional fluoroscopy-guided thoracolumbar METHODS Seventy patients...
Background and Purpose— To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage to estimate their impact. Methods— Retrospective analysis prospective data from a nationwide multicenter registry on all cases admitted tertiary neurosurgical department Switzerland (Swiss SOS [Swiss Study Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). Both clinical radiological independent were identified, effect size was determined by calculating adjusted odds...
Background and Purpose: The purpose of this study was to assess nationwide incidence outcomes aneurysmal subarachnoid hemorrhage (aSAH). Swiss SOS (Swiss Study on Subarachnoid Hemorrhage) established in 2008 offers the unique opportunity provide data from point care a level. Methods: All patients with confirmed admitted between January 1, 2009 December 31, 2014, within Switzerland were recorded prospective registry. Incidence rates calculated based time-matched population data. Admission...
To evaluate whether tumour-derived microvesicles (T-MV), originating from the plasma membrane, represent suitable cancer biomarkers, we isolated MV peripheral blood samples of patients with locally advanced and/or metastatic solid tumours (n = 330, including 79 head & neck cancers, 74 lung 41 breast 28 colorectal cancers and 108 other forms) controls 103). Whole preparations were characterised using flow cytometry. While carrying tumour-associated proteins MUC1, EGFR EpCAM found to be...
Abstract Mutations and activation of the PI3K signaling pathway in breast cancer cells have been linked to brain metastases. However, here we describe that some metastases samples protein expression components is restricted metastatic microenvironment. In contrast therapeutic effects inhibition on cells, reaction microenvironment less understood. Therefore aimed quantify activity metastasis investigate central nervous system (CNS) First, systematically metastases, performed a prospective...
Abstract Objective Glioblastoma with multiple foci (mGBM) and brain metastases share several common features on magnetic resonance imaging (MRI). A reliable preoperative diagnosis would be of clinical relevance. The aim this study was to explore the differences similarities between mGBM MRI. Methods We performed a retrospective analysis 50 patients compared them cohort (2–10 lesions) histologically confirmed treated at our department 2015 2020. following characteristics were analyzed: lesion...
Previous studies have shown the individual benefits of 5-aminolevulinic acid (5-ALA) and intraoperative (i)MRI in enhancing survival for patients with high-grade glioma. In this retrospective study, we compare rates progression-free overall between who underwent surgical resection combination 5-ALA iMRI a control group without iMRI.In 200 consecutive gliomas, recorded age, sex, World Health Organization tumor grade, pre- postoperative Karnofsky performance status (good ≥80 poor <80). A...
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used to evaluate tumor permeability, yet measurements have not been directly validated in brain tumors. Our purpose was compare estimates of forward leakage Ktrans derived from DCE-MRI the K obtained using [14C]aminoisobutyric acid quantitative autoradiography ([14C]AIB OAR), an established method evaluating blood-tumor barrier permeability. Both and [14C]AIB OAR were performed five rats 9 11 days following...
We sought to assess the population-based estimates of age-standardized survival among patients with low-grade gliomas (LGG) and determine impact age time on relative (RS). Data from Surveillance, Epidemiology, End Results (SEER) program NCI 1973 through 2006 were analyzed 5037 patients. Relationships modeled using Dickman's piecewise constant hazards RS model. The 3- 10-year 67% 37%, respectively. When by group, overall (OS) for children (age, <16 years), young adults 16–39 40–64 older ≥65...
The Barrow Neurological Institute (BNI) scale is a novel quantitative measuring maximal subarachnoid hemorrhage (SAH) thickness to predict delayed cerebral ischemia (DCI). This could replace the Fisher score, which was traditionally used for DCI prediction. To validate BNI scale. All patient data were obtained from prospective aneurysmal SAH multicenter registry. In 1321 patients, demographic data, scale, DCI, and modified Rankin Scale (mRS) score up 1-yr follow-up (1FU) available...
Breast cancer has been associated with activation of the WNT signaling pathway, although no driver mutations in genes have found yet. Instead, a high expression alternative receptor ROR2 was observed, particular breast brain metastases. However, its respective ligand and downstream this context remained unknown. We modulated human cells characterized their gene protein by RNA-Seq, qRT-PCR, immunoblots reverse phase array (RPPA) combined network analyses to understand molecular basis cancer....
OBJECTIVE Clipping of a ruptured intracranial aneurysm requires some degree vessel manipulation, which in turn is believed to contribute vasoconstriction. One the techniques used during surgery temporary clipping parent vessel. Temporary may either be mandatory cases premature rupture (rescue) or represent precautionary facilitating surgical step (elective). The aim this study was association between and incidence vasospasm delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage...