A5065482125- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Nerve injury and regeneration
- Head and Neck Surgical Oncology
- Cerebrovascular and Carotid Artery Diseases
- Fetal and Pediatric Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Meningioma and schwannoma management
- Neonatal and fetal brain pathology
- Moyamoya disease diagnosis and treatment
- Laser Applications in Dentistry and Medicine
- Craniofacial Disorders and Treatments
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Acute Ischemic Stroke Management
- Surgical Simulation and Training
- Cancer Cells and Metastasis
University Hospital of Basel
2016-2025
University of Basel
2015-2025
University Children’s Hospital Basel
2016-2025
University of Fribourg
2023
University College Cork
2023
Hospital Base
2013-2023
Temple Street Children's University Hospital
2019-2022
Yale University
2022
NYU Langone Health
2022
Faculty (United Kingdom)
2021
Object Moyamoya disease (MMD) is a rare cerebrovascular mainly described in the Asian literature. To address lack of data on clinical characteristics and long-term outcomes treatment MMD North America, authors analyzed their experience at Stanford University Medical Center. They report consecutive series patients treated for detail demographics, characteristics, surgical outcomes. Methods Data obtained 329 with microsurgically by senior author (G.K.S.) between 1991 2008 were analyzed....
Noninvasive monitoring of stem cells, using high-resolution molecular imaging, will be instrumental to improve clinical neural transplantation strategies. We show that labeling human central nervous system cells grown as neurospheres with magnetic nanoparticles does not adversely affect survival, migration, and differentiation or alter neuronal electrophysiological characteristics. Using MRI, we transplanted either the neonatal, adult, injured rodent brain respond cues characteristic for...
We have developed a method for embedding cells within collagen matrix which allows sustained growth of mouse mammary tumor epithelial in primary culture. A characteristic and reproducible pattern organization occurs: the rearrange themselves produce duct-like structures extending into matrix, resulting three-dimensional outgrowth. Autoradiography showed continuous [3H]thymidine incorporation during 8 weeks An increase DNA content cultured as function time was observed. Mouse conventional...
Growing evidence links COVID-19 with acute and long-term neurological dysfunction. However, the pathophysiological mechanisms resulting in central nervous system involvement remain unclear, posing both diagnostic therapeutic challenges. Here we show outcomes of a cross-sectional clinical study (NCT04472013) including imaging data corresponding multidimensional characterization immune mediators cerebrospinal fluid (CSF) plasma patients belonging to different Neuro-COVID severity classes. The...
Thrombospondins 1 and 2 (TSP-1/2) belong to a family of extracellular glycoproteins with angiostatic synaptogenic properties. Although TSP-1/2 have been postulated drive the resolution postischemic angiogenesis, their role in synaptic functional recovery is unknown. We investigated whether are necessary for motor after stroke. Focal ischemia was induced 8- 12-week-old wild-type (WT) knockout (KO) mice by unilateral occlusion distal middle cerebral artery common carotid (CCA). increased...
Normal mammary epithelial cells from BALB/cfC3H midpregnant mice were freed stromal cell types by Percoll density gradient centrifugation after collagenase digestion and then embedded within collagen gels. Sustained growth leading to an increase in number was accomplished response cholera toxin high concentrations of horse serum. The extent found be dependent on the serum concentration, maximum being attained at 50%. A concentration 12.5% 2.5% fetal calf serum, along with 0.01 μg/ml, allowed...
Intravascular transplantation of neural stem cells represents a minimally invasive therapeutic approach for the treatment central nervous system diseases. The cellular biodistribution after intravascular injection needs to be analyzed determine ideal delivery modality. We studied and efficiency targeted comparing intravenous intra-arterial (IA) administration brain ischemia.Mouse were transduced with firefly luciferase reporter gene bioluminescence imaging (BLI). Hypoxic-ischemia was induced...
Sustained growth of normal mouse mammary epithelial cells in primary culture, leading to an increase cell number, response factors [epidermal factor (EGF) and fibroblast (FGF)] or cholera toxin has been achieved by embedding the inside collagen cells. Inclusion agents known level cellular cAMP have found be favorable for proliferation. Cholera is far best all tested (prostaglandins E,sub>1 E2, isoproterenol, theophylline, dibutyryl cAMP). When (EGF FGF) are added with toxin, a synergistic...
Successful management of pediatric arteriovenous malformations (AVMs) often requires a balanced application embolization, surgery, and radiosurgery.To describe our experience treating AVMs.We analyzed 120 patients (< 18 years age) with AVMs treated various combinations radiosurgery, endovascular techniques.Between 1985 2009, 76 children low Spetzler-Martin grade (1-3) 44 high-grade (4-5) were treated. Annual risk hemorrhage from presentation to initial treatment was 4.0%, decreasing 3.2%...
Human central nervous system stem cells (HuCNS-SC) are multipotent adult with successful engraftment, migration, and region-appropriate differentiation after spinal cord injury (SCI).To present data on the surgical safety profile feasibility of multiple intramedullary perilesional injections HuCNS-SC SCI.Intramedullary free-hand (manual) transplantation was performed in subjects thoracic (n = 12) cervical 17) complete sensory incomplete chronic traumatic cell needle times cohort (20 M...
Background and Purpose— To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage to estimate their impact. Methods— Retrospective analysis prospective data from a nationwide multicenter registry on all cases admitted tertiary neurosurgical department Switzerland (Swiss SOS [Swiss Study Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). Both clinical radiological independent were identified, effect size was determined by calculating adjusted odds...
Abstract BACKGROUND The use of a subdural drain (SDD) after burr-hole drainage chronic hematoma (cSDH) reduces recurrence at 6 mo. Subperiosteal drains (SPDs) are considered safer, since they not positioned in direct contact to cortical structures, bridging veins, or membranes. OBJECTIVE To investigate whether the rate insertion SPD is noninferior more commonly used SDD. METHODS Multicenter, prospective, randomized, controlled, noninferiority trial analyzing patients undergoing for cSDH aged...
Abstract Hypoxic ischemia (HI) is an acute brain threat across all age groups. Therapeutic hypothermia ameliorates resulting injury in neonates but its side effects prevent routine use adults. Hypothermia up-regulates a small protein subset that includes RNA-binding motif 3 (RBM3), which neuroprotective under stressful conditions. Here we show how RBM3 stimulates neuronal differentiation and inhibits HI-induced apoptosis the two areas of persistent adult neurogenesis, subventricular zone...
Background and Purpose: The purpose of this study was to assess nationwide incidence outcomes aneurysmal subarachnoid hemorrhage (aSAH). Swiss SOS (Swiss Study on Subarachnoid Hemorrhage) established in 2008 offers the unique opportunity provide data from point care a level. Methods: All patients with confirmed admitted between January 1, 2009 December 31, 2014, within Switzerland were recorded prospective registry. Incidence rates calculated based time-matched population data. Admission...
Evidence-based hemostatic treatment for intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOACs) is lacking. Tranexamic acid (TXA) an antifibrinolytic drug potentially limiting hematoma expansion. We aimed to assess the efficacy and safety of TXA in NOAC-ICH.We performed a double-blind, randomized, placebo-controlled trial at 6 Swiss stroke centers. Patients NOAC-ICH within 12 hours symptom onset 48 last NOAC intake were randomized (1:1) receive...
Abstract DNA methylation analysis based on supervised machine learning algorithms with static reference data, allowing diagnostic tumour typing unprecedented precision, has quickly become a new standard of care. Whereas genome-wide profiling is mostly performed microarrays, an increasing number institutions additionally employ nanopore sequencing as faster alternative. In addition, methylation-specific parallel can generate and genomic copy data. Given these diverse approaches to profiling,...
This paper describes a 3D electromagnetic tracking (EMT) system, based on quasi-static magnetic fields and sub-millimeter magnetometer, providing complete localization - both spatial angular positions during surgical procedures. By integrating miniaturized sensors into tools, such as deep brain stimulation (DBS) electrodes, this system offers complementary or alternative solutions for X-ray imaging. Each position in the measurement volume (MV) is uniquely encoded by vector of four field...
The cerebellum of the weanling piglet (Yorkshire) was used as a surrogate for radiosensitive human infant in Swiss-led program experimental microbeam radiation therapy (MRT) at ESRF. Five weanlings 47 day old litter seven, and eight 40 eleven were irradiated November, 1999 June, 2000, respectively. A 1.5 cm-wide x xm-high array equally space approximately equals 20-30 micrometers wide, upright microbeams spaced 210 intervals propagated horizontally, left to right, through cerebella prone,...
Background and Purpose— Intravascular delivery of neural stem cells (NSCs) after stroke has been limited by the low efficiency transendothelial migration. Vascular cell adhesion molecule-1 is an endothelial molecule known to be upregulated early responsible for firm inflammatory expressing surface integrin, CD49d. We hypothesize that enriching NSCs express CD49d injecting them into carotid artery would improve targeted injured brain. Methods— Mouse were analyzed expression fluorescence...