A5056255583- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Multiple Sclerosis Research Studies
- EEG and Brain-Computer Interfaces
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Transcranial Magnetic Stimulation Studies
- Acute Ischemic Stroke Management
- Neuroscience and Music Perception
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Neural dynamics and brain function
- Trigeminal Neuralgia and Treatments
- Neural and Behavioral Psychology Studies
- Atomic and Subatomic Physics Research
- Hearing Loss and Rehabilitation
- Facial Nerve Paralysis Treatment and Research
- MRI in cancer diagnosis
- Neurobiology of Language and Bilingualism
- Motor Control and Adaptation
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Spinal Dysraphism and Malformations
Allensbach Institute
2024
Kliniken Schmieder
2021-2023
University Hospital of Zurich
2018-2021
University of Zurich
2018-2021
University Hospital of Basel
2011-2020
University of Basel
2010-2020
Helios Kliniken
2018
Christophorus Kliniken
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2017
University Medical Center Utrecht
2017
Impaired cognitive-behavioral flexibility is regarded as a trait marker in anorexia nervosa patients. The authors sought to investigate the neural correlates of this deficit executive functioning nervosa.Fifteen women with and 15 age-matched healthy comparison underwent event-related functional MRI while performing target-detection task. task distinguished between shifts behavioral response cognitive set. It involved infrequent target non-target distractor stimuli embedded sequence prepotent...
Summary: Purpose: Simultaneous interictal EEG and magnetoencephalography (MEG) recordings were used for noninvasive analysis of epileptogenicity in focal cortical dysplasia (FCD). The results two different approach methods (multiple source averaged spikes single dipole peak localization spikes) compared with pre‐ postoperative anatomic magnetic resonance imaging (MRI). Patients: We studied nine children adolescents (age, 3.5–15.9 years) localization‐related epilepsy FCD diagnosis based on...
Chronic subthreshold stimulation of the contralateral precentral gyrus is used in patients with intractable neuropathic pain for more than 15 years. The aim this study was to analyse retrospectively our own patient group long term follow-up 10 Seventeen chronic were treated epidural electrodes. In cases, trigeminal (TNP) and seven cases post-stroke (PSP) diagnosed. placement electrodes performed local anaesthesia using neuronavigation intraoperative neuromonitoring. A test trial minimum one...
Background: Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it relevant to how we monitor and treat the disease. Objectives: The Magnetic Imaging MS (MAGNIMS) collaborative group sought determine relationship brain lesion load, spinal cord atrophy, with physical patients long-established MS. Methods: Patients had magnetic resonance imaging (MRI) scan their cord, from which determined grey (GMF) white matter (WMF) fractional volumes, upper cervical...
Absolute pitch (AP) perception is the auditory ability to effortlessly recognize of any given tone without external reference. To study neural substrates this rare phenomenon, we developed a novel behavioral test, which excludes memory-based interval recognition and permits quantification AP proficiency independently relative cues. AP- non-AP-possessing musicians were studied with morphological functional magnetic resonance imaging (fMRI) magnetoencephalography. Gray matter volume right...
Background and Purpose: Case series indicating cerebrovascular disorders in coronavirus disease 2019 (COVID-19) have been published. Comprehensive workups, including clinical characteristics, laboratory, electroencephalography, neuroimaging, cerebrospinal fluid findings, are needed to understand the mechanisms. Methods: We evaluated 32 consecutive critically ill patients with COVID-19 treated at a tertiary care center from March 9 April 3, 2020, for concomitant severe central nervous system...
Evidence-based hemostatic treatment for intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOACs) is lacking. Tranexamic acid (TXA) an antifibrinolytic drug potentially limiting hematoma expansion. We aimed to assess the efficacy and safety of TXA in NOAC-ICH.We performed a double-blind, randomized, placebo-controlled trial at 6 Swiss stroke centers. Patients NOAC-ICH within 12 hours symptom onset 48 last NOAC intake were randomized (1:1) receive...
Purpose: To prospectively assess the feasibility of standardized presurgical functional magnetic resonance (MR) imaging for localizing Broca and Wernicke areas lateralizing language function. Materials Methods: The study was approved by responsible ethics commission, patients gave written informed consent. Eighty-one (36 female 45 male patients; age range, 7–75 years) with different brain tumors underwent blood oxygen level–dependent MR at 1.5 T two paradigms: sentence generation (SG) word...
Reliable imaging of eloquent tumour-adjacent brain areas is necessary for planning function-preserving neurosurgery. This study evaluates the potential diagnostic benefits presurgical functional magnetic resonance (fMRI) in comparison to a detailed analysis morphological MRI data.Standardised preoperative and structural neuroimaging was performed on 77 patients with rolandic mass lesions at 1.5 Tesla. The central region both hemispheres allocated using six three landmarks.fMRI enabled...
The cerebellum is known to be involved not only in motor but also cognitive and affective processes. Structural changes the relation dysfunction are an emerging topic field of neuro-psychiatric disorders. In Multiple Sclerosis (MS) cerebellar occur parallel, early onset disease, one predilection sites atrophy. This study aimed at determining relationship between volumes, clinical signs, functioning fatigue MS. Cerebellar volumetry was conducted using T1-weighted MPRAGE magnetic resonance...
Cross-sectional studies have shown that spinal cord volume (SCV) loss is related to disease severity in multiple sclerosis (MS). However, long-term data are lacking. Our aim was evaluate SCV as a biomarker of progression comparison other MRI measurements large cohort patients with relapse-onset MS 6-year follow-up.The upper cervical SCV, the total brain volume, and T2 lesion were measured annually 231 (180 relapsing-remitting [RRMS] 51 secondary progressive [SPMS]) over 6 years on...
Several studies found that patients with atrial fibrillation (AF) have an increased risk of cognitive decline and dementia over time. However, the magnitude problem, associated factors underlying mechanisms remain unclear.This article describes design methodology Swiss Atrial Fibrillation (Swiss-AF) Cohort Study, a prospective multicentre national cohort study 2400 across 13 sites in Switzerland. Eligible must documented AF. Main exclusion criteria are inability to provide informed consent...
Abstract The goal of this study was to evaluate the feasibility active deep brain stimulation (DBS) during application standard clinical sequences for functional MRI (fMRI) in phantom measurements. During DBS, we investigated induced voltage, temperature at electrode tips and lead, forces on consequences defective leads loose connections, proper operation neurostimulator, image quality. Sequences diffusion‐ perfusion‐weighted imaging, fMRI, morphologic were used. DBS lead placed a NaCl...
We studied the trigeminal nerve in seven healthy volunteers and six patients with neuralgia using diffusion tensor imaging derived parameter fractional anisotropy (FA). While controls did not show a difference between both sides, there was reduction of FA affected three accompanying nerve-vessel conflict atrophy. Reversibility abnormally low values demonstrated one patient successfully treated microvascular decompression.
Brain tumors affecting language-relevant areas may influence language lateralization. The purpose of this study was to systematically investigate lateralization in brain tumor patients using clinical fMRI, comparing the results with a group healthy volunteers.Fifty-seven strictly right-handed left-hemispheric-space intracranial masses (mainly neoplastic) either Broca area (n = 19) or Wernicke 38) were prospectively enrolled study. Fourteen volunteers served as control group. Standardized...
Strong memory of a traumatic event is thought to contribute the development and symptoms posttraumatic stress disorder (PTSD). Therefore, genetic predisposition build strong memories could lead increased risk for PTSD after event. Here we show that variability gene encoding PKCα ( PRKCA ) was associated with capacity—including aversive memory—in nontraumatized subjects European descent. This finding replicated in an independent sample subjects, who additionally underwent functional magnetic...