A5077404628- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Histiocytic Disorders and Treatments
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Esophagitis
- Mycobacterium research and diagnosis
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- COVID-19 Clinical Research Studies
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Radiomics and Machine Learning in Medical Imaging
- Chronic Lymphocytic Leukemia Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
University of Bern
2011-2024
Kantonsspital Baselland
2014-2024
Psychiatry Baselland
2007-2023
Theological Seminary Bienenberg
2001-2021
Kantonsspital Baselland Standort Bruderholz
2005-2021
Harvard University
2021
University Hospital of Lausanne
2021
Beth Israel Deaconess Medical Center
2021
University of Zurich
1999-2020
University of Basel
1994-2020
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly evolved into a sweeping pandemic. Its major manifestation is in the tract, and general extent of organ involvement microscopic changes lungs remain insufficiently characterised. Autopsies are essential to elucidate COVID-19-associated alterations.This article reports autopsy findings 21 COVID-19 patients hospitalised at University Hospital Basel Cantonal Baselland,...
The histologic examination of endoscopic biopsies or resection specimens remains a key step in the work-up affected inflammatory bowel disease (IBD) patients and can be used for diagnosis differential diagnosis, particularly differentiation UC from CD other non-IBD related colitides. introduction new treatment strategies interfering with patients' immune system may result mucosal healing, making pathologists aware impact upon diagnostic features. European Crohn's Colitis Organisation (ECCO)...
Abstract Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2), which has grown to worldwide pandemic with substantial mortality. Immune mediated damage been proposed as pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles post mortem ( n = 34 tissues from 16 patients) normal lung 9 6 patients). Two distinct...
<h3>Background</h3> Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) have been recently approved for treatment of patients with metastatic melanoma non-small lung cancer (NSCLC). Despite important clinical benefits, these therapies are associated a diverse spectrum immune-related adverse events (irAEs) that typically transient, but occasionally severe or even fatal. <h3>Case presentation</h3> This autopsy case...
SARS-CoV-2 infection (COVID-19 disease) can induce systemic vascular involvement contributing to morbidity and mortality. targets epithelial endothelial cells through the ACE2 receptor. The anatomical of coronary tree is not explored yet.Cardiac autopsy tissue entire (main arteries, epicardial arterioles/venules, capillaries) nerves were analyzed in COVID-19 patients (n = 6). All regions immunohistochemically tested for ACE2, TMPRSS2, CD147, CD45, CD3, CD4, CD8, CD68 IL-6. negative with...
Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture erosion, both causes of thrombosis events. We tested the hypothesis that inflammation angiogenic increased throughout tree in vulnerable patients, ie, patients who suffered from events, compared with never complications atherosclerosis.In a postmortem study, we...
Human herpesvirus 8 (HHV-8) has been detected in all forms of Kaposi's sarcoma, including transplantation-associated sarcoma. To investigate the possibility transmission HHV-8 through allografts, we measured seroprevalence before and after renal transplantation.
Abstract Major etiologic factors associated with human hepatocellular carcinomas (HCCs) include infection hepatitis C (HCV) and B virus (HBV), excess alcohol intake aflatoxin 1 exposure. While the G→T p53 mutation at codon 249 has been identified as a genetic hallmark of HCC caused by , profile other appears to be less distinctive. In our study, we screened HCCs resulting from HCV (51 cases), HBV (26 cases) or (23 for alterations in genes involved RB1 pathway (p16 INK4a p15 INK4b RB1, CDK4...
<h3>Objective</h3> Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing permeability in colon mice. <h3>Design</h3> Expression IL-33 was determined by qRT-PCR, ELISA, immunohistochemistry western-blot analysis. Wild-type <i>St2</i><sup>−/−</sup> mice were used experiments two experimental...
The role of cytomegalovirus (CMV)-specific cytotoxic T lymphocytes (CTLs) and helper cells (Th) in controlling CMV infection, as detected by antigenemia assay polymerase chain reaction (PCR) blood leukocytes, disease was investigated 20 renal transplant recipients. Within 3 months after transplant, CMV-specific CTL Th responses were demonstrable 11 (55%) 15 (75%) patients, respectively; infection PCR 19 (95%) patients each. During the month first detection, there an inverse correlation...
The status of the gene encoding human EGF-like receptor 2 (HER2) is an important prognostic and predictive marker in breast cancer. Only cancers with HER2 amplification respond to targeted therapy trastuzumab. It controversial what degree primary tumour representative distant metastases terms status. Discrepancies between tumours have been described, but their reasons remain unclear. Here, we compared on cytological specimens result from carcinomas, explored prevalence for discrepant...
The objective of this study was to evaluate the diagnostic value chromosomal analysis by fluorescence in situ hybridization (FISH) for predicting recurrence urothelial carcinoma (UC) after transurethral resection. One hundred and thirty-eight patients (median age 68.5 years) with a history UC were eligible prospective study. FISH applied cytospin specimens prepared from bladder washings taken during negative control cystoscopy. multi-target test UroVysion (Abbott/Vysis) containing probes...
Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood. Interleukin (IL)-33 signaling plays role in inflammation, yet its contribution to pathogenesis of CRC unknown.Using immunohistochemistry on 713 resected human specimens, we show here IL-33 receptor ST2 are expressed low-grade early-stage CRCs, lesser extent higher-grade more...
Aims Immune checkpoint inhibitors have become a successful treatment in metastatic melanoma. The high response rates subset of patients suggest that sensitive companion diagnostic test is required. predictive value programmed death ligand 1 ( PD ‐L1) staining melanoma has been questioned due to inconsistent correlation with clinical outcome. Whether this irrelevance ‐L1 expression or inaccurate assessment techniques remains unclear. aim study was develop standardised digital protocol for the...
We report the case of a 58-year-old renal transplant patient who developed oral hairy leukoplakia. Examination for HIV-1 and HIV-2 infection was negative. Biopsy lateral tongue showed ballooned prickle cells electron microscopy revealed herpes-type viruses. In situ hybridization examinations with Southern blot technique yielded Epstein-Barr virus. Serology virus reactive. Immunological investigation marked decrease T-helper T-suppressor as result immunosuppressive regimen. Oral leukoplakia...