A5076894759- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Vitamin D Research Studies
- Atrial Fibrillation Management and Outcomes
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Medication Adherence and Compliance
- Bone health and osteoporosis research
- Neuroscience of respiration and sleep
- Transplantation: Methods and Outcomes
- Heart Failure Treatment and Management
- Air Quality and Health Impacts
- Migraine and Headache Studies
- Influenza Virus Research Studies
- Venous Thromboembolism Diagnosis and Management
- Mycobacterium research and diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Ion channel regulation and function
- Acute Ischemic Stroke Management
University of Bern
2015-2025
University Hospital of Bern
2009-2024
University of Basel
2011-2024
University of Fribourg
2024
University of Lausanne
2024
University of Zurich
2024
Sorbonne Université
2024
Centre universitaire de médecine générale et santé publique, Lausanne
2024
Centre Val de Loire
2021
Leiden University
2018
The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed determine whether provided clinical benefits in older persons with this condition.
Abstract Clinical question What are the benefits and harms of thyroid hormones for adults with subclinical hypothyroidism (SCH)? This guideline was triggered by a recent systematic review randomised controlled trials, which could alter practice. Current practice guidelines tend to recommend stimulating hormone (TSH) levels >10 mIU/L people lower TSH values who young, symptomatic, or have specific indications prescribing. Recommendation The panel issues strong recommendation against in SCH...
Abstract Objective To examine the effect of optimising drug treatment on related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting 110 clusters inpatient wards within university based hospitals four European countries (Switzerland, Netherlands, Belgium, Republic Ireland) defined by attending doctors. Participants 2008 (≥70 years) (≥3 chronic conditions) (≥5 drugs used long term). Intervention...
Electronic nicotine-delivery systems - also called e-cigarettes are used by some tobacco smokers to assist with quitting. Evidence regarding the efficacy and safety of these is needed.
Data on the association between subclinical thyroid dysfunction and dementia are limited conflicting. We aimed to determine whether was associated with cognitive decline.
Objective Guidelines for thyroid function evaluation recommend testing TSH first, then assessing fT4 only if is out of the reference range (two-step), but many clinicians initially request both and (one-step). Given limitations previous studies, we aimed to compare two-step with one-step approach in an unselected community-dwelling study population, develop a prediction score based on clinical parameters that could identify at-risk patients dysfunction. Design Cross-sectional analysis...
Abstract Background As populations are aging, the number of older patients with multiple chronic diseases demanding complex care increases. Although clinical guidelines recommend to be personalized accounting for life expectancy, there no tools estimate expectancy among multimorbid patients. Our objective was therefore develop and internally validate a estimator specifically adults. Methods We analyzed data from OPERAM (OPtimising thERapy prevent avoidable hospital admissions in people)...
Previous studies on childhood cancer and nuclear power plants (NPPs) produced conflicting results. We used a cohort approach to examine whether residence near NPPs was associated with leukaemia or any in Switzerland.
Introduction Multimorbidity and polypharmacy are important risk factors for drug-related hospital admissions (DRAs). DRAs often linked to prescribing problems (overprescribing underprescribing), as well non-adherence with drug regimens different reasons. In this trial, we aim assess whether a structured medication review compared standard care can reduce in multimorbid older patients polypharmacy. Methods analysis OPtimising thERapy prevent Avoidable Multimorbid people is European...
Subclinical hypothyroidism has been associated with heart failure, but only small trials assessed whether treatment levothyroxine an impact on cardiac function.In a randomized, double-blind, placebo-controlled, trial nested within the TRUST trial, Swiss participants ages ≥65 years subclinical (thyroid-stimulating hormone [TSH] 4.60-19.99 mIU/L; free thyroxine level reference range) were randomized to (starting dose of 50 µg daily) achieve TSH normalization or placebo. The primary outcomes...
Abstract Context Subclinical hypothyroidism (SHypo) has been associated with atherosclerosis, but no conclusive clinical trials assessing the levothyroxine impact on carotid atherosclerosis exist. Objective To assess of treatment SHypo atherosclerosis. Design and Setting Randomized, double-blind, placebo-controlled trial nested within Thyroid Hormone Replacement for Hypothyroidism trial. Participants aged ≥65 years [thyroid-stimulating hormone (TSH), 4.60 to 19.99 mIU/L; free thyroxine level...
<h3>Importance</h3> Previous trials on the effect of levothyroxine depressive symptom scores in patients with subclinical hypothyroidism were limited by small sample sizes (N = 57 to 94) and potential biases. <h3>Objective</h3> To assess development symptoms older adults largest trial this subject update a previous meta-analysis including results from study. <h3>Design, Setting, Participants</h3> This predefined ancillary study analyzed data participants Thyroid Hormone Replacement for...
Abstract Background Several approaches to medication optimisation by identifying drug-related problems in older people have been described. Although some interventions shown reductions (DRPs), evidence supporting the effectiveness of reviews on clinical and economic outcomes is lacking. Application STOPP/START (version 2) explicit screening tool for inappropriate prescribing has decreased significantly reduced adverse drug reactions (ADRs) associated healthcare costs patients with...
Background: L-thyroxine does not improve hypothyroid symptoms among adults with subclinical hypothyroidism (SCH). However, those greater symptom burden before treatment may still benefit. Objective: To determine whether improves and tiredness older SCH burden. Design: Secondary analysis of the randomized, placebo-controlled trial TRUST (Thyroid Hormone Replacement for Untreated Older Adults Subclinical Hypothyroidism Trial). (ClinicalTrials.gov: NCT01660126) Setting: Switzerland, Ireland,...
<h3>Importance</h3> The most appropriate therapy for older adults with multimorbidity may depend on life expectancy (ie, mortality risk), and several scores have been developed to predict 1-year risk. However, often, these risk not externally validated in large sample sizes, a head-to-head comparison prospective contemporary cohort is lacking. <h3>Objective</h3> To prospectively compare the performance of 6 predicting hospitalized multimorbidity. <h3>Design, Setting, Participants</h3> This...
Oxidative stress can contribute to the development of diseases, and may originate from exposures toxicants commonly found in air pollution cigarette smoke such as polycyclic aromatic hydrocarbons (PAHs) volatile organic compounds (VOCs). Yet, associations between these oxidative biomarkers are poorly characterized. We report here novel 14 exposure PAHs VOCs, two biomarkers; 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) 8-isoprostaglandin F2α (8-isoprostane) urine obtained smokers...
Abstract Background loss of skeletal muscle function, strength and mass is common in older adults, with important socioeconomic impacts. Subclinical hypothyroidism increasing age has been associated reduced strength. Yet, no randomized placebo-controlled trial (RCT) investigated whether treatment subclinical affects function mass. Methods this an ancillary study within two RCTs conducted among adults aged ≥65 years persistent (thyrotropin (TSH) 4.60–19.99 mIU/l, normal free thyroxine)....