A5017421765- Multiple Sclerosis Research Studies
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Polyomavirus and related diseases
- Advanced Neuroimaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- Cardiac Imaging and Diagnostics
- Peripheral Neuropathies and Disorders
- Systemic Sclerosis and Related Diseases
- Retinal and Optic Conditions
- RNA regulation and disease
- CNS Lymphoma Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Cardiac Arrhythmias and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Atomic and Subatomic Physics Research
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Glioma Diagnosis and Treatment
University of Basel
2018-2025
University Hospital of Basel
2016-2025
Charité - Universitätsmedizin Berlin
2012-2020
Max Delbrück Center
2012-2020
Centre d'Imagerie BioMedicale
2019
Freie Universität Berlin
2018-2019
Humboldt-Universität zu Berlin
2018-2019
Klinikum Görlitz
2015-2016
Asklepios
2014-2016
University of Southern Denmark
2016
The central vein sign has been proposed as a specific imaging biomarker for distinguishing between multiple sclerosis (MS) and not MS, mainly based on findings from ultrahigh-field magnetic resonance (MRI) studies. diagnostic value of the in multicenter setting with variety clinical 3 tesla (T) MRI protocols, however, remains unknown.To evaluate sensitivity specificity various lesion criteria differentiating MS non-MS conditions using 3T brain commonly used pulse sequences.This large...
<h3>Importance</h3> The mechanisms driving neurodegeneration and brain atrophy in relapsing multiple sclerosis (RMS) are not completely understood. <h3>Objective</h3> To determine whether disability progression independent of relapse activity (PIRA) patients with RMS is associated accelerated tissue loss. <h3>Design, Setting, Participants</h3> In this observational, longitudinal cohort study median (IQR) follow-up 3.2 years (2.0-4.9), data were acquired from January 2012 to September 2019 a...
To investigate distinct white matter and cortical gray pathology in neuromyelitis optica spectrum disorders (NMOSDs) multiple sclerosis (MS) at 7-T MRI a cross-sectional study.We included 10 patients with NMOSDs 18 MS our study. The imaging protocol comprised T2*-weighted fast low angle shot turbo inversion recovery magnitude sequences. White lesions were assessed special regard to their (perivascular) localization as well the expression of hypointense rim.In total, we detected 140 7 NMOSDs....
Background: Although an orphan disease with still obscure aetiopathogenesis, Susac syndrome has to be considered as differential diagnosis in multiple sclerosis (MS), since its clinical presentation and paraclinical features including routine magnetic resonance imaging (MRI) findings partially overlap. Objective: We aimed study a potential benefit of 7T MRI for (i) the differentiation between MS (ii) clarification pathogenesis syndrome. Methods: Five patients suffering from syndrome, 10 sex-...
Abstract Aims We aimed to investigate the association of clinically overt and silent brain lesions with cognitive function in atrial fibrillation (AF) patients. Methods results enrolled 1227 AF patients a prospective, multicentre cohort study (Swiss-AF). Patients underwent standardized magnetic resonance imaging (MRI) at baseline after 2 years. quantified new small non-cortical infarcts (SNCIs) large or cortical (LNCCIs), white matter (WML), microbleeds (Mb). Clinically, were defined as...
The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the similarly involved MS and neuromyelitis optica spectrum disorder (NMOSD). Thus, aim of this study was compare volume NMOSD.In retrospective, cross-sectional study, patients were included by convenience sampling from 4 international centers. lateral ventricles segmented fully automatically on...
White matter lesions (WMLs) on brain magnetic resonance imaging (MRI) in multiple sclerosis (MS) may contribute to misdiagnosis. In chronic active lesions, peripheral iron-laden macrophages appear as paramagnetic rim (PRLs).To evaluate the sensitivity and specificity of PRLs differentiating MS from mimics using clinical 3T MRI scanners.This retrospective international study reviewed scans patients with (n = 254), 91) older healthy controls 217). WMLs, detected fluid-attenuated inversion...
In current clinical practice, T2-weighted magnetic resonance imaging (MRI) is commonly applied to quantify the accumulated multiple sclerosis (MS)lesion load, whereas T1-weighted sequences are used differentiate edema, blood-brain barrier breakdown by contrast enhancement, and irreversible brain tissue damage(commonly called “black holes” owing loss of signal intensity in sequences). Black holes histopathologically associated with axonal severe destruction. addition, double inversion...
Characterization of iron deposition associated with demyelinating lesions multiple sclerosis and neuromyelitis optica has not been well studied. Our aim was to investigate the potential ultra-high-field MR imaging distinguish MS from characterize tissue injury pathology within lesions.Twenty-one patients 21 underwent 7T high-resolution 2D-gradient-echo-T2* 3D-susceptibility-weighted imaging. An in-house-developed algorithm used reconstruct quantitative susceptibility mapping SWI. Lesions...
Objective Trimethylamine-N-oxide (TMAO) is a metabolite derived from the microbial processing of dietary phosphatidylcholine and carnitine subsequent hepatic oxidation. Due to its prothrombotic inflammatory mechanisms, we aimed assess role in prediction adverse events susceptible population, namely patients with atrial fibrillation. Methods Baseline TMAO plasma levels were measured by liquid chromatography-tandem mass spectrometry 2379 subjects ongoing Swiss Atrial Fibrillation cohort. 1722...
Background: Damage to venules in multiple sclerosis was first described decades ago. Today, ultrahigh magnetic field strength T2*-weighted resonance imaging (MRI) techniques depict very small cerebral veins vivo with great anatomical detail. Objective: We aimed investigate alterations of periventricular blood vessel appearance relation T2 lesion count and distribution clinically isolated syndrome comparison healthy control subjects at 7 Tesla MRI. Methods: investigated 38 patients (including...
To characterize paramagnetic MRI phase signal abnormalities in neuromyelitis optica spectrum disorder (NMOSD) vs multiple sclerosis (MS) lesions a cross-sectional study.Ten patients with NMOSD and 10 relapsing-remitting MS underwent 7-tesla brain including supratentorial T2*-weighted imaging susceptibility weighted imaging. Next, we analyzed intra- perilesional changes on filtered magnetic resonance images.We frequently observed rim-like (75 of 232 lesions, 32%) or nodular (32 14%) but only...
Brain lesions with a hypointense ring or core were described in multiple sclerosis on susceptibility weighted imaging.The purpose of this study was to the evolution and prognostic relevance imaging clinically isolated syndrome early sclerosis.Sixty-six patients followed over median period 2.9 years (range 1.6-4.6 years) underwent 3T magnetic resonance including 3D T2-weighted fluid-attenuated inversion recovery. We assessed presence lesions, Expanded Disability Status Scale at baseline...
To examine if there is widespread inflammation in the brain of patients with chronic lymphocytic pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome by using histology and ultra-high-field MRI at 7.0T.We performed a detailed neuropathologic examination 4 cases, including 1 autopsy case, studied 2 additional 7.0T (1) extension areas appearing normal on 3.0T MRI, (2) potential advantages compared reflecting inflammation, pathology, axonal damage, (3) possibility...
Potential differences between primary progressive (PP) and relapsing–remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology distribution in patients with PPMS RRMS (nine each group) using 7 T MRI. We found that gray white matter lesions did not differ their respective morphological characteristics (e.g. perivascular p = 0.863, hypointense rim 0.796, cortical count 0.436). Although limited by a small sample size, our study...
Pathophysiology of multiple sclerosis (MS) lesions is dynamic and changes over time. The purpose this exploratory study was to determine the longitudinal in MS time on ultra-high field MR imaging. Nine patients with underwent high-resolution 3D-susceptibility weighted imaging (SWI) 2D-gradient-echo-T2*-weighted 7T MRI at baseline after ~2.4 years follow-up. Morphologic characteristics, signal intensity patterns quantitative susceptibility mapping (QSM) values were recorded both points....
Abstract Emerging evidence suggests that atrial fibrillation is associated with cognitive dysfunction independently of stroke, but the underlying mechanisms remain unclear. In this cross-sectional analysis from Swiss-atrial Study (NCT02105844), we investigated association serum neurofilament light protein, a neuronal injury biomarker, (i) CHA2DS2-VASc score (congestive heart failure, hypertension, age 65–74 or &gt;75 years, diabetes mellitus, stroke transient ischaemic attack, vascular...
To determine the risk of subsequent adverse clinical outcomes in anticoagulated patients with atrial fibrillation (AF) who experienced a new bleeding event.Anticoagulated AF were followed two prospective cohort studies. Information on incident was systematically collected during yearly follow-up visits and events adjudicated as major or clinically relevant non-major (CRNMB) according to International Society Thrombosis Haemostasis guidelines. The primary outcome composite stroke, myocardial...
Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a mitochondrial cytopathy caused by mutations in DNA. Clinical manifestation typically before the age of 40. We present case 63-year-old female whom symptoms MELAS were initially misdiagnosed as recurrent ischemic strokes. Brain imaging including MRI, clinical laboratory findings that lent cues to diagnosis are discussed. In addition, MRI comparison mimics presented. This underscores importance considering...
Objective We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes reflecting inflammatory activity chronic worsening. Methods compared cerebrospinal fluid analysis, clinical magnetic resonance imaging data, serum neurofilament light chain (sNfL) levels at baseline follow‐up 530 patients MS. Patients were categorized by the presence oligoclonal bands (OCGB) IgM (intrathecal fraction [IF]: IF )....
ABSTRACT Disorders of the central nervous system, including neurodegenerative diseases, frequently affect brainstem and can present with focal atrophy. This study aimed to (1) optimize deep learning‐based segmentation for a wide range pathologies T1‐weighted image acquisition parameters, (2) conduct systematic technical clinical validation, (3) improve quality in presence lesions, (4) make an optimized tool available public use. An intentionally heterogeneous ground truth dataset ( n = 257)...