A5067477787- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Hemophilia Treatment and Research
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Chronic Disease Management Strategies
- Diabetes Management and Research
- Medication Adherence and Compliance
- Blood Coagulation and Thrombosis Mechanisms
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Frailty in Older Adults
- Intensive Care Unit Cognitive Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmacy and Medical Practices
- Schizophrenia research and treatment
- Sleep and related disorders
- Dementia and Cognitive Impairment Research
- Cardiovascular Function and Risk Factors
- Voice and Speech Disorders
- Platelet Disorders and Treatments
- Health, Medicine and Society
- Stroke Rehabilitation and Recovery
- Childhood Cancer Survivors' Quality of Life
- Diabetes, Cardiovascular Risks, and Lipoproteins
UCLouvain
2016-2025
Institut Scientifique de Santé Publique
2012-2025
Solvay (Belgium)
2018-2023
KU Leuven
2016-2019
Cliniques Universitaires Saint-Luc
2011-2018
University of Liège
2010
The long-term mortality in adults treated with recombinant GH during childhood has been poorly investigated. Recently released data from the French part of European Union Safety and Appropriateness treatments Europe (EU SAGhE) study have raised concerns on safety treatment.To report preliminary vital status causes death patients isolated deficiency or idiopathic short stature born small for gestational age childhood, Belgium, Netherlands, Sweden.Data were retrieved national registries...
The aim of this paper was to describe the time trends in prevalence multimorbidity and polypharmacy Flanders (Belgium) between 2000 2015, while controlling for age sex.Data were available from Intego, a Flemish-Belgian general practice-based morbidity registration network. practice population 2015 used as denominator, representing mean 159,946 people per year. Age gender-standardised rates total subgroups. Joinpoint regression analyses analyse breaks trends, entire well specific sex...
Hospital staff are a priority target group in the European COVID-19 vaccination strategy. Measuring extent of hesitancy and understanding reasons behind it essential to be able tailor effective communication campaigns. Using Health Belief Model (HBM) as theoretical framework, survey was conducted among members Belgian three-site hospital center between 6 20 January 2021. Multivariable logistic ordinal regression performed assess determinants attitude towards vaccination. Reasons for against...
Abstract ( N = 351) Background Drug-drug interactions (DDIs) are highly prevalent in older patients but little is known about prevalence of DDIs over time. Our main objective was to assess changes the and characteristics drug-drug during a one-year period after hospital admission people, associated risk factors. Methods We conducted sub-study European OPERAM trial (OPtimising thERapy prevent Avoidable admissions Multimorbid people), which assessed effects structured medication review...
Objectives To assess the prevalence and incidence of heart failure (HF) stages A to C/D their evolution over a 16-year period. Additionally, trends in comorbidities cardiovascular (CV) treatment patients with HF were studied same Design Registry-based study. Setting Primary care, Flanders, Belgium. Participants Data obtained from Intego, morbidity registration network which 111 general practitioners 48 practices collaborate. In study period between 2000 2015, data 165 796 unique aged 45...
Due to the global coronavirus disease 2019 pandemic, high risk of cross-contamination and overload hospital facilities have resulted in a real urgency for restricting dental emergency patient flow. In this context, objectives current work were 1) measure ability triage-based management strategy limit admission 2) evaluate success rate both on-site remote regarding symptom relief pain control over 1-mo period. We included all patients contacting medicine department an consultation during...
Abstract Background Diabetes overtreatment is a frequent and severe issue in multimorbid older patients with type 2 diabetes (T2D). Objective This study aimed at assessing the association between 1-year functional decline, hospitalisation mortality inpatients multimorbidity polypharmacy. Methods Ancillary of European multicentre OPERAM project on aged ≥70 years T2D glucose-lowering treatment (GLT). was defined according to 2019 Endocrine Society guideline using HbA1c target range...
Background. Coronary artery calcification (CAC) independently predicts cardiovascular events (CVE) in the general population. Whether this applies to renal transplant recipients (RTR) is unknown. This prospective study assessed prognostic impact of CAC on CVE RTR.
To date, there has been no comprehensive study on the association between atrial fibrillation (AF) and multimorbidity. The present investigated epidemiology of AF multimorbidity onset AF. In addition, correlation use anticoagulants risk cerebrovascular events considering was explored in patients. Intego is a primary care registry network Belgium. A case–control performed using data from 10-year time interval (2002 to 2011). All patients aged 60 years older 2002 who had developed new 2011...
Background An increasing number of older patients are hospitalised. Prognostic uncertainty causes hospital doctors to be reluctant make the switch from cure care. The Supportive and Palliative Care Indicators Tool (SPICT) has not been validated for prognostication in an hospitalised population. Aim To validate SPICT as a prognostic tool risk dying within one year patients. Design Prospective multicentre study. Premorbid 1-year survival time were assessed. Setting/participants Patients 75...
In Belgium, linezolid is indicated for pneumonia and skin soft tissue infections, but more broadly used, due to its oral bioavailability activity against multiresistant organisms. This could increase the risk of adverse drug reactions (ADR), notably hematological disorders (anemia, thrombocytopenia), neuropathy, or lactic acidosis. We analyzed clinical use in relationship with occurrence ADR Belgian hospitals highlighted factors associated development thrombocytopenia. A retrospective...
Since 1981, the number of factor VIII units to infuse into patients with hemophilia A in order achieve adequate circulating levels has been calculated using formula: [body weight(kg)×desired increase(%)]/2, assuming a recovery value 2 for all patients. This study's aim was evaluate impact several morphometric parameters and various coagulation concentrates on recovery. The analysis included 201 adults (>18 years age) who were carefully selected from eight pharmacokinetic clinical trials...
Ageing has become a worldwide reality and presents new challenges for the health-care system. Research shown that potentially inappropriate prescribing, both medications prescribing omissions, is highly prevalent in older people, especially nursing home setting. The presence of medications/potentially omissions associated with adverse drug events, hospitalisations, mortality costs. Collaborative approach to Optimise MEdication use Older people Nursing homes (COME-ON) study aims evaluate...
Haemophilia is a rare hereditary haemorrhagic disease that requires regular intravenous injections of clotting factor (CF) concentrates. This study sought to estimate the health and economic burden haemophilia in Belgium. first its type be conducted, reflects Belgian authorities' growing interest for as part their priority planning chronic diseases.A probabilistic model was developed order lifetime 2011 birth-year cohort. The initially expressed terms disability-adjusted life years (DALYs),...
Rare diseases are often serious, chronic and life-threatening. The European Union (EU) definition of a rare disease is one that affects fewer than 5 in 10 000 people. (1) At present, more 6000 known; around 80% them genetic disorders half occur during childhood. Grouped together, affect 6-8% (or about 30 million people) out the 508 population EU countries. (2) This roughly equals estimated prevalence diabetes World Health Organization Region, which 2013 was 6.8% 658.7 adults 20-79 year age...
<h3>Importance</h3> The most appropriate therapy for older adults with multimorbidity may depend on life expectancy (ie, mortality risk), and several scores have been developed to predict 1-year risk. However, often, these risk not externally validated in large sample sizes, a head-to-head comparison prospective contemporary cohort is lacking. <h3>Objective</h3> To prospectively compare the performance of 6 predicting hospitalized multimorbidity. <h3>Design, Setting, Participants</h3> This...
ABSTRACT Background Complex regional pain syndrome (CRPS) is a debilitating condition characterised by significant heterogeneity. Early diagnosis critical, but limited data exists on the condition's early stages. This study aimed to characterise (very) CRPS patients and explore potential subgroups enhance understanding of its mechanisms. Methods A total 113 were recruited, with 89 undergoing physical assessments. Data included demographic information, work‐related factors, history clinical...