A5043803342- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Coronary Artery Anomalies
- Neurological Disorders and Treatments
- Burn Injury Management and Outcomes
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Pulmonary Hypertension Research and Treatments
- Antibiotic Use and Resistance
- Tracheal and airway disorders
- Pharmaceutical Practices and Patient Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Congenital Diaphragmatic Hernia Studies
- Renal and Vascular Pathologies
- Kawasaki Disease and Coronary Complications
- Cardiac Arrest and Resuscitation
- Cardiovascular and Diving-Related Complications
- Health Systems, Economic Evaluations, Quality of Life
- Antibiotic Resistance in Bacteria
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
Centre Hospitalier Universitaire Sainte-Justine
1992-2025
Université de Montréal
1992-2025
University Hospital of Lausanne
2014-2024
University of Lausanne
2014-2022
UCLouvain
2020-2021
University of Geneva
2014-2018
Hôpital Européen
2017
Hôpital Européen Georges-Pompidou
2017
Assistance Publique – Hôpitaux de Paris
2017
Canadian Paediatric Society
2017
Abstract Objective To examine the effect of optimising drug treatment on related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting 110 clusters inpatient wards within university based hospitals four European countries (Switzerland, Netherlands, Belgium, Republic Ireland) defined by attending doctors. Participants 2008 (≥70 years) (≥3 chronic conditions) (≥5 drugs used long term). Intervention...
Abstract Background Individuals with Friedreich ataxia (FRDA) can find it difficult to access specialized clinical care. To facilitate best practice in delivering healthcare for FRDA, management guidelines (CMGs) were developed 2014. However, the lack of high-certainty evidence and inadequacy accepted metrics measure health status continues present challenges FRDA other rare diseases. overcome these challenges, Grading Recommendations Assessment Evaluation (GRADE) framework diseases by...
As pharmacokinetics after burn trauma are difficult to predict, we conducted a 3-year prospective, monocentric, randomized, controlled trial determine the extent of under- and overdosing antibiotics further evaluate impact systematic therapeutic drug monitoring (TDM) with same-day real-time dose adaptation reach maintain antibiotic concentrations within range. Forty-five consecutive patients treated were prospectively screened. Forty fulfilled inclusion criteria; one patient refused...
The investigation of sudden death is challenging, but utmost importance to guide screening in potentially at-risk relatives. We present a case 14-year-old boy Central Asian ancestry with palpitations and recent his sister. Autopsy revealed ischemic injury uncertain etiology. Family evaluation mild QT prolongation relatives cosegregating novel CACNA1C variant (Gly856Asp). Functional vitro analyses show slower inactivation kinetics (gain function) as shown the long syndrome type 8. highlights...
Hybrid procedures that combine surgical and interventional techniques are increasingly utilized in patients with congenital heart disease. We performed a novel hybrid intervention involving transcatheter ablation via sternotomy approach atriotomy incision. A recalcitrant accessory pathway was successfully ablated patient hemodynamically unstable supraventricular tachycardia an extracadiac Fontan for hypoplastic left syndrome.
Hemodiafiltration is currently one of the most effective techniques extra-renal purification but results in an increase albumin loss dialysate. We aimed to determine factors associated with during post-dilution hemodiafiltration, compare "automatic" mode infusate flow control versus a "manual" control, and assess potential nutritional impact.This prospective observational study included all hemodialysis patients our institution who underwent hemodiafiltration 3 times week on Fresenius 5008...
The authors describe an invasive Aspergillus fumigatus deep-burn wound infection in a severely burned patient that was successfully treated with combination of topical terbinafine and systemic voriconazole antifungal therapy. To our knowledge, this is the first case report describing effective control using combination.
Pulse oximetry screening is safe, noninvasive, easy to perform and proven enhance detection of critical congenital heart disease in newborns. However, this test has yet be adopted as routine practice Canada. The present point highlights essential details recommendations for screening, which research shown highly specific, with low false-positive rates. Optimal should include prenatal ultrasound, physical examination pulse screening. Screening performed between 24 hours 36 postbirth, using...
The objective of this study was to investigate the population pharmacokinetics (PK) amoxicillin in ICU burn patients and optimal dosage regimens. This a prospective involving 21 consecutive receiving amoxicillin.
Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports small-colony variant (SCV) emergence P. aeruginosa, taken from patient under aminoglycosides for persistent infection. confirm causative role single ispA mutation SCV and increased aminoglycoside resistance. IspA involved synthesis ubiquinone, providing possible link between electron transport formation aeruginosa.