A5061230192- Multiple Sclerosis Research Studies
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peripheral Neuropathies and Disorders
- Neurological disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- RNA modifications and cancer
- Advanced Neuroimaging Techniques and Applications
- Cervical and Thoracic Myelopathy
- Infectious Diseases and Tuberculosis
- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- RNA Research and Splicing
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cerebral Venous Sinus Thrombosis
- Spinal Dysraphism and Malformations
- Acute Ischemic Stroke Management
- Infective Endocarditis Diagnosis and Management
- Spinal Cord Injury Research
- Cardiovascular Effects of Exercise
University Hospital of Basel
2018-2025
University of Basel
2019-2025
University Medical Center Freiburg
2024
University of Freiburg
2024
St. Claraspital
2018
Universität Hamburg
2015-2017
University Medical Center Hamburg-Eppendorf
2015-2017
University of Lübeck
2015
King's College London
2015
Cardiac troponin (cTn) T and cTnI are considered cardiac specific equivalent in the diagnosis of acute myocardial infarction. Previous studies suggested rare skeletal myopathies as a noncardiac source cTnT. We aimed to confirm reliability/cardiac specificity cTnT patients with various muscle disorders (SMDs).We prospectively enrolled presenting muscular complaints (≥2 weeks) for elective evaluation 4 hospitals 2 countries. After workup, were adjudicated into 3 predefined disease categories....
The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the similarly involved MS and neuromyelitis optica spectrum disorder (NMOSD). Thus, aim of this study was compare volume NMOSD.In retrospective, cross-sectional study, patients were included by convenience sampling from 4 international centers. lateral ventricles segmented fully automatically on...
Abstract Background and purpose In amyotrophic lateral sclerosis (ALS), there is an unmet need for more precise patient characterization through quantitative, ideally operator‐independent, assessments of disease extent severity. Radially sampled averaged magnetization inversion recovery acquisitions (rAMIRA) magnetic resonance imaging enables gray matter (GM) white (WM) area quantitation in the cervical thoracic spinal cord (SC) with optimized contrast. We aimed to investigate rAMIRA‐derived...
Abstract Neurodegenerative disorders, such as Alzheimer's disease (AD) and progressive forms of multiple sclerosis (MS), can affect the brainstem are associated with atrophy that be visualized by MRI. Anatomically accurate, large‐scale assessments challenging due to lack automated, accurate segmentation methods. We present a novel method for volumetry using fully‐automated approach based on multi‐dimensional gated recurrent units (MD‐GRU), deep learning semantic employing convolutional...
Abstract Background With the approval of disease-modifying treatments for 5q-spinal muscular atrophy (SMA), there is an increasing need biomarkers disease course and therapeutic response monitoring. Radially sampled Averaged Magnetization Inversion Recovery Acquisitions (rAMIRA) MR-imaging enables spinal cord (SC) gray matter (GM) delineation quantification in vivo. This study aims to assess SC GM patients with 5q-SMA its associations clinical disability. Methods Twenty-one twenty-one age-...
ABSTRACT There is an urgent need for reliable magnetic resonance imaging (MRI) biomarkers the diagnosis, prognosis or therapy management of amyotrophic lateral sclerosis (ALS). The aim this study was to explore potential ALS by conducting postmortem (PM) in situ MRI, allowing a non‐invasive evaluation disease's end‐stage without effects formalin fixation. PM MRI whole‐brain scans five deceased patients with clinically definite and seven healthy controls (HC) known neurological disorders were...
Background Radially sampled averaged magnetization inversion-recovery acquisition (rAMIRA) imaging shows hyperintensity in the lateral corticospinal tract (CST) patients with motor neuron diseases. Purpose To systematically determine accuracy of sign for detecting amyotrophic sclerosis (ALS) at rAMIRA MRI. Materials and Methods This study included prospectively acquired data from participants ALS other disease studies University Hospital Basel, Switzerland. All underwent 3-T axial...
Abstract Objective To determine if patients with post‐polio syndrome (PPS) show spinal cord gray matter (SCGM) atrophy and to assess associations between SCGM atrophy, muscle strength patient‐reported functional decline. Methods Twenty diagnosed PPS (March of Dimes criteria) 20 age‐ sex‐matched healthy controls (HC) underwent 3T axial 2D‐rAMIRA magnetic resonance imaging at the intervertebral disc levels C2/C3–C6/C7, T9/T10 lumbar enlargement level ( T max ) (0.5 × 0.5 mm 2 in‐plane...
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system. Fatigue a common disabling symptom, often causing decreased quality life, social withdrawal, unemployment. We developed studied feasibility cognitive-behavioral group intervention to manage fatigue in MS. aimed integrate concepts therapy evidence-based patient information.We conducted interviews focus assess patients' interest need for self-management training program accordingly. The...
Background: MR imaging of the spinal cord (SC) gray matter (GM) at cervical and lumbar enlargements' level may be particularly informative in lower motor neuron disorders, e. g., muscular atrophy, but also other neurodegenerative or autoimmune diseases affecting SC. Radially sampled averaged magnetization inversion recovery acquisition (rAMIRA) is a novel approach to perform SC clinical settings with favorable contrast well-suited for GM quantitation. However, before applying rAMIRA studies,...
Dark chocolate is claimed to have effects on gastrointestinal function and improve well-being. This randomised controlled study tested the hypothesis that cocoa slows gastric emptying intestinal transit. Functional brain imaging identified central of cortical activity. Healthy volunteers (HV) ingested 100 g dark (72 % cocoa) or white (0 for 5 d, in order. Participants recorded abdominal symptoms stool consistency by Bristol Stool Score (BSS). Gastric (GE) colonic transit time were assessed...
Abstract Purpose To compare postmortem in situ with ex MRI parameters, including volumetry, diffusion tensor imaging (DTI), and relaxometry for assessing methodology‐induced alterations, which is a crucial prerequisite when performing biomarker validation. Methods whole‐brain scans of five deceased patients amyotrophic lateral sclerosis were performed at 3 T. In conducted within 32 h after death (SD 18 h), brain extraction months formalin fixation. The protocol included MP2RAGE, DTI,...
Diagnosis of Amyotrophic Lateral Sclerosis (ALS) is challenging as initial presentations are various and diagnostic biomarkers lacking. The diagnosis relies on the presence both upper lower motor neuron signs thorough exclusion differential diagnoses, particularly receiving an ALS has major implications for patient. Sjögren's syndrome may mimic peripheral phenotypes should be considered in work-up.A 72-year-old female presented with a mono-neuropathy right leg complaint dry eyes mouth....
Objective: Inflammatory polyradiculomyelitis belongs to a rare group of immune-mediated diseases affecting both the central and peripheral nervous system. We aimed describe an unusual presentation acute with marked spinal cord lesions restricted gray matter. Methods: Thorough examination two case reports including clinical, MRI, serologic, electrophysiologic CSF examinations as well short-term follow-up. Results: present adult patients matter on MRI. The clinical presentation, features...
To evaluate cervical and thoracic spinal cord (SC) gray matter (GM) atrophy its association with disability in patients Amyotrophic Lateral Sclerosis (ALS).
<h3>Objective:</h3> To evaluate the association between spinal cord (SC) gray matter (GM) atrophy and Motor Unit Number Index (MUNIX) in patients with 5q-Spinal Muscular Atrophy (SMA). <h3>Background:</h3> There is an unmet need for valid imaging markers to monitor disease course therapeutic outcome SMA. The novel rAMIRA (radially sampled Averaged Magnetization Inversion Recovery Acquisitions) method enables high in-plane resolution MR-imaging improved contrast of SC GM clinically feasible...
<h3>Objective:</h3> To prospectively evaluate cervical spinal cord (SC) gray matter (GM) area and its association with upper limb function in patients 5q-Spinal Muscular Atrophy (SMA) using rAMIRA (radially sampled Magnetization Inversion Recovery Acquisitions) MR-imaging. <h3>Background:</h3> With the approval of first disease modifying treatments for SMA, there is an increasing need biomarkers that allow easy to perform, reliable, valid course- therapeutic response monitoring. The novel...
Background: Brainstem-mediated functions are impaired in neurodegenerative diseases and aging. Atrophy can be visualized by MRI. This study investigates extrinsic sources of brainstem volume variability, intrinsic anatomical the influence age sex on volumes healthy subjects. We aimed to develop efficient normalization strategies reduce effects anatomic variability volumetry. Methods: Brainstem segmentation was performed from MPRAGE data using our deep-learning-based algorithm MD-GRU. The...