- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Diet and metabolism studies
- Digestive system and related health
- Esophageal Cancer Research and Treatment
- Pelvic floor disorders treatments
- Congenital gastrointestinal and neural anomalies
- Anorectal Disease Treatments and Outcomes
- Pathogenesis and Treatment of Hiccups
- Child Nutrition and Feeding Issues
- Clinical Nutrition and Gastroenterology
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Infant Health and Development
- Diet, Metabolism, and Disease
- Bariatric Surgery and Outcomes
- Diverticular Disease and Complications
- Advanced MRI Techniques and Applications
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Pharmacology and Obesity Treatment
University Hospital of Zurich
2015-2025
University of Zurich
2013-2024
Baylor College of Medicine
2024
University Gastroenterology
2023
University Hospital of Basel
2020-2023
Nottingham University Hospitals NHS Trust
2013-2022
University of Nottingham
2012-2022
ORCID
2022
Swiss Integrative Center for Human Health
2009-2021
Nottingham Biomedical Research Centre
2012-2021
Abstract Background The Chicago Classification ( CC ) of esophageal motility disorders, utilizing an algorithmic scheme to analyze clinical high‐resolution manometry HRM studies, has gained acceptance worldwide. Methods This 2014 update, v3.0, developed by the International Working Group, incorporated extensive experience and interval publications since prior (2011) version. Key Results v3.0 utilizes a hierarchical approach, sequentially prioritizing: (i) disorders esophagogastric junction...
Chronic diarrhoea is a common problem, hence clear guidance on investigations required. This an updated guideline from 2003 for the of chronic commissioned by Clinical Services and Standards Committee British Society Gastroenterology (BSG). document has undergone significant revision in content through input 13 members Guideline Development Group (GDG) representing various institutions. The GRADE system was used to appraise quality evidence grading recommendations.
This manuscript summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for performance, terminology used, and interpretation of anorectal function testing including manometry (focused on high-resolution manometry), rectal sensory test, balloon expulsion test. Based these measurements, a classification system disorders is proposed.Twenty-nine working group members (clinicians/academics in field gastroenterology, coloproctology, gastrointestinal...
Lactose malabsorption is a common condition caused by reduced expression or activity of lactase in the small intestine. In such patients, lactose intolerance characterized abdominal symptoms (e.g. nausea, bloating, and pain) after ingestion dairy products. The genetic basis established several tests for this are available, including genetic, endoscopic, H2-breath tests. contrast, less well understood. Recent studies show that risk depends on dose lactose, expression, intestinal flora,...
Abstract Background Criteria for transient lower esophageal sphincter relaxations ( TLESR s) are well‐defined Dentsleeve manometry. As high‐resolution manometry HRM ) is now the gold standard to assess motility, our aim was propose a consensus definition of s using . Methods Postprandial combined with impedance performed in 10 patients gastroesophageal reflux disease. Transient identification by 17 experts Delphi process. Four investigators then characterized candidates that achieved 100%...
Abstract Background and aims: High‐resolution manometry (HRM) is a recent development in oesophageal measurement; its value the clinical setting remains matter of controversy. (i) We compared accuracy with which bolus transport could be predicted from conventional HRM. (ii) The HRM was assessed series patients endoscopy‐negative dysphagia whom investigations had been non‐diagnostic. Method: Control subjects underwent concurrent video‐fluoroscopy. Ninety‐five records were reviewed using...
Background High-resolution manometry (HRM) with spatiotemporal representation of pressure data is a recent advance in esophageal measurement. At present, normal values are available for 5 mL water swallows the supine position. This study provides reference liquid and solid bolus upright seated positions. Methods A total 23 asymptomatic volunteers (11M : 12F, age 20–56) underwent HRM (Manoscan 360; Sierra Scientific Instruments) 1 cm3 bread Normal primary parameters associated effective...
This study assessed the effects of meal volume (MV) and calorie load (CL) on gastric function. MRI a minimally invasive fiber-optic recording system (FORS) provided simultaneous measurement pressure changes during filling emptying liquid nutrient in physiological conditions. The response to 12 iso-osmolar MV-CL combinations multinutrient drink (MV: 200, 400, 600, 800 ml; CL: 300, 400 kcal) was tested 16 healthy subjects according factorial design. Total (TGV) content (GCV = MV + secretion)...