Nathalie Schwab
A5040348689- Pharmaceutical Practices and Patient Outcomes
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Medication Adherence and Compliance
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Autopsy Techniques and Outcomes
- Atrial Fibrillation Management and Outcomes
- Dietary Effects on Health
- Forensic Anthropology and Bioarchaeology Studies
- Traumatic Ocular and Foreign Body Injuries
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Bone fractures and treatments
- Mycobacterium research and diagnosis
- COVID-19 epidemiological studies
- Cerebrovascular and Carotid Artery Diseases
- Pharmaceutical studies and practices
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- COVID-19 and Mental Health
- Bone health and osteoporosis research
- Circadian rhythm and melatonin
- COVID-19 diagnosis using AI
Universitat Autònoma de Barcelona
2023-2025
University of St. Gallen
2025
University of Bern
2015-2024
University Hospital of Bern
2019-2024
University Hospital of Geneva
2024
University of Lausanne
2021
University of Zurich
2020
University Hospital of Basel
2020
University of Basel
2020
Universitäre Psychiatrische Kliniken Basel
2017
Abstract Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2), which has grown to worldwide pandemic with substantial mortality. Immune mediated damage been proposed as pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles post mortem ( n = 34 tissues from 16 patients) normal lung 9 6 patients). Two distinct...
Abstract Objective To examine the effect of optimising drug treatment on related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting 110 clusters inpatient wards within university based hospitals four European countries (Switzerland, Netherlands, Belgium, Republic Ireland) defined by attending doctors. Participants 2008 (≥70 years) (≥3 chronic conditions) (≥5 drugs used long term). Intervention...
Weight loss is key to controlling the increasing prevalence of metabolic syndrome (MS) and its components, i.e., central obesity, hypertension, prediabetes dyslipidaemia. The goals our study were two-fold. First, we characterised relationships between eating duration, unprocessed processed food consumption health. During 4 weeks observation, 213 adults used a smartphone application record drink consumption, which was annotated for processing levels following NOVA classification. Low low...
To study the effects of a primary care medication review intervention centred around an electronic clinical decision support system (eCDSS) on appropriateness and number prescribing omissions in older adults with multimorbidity polypharmacy compared discussion about line usual care.Cluster randomised trial.Swiss care, between December 2018 February 2021.Eligible patients were ≥65 years age three or more chronic conditions five long term medications.The to optimise pharmacotherapy eCDSS was...
Introduction Multimorbidity and polypharmacy are important risk factors for drug-related hospital admissions (DRAs). DRAs often linked to prescribing problems (overprescribing underprescribing), as well non-adherence with drug regimens different reasons. In this trial, we aim assess whether a structured medication review compared standard care can reduce in multimorbid older patients polypharmacy. Methods analysis OPtimising thERapy prevent Avoidable Multimorbid people is European...
Abstract While coronavirus disease 2019 (COVID‐19) primarily affects the respiratory tract, pathophysiological changes of cardiovascular system remain to be elucidated. We performed a retrospective cardiopathological analysis heart and vasculature from 23 autopsies COVID‐19 patients, comparing findings with control tissue. Myocardium patients was categorised into severe acute syndrome 2 (SARS‐CoV‐2) positive ( n = 14) or negative 9) based on presence viral RNA as determined by reverse...
Objectives: To describe the rationale, organization, and procedures of Corona Immunitas Digital Follow-Up (CI-DFU) eCohort to characterize participants at baseline. Methods: Participants Immunitas, a population-based nationwide SARS-CoV-2 seroprevalence study in Switzerland, were invited join CI-DFU 11 centres. Weekly online questonnaires cover health status changes, prevention measures adherence, social impacts. Monthly questionnaires additional contact tracing apps use, vaccination vaccine...
Abstract Background Several approaches to medication optimisation by identifying drug-related problems in older people have been described. Although some interventions shown reductions (DRPs), evidence supporting the effectiveness of reviews on clinical and economic outcomes is lacking. Application STOPP/START (version 2) explicit screening tool for inappropriate prescribing has decreased significantly reduced adverse drug reactions (ADRs) associated healthcare costs patients with...
Purpose The purpose of this retrospective study was to correlate CT patterns fatal cases coronavirus disease 2019 (COVID-19) with postmortem pathology observations. Materials and Methods included 70 lung lobes 14 patients who died reverse-transcription polymerase chain reaction–confirmed COVID-19. All underwent antemortem autopsy between March 9 April 30, 2020. Board-certified radiologists pathologists performed lobewise correlations pulmonary In a consensus reading, 267 radiologic 257...
Abstract Objectives Recruiting general practitioners (GPs) and their multimorbid older patients for trials is challenging multiple reasons (e.g., high workload, limited mobility). The comparability of study participants important interpreting findings. This manuscript describes the baseline characteristics GPs participating in ‘Optimizing PharmacoTherapy adults In primary CAre’ (OPTICA) trial, a optimization pharmacotherapy adults. overall aim this was to determine if OPTICA trial are...
Abstract Skeletal trauma assessment is an important task of forensic anthropologists and pathologists. This applies in particular to badly preserved bodies where the soft tissue cannot provide evidence. Yet, interpretation ballistic long bone can be difficult due little conclusive data. Thus, this study explored variability diaphyseal fracture patterns dependent on bullet’s angle point impact. 20 femurs from body donors were embedded Clear Ballistics Gel ® divided into 4 experimental groups:...
Coronavirus disease 2019 (COVID-19) mortality can be estimated based on reliable data. Variable testing procedures and heterogeneous course suggest that a substantial number of COVID-19 deaths is undetected. To address this question, we screened an unselected autopsy cohort for the presence SARS-CoV-2 panel common respiratory pathogens. Lung tissues from 62 consecutive autopsies, conducted during first second pandemic waves in Switzerland, were analyzed bacterial, viral fungal pathogens...
Abstract Weight loss is key to control the increasing prevalence of metabolic syndrome (MS) and its components, i.e. central obesity, hypertension, prediabetes, dyslipidaemia. We characterised relationships between eating duration, unprocessed processed food consumption, health. During 4 weeks observation, 213 adults used a smartphone application record drink which was annotated for processing levels following NOVA classification. Consumption items showed highest number significant...
Sustained forms of atrial fibrillation (AF) may be associated with a higher risk adverse outcomes, but few if any long-term studies took into account changes AF type and co-morbidities over time. We prospectively followed 3843 patients collected information on during yearly follow-ups. The primary outcome was composite stroke or systemic embolism (SE). Secondary outcomes included myocardial infarction, hospitalization for congestive heart failure (CHF), bleeding all-cause mortality....
Introduction Multimorbidity and polypharmacy are major risk factors for potentially inappropriate prescribing (eg, overprescribing underprescribing), systematic medication reviews complex time consuming. In this trial, the investigators aim to determine if a software-based review improves appropriateness more than standard care in older, multimorbid patients with polypharmacy. Methods analysis Optimising PharmacoTherapy elderly primary CAre is cluster randomised controlled trial that will...
Forensic anthropologists play a key role in skeletal trauma analysis and commonly use macroscopic features to distinguish between types. However, this approach can be challenging, particularly cases of highly comminuted or incompletely recovered fractures. Histological microscopic fracture characteristics fractured bones may thus help provide additional information on type bone biomechanics general. This study analysed the extent microcrack damage osteons long with blunt force (BFT) gunshot...
Abstract Whereas gunshot injuries in human craniums have been well studied, reliable data on fracture patterns ballistic long bone trauma remains scarce. Further information useful for forensic interpretation and reconstruction may be retrieved from experimentally produced fractures. In order to avoid the use of specimens experimental research, it is great interest determine whether alternative models can reproduce bones. To address this question, we shot seven healthy adult femurs humeri...
In forensic anthropology, the differential diagnosis between peri- and postmortem bone fractures is mainly based on macroscopic criteria. contrast, studies focusing histology are very scarce. a recent publication, we showed that (perimortem) in fresh human bones exhibit different osteonal microcracking pattern than (postmortem) damage dry bones. current work, explored whether this distinctive of vitality fractures. To end, compared number, length structural distribution microcracks vital...
Abstract Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2), which has grown to worldwide pandemic with substantial mortality. Immune mediated damage been proposed as pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Therefore we conducted transcriptomic, histologic and cellular profiling post mortem (n=34 tissues from 16 patients) normal lung (n=9 6 patients). Two distinct...
The association of blood pressure (BP) and hypertension with the presence different types brain lesions in patients atrial fibrillation is unclear. BP values were obtained a multicenter cohort fibrillation. Systolic diastolic was categorized predefined groups. All underwent magnetic resonance imaging neurocognitive testing. Brain classified as large noncortical or cortical infarcts, small microbleeds, white matter lesions. White graded according to Fazekas scale. Overall, 1738 enrolled this...