A5053382062- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Pituitary Gland Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Pharmaceutical Practices and Patient Outcomes
- Bone health and osteoporosis research
- SARS-CoV-2 and COVID-19 Research
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin D Research Studies
- COVID-19 Clinical Research Studies
- Cardiac Arrhythmias and Treatments
- Chronic Disease Management Strategies
- Cardiac Imaging and Diagnostics
- Pneumonia and Respiratory Infections
- Venous Thromboembolism Diagnosis and Management
- Musculoskeletal pain and rehabilitation
- Neuroscience of respiration and sleep
- Acute Ischemic Stroke Management
- Healthcare cost, quality, practices
- Cardiovascular and exercise physiology
University Hospital of Bern
2016-2025
University of Bern
2016-2025
Public Health – Seattle & King County
2025
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
University Medical Center Utrecht
2023
Utrecht University
2023
Cliniques Universitaires Saint-Luc
2023
UCLouvain
2023
University of British Columbia
2023
The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed determine whether provided clinical benefits in older persons with this condition.
Abstract Objective To examine the effect of optimising drug treatment on related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting 110 clusters inpatient wards within university based hospitals four European countries (Switzerland, Netherlands, Belgium, Republic Ireland) defined by attending doctors. Participants 2008 (≥70 years) (≥3 chronic conditions) (≥5 drugs used long term). Intervention...
It is unclear whether levothyroxine treatment provides clinically important benefits in adults aged 80 years and older with subclinical hypothyroidism.To determine the association of for hypothyroidism thyroid-related quality life older.Prospectively planned combined analysis data involving community-dwelling hypothyroidism. Data from a randomized clinical trial were subgroup participants second trial. The trials conducted between April 2013 May 2018. Final follow-up was 4, 2018.Participants...
Background Risk assessment is the cornerstone for atherosclerotic cardiovascular disease ( ASCVD ) treatment decisions. The Pooled Cohort Equations PCE have not been validated in disaggregated Asian or Hispanic populations, who heterogeneous risk and outcomes. Methods Results We used electronic health record data from adults aged 40 to 79 years a community-based, outpatient healthcare system northern California between January 1, 2006 December 31, 2015, without on statins. examined...
E-values are a recently introduced approach to evaluate confounding in observational studies. We aimed empirically assess the current use of published literature.We conducted systematic literature search for all publications, up till end 2018, which cited at least one two inceptive E-value papers and presented original data. For these case publications we identified control matched by journal issue, where authors had not calculated E-values.In total, 87 516 E-values. Of papers, 14 concluded...
The E-value was recently introduced on the basis of earlier work as "the minimum strength association…that an unmeasured confounder would need to have with both treatment and outcome fully explain away a specific treatment–outcome association, conditional measured covariates." E-values been proposed for wide application in observational studies evaluating causality. However, they limitations are prone misinterpretation. monotonic, almost linear relationship effect estimates thus offer no...
Objectives To estimate and compare the prevalence type of potentially inappropriate prescribing (PIP) potential omissions (PPOs) among community-dwelling older adults (≥65 years) enrolled to a clinical trial in three European countries. Design A secondary analysis Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset. Participants subset 48/80 PIP 22/34 PPOs indicators from Screening Tool Older Persons Prescriptions/Screening Alert doctors Right Treatment (STOPP/START) V2...
Serum neurofilament light chain (sNfL) is increasingly used as a neuroaxonal injury biomarker in the elderly. Besides age, little known about how other physiological factors like renal function and body mass index (BMI) alter its levels. Here, we investigated association of estimated glomerular filtration rate (eGFR) BMI with sNfL large sample elderly patients atrial fibrillation (AF).This cross-sectional analysis from Swiss-AF Cohort (NCT02105844). We measured using an ultrasensitive...
Background Patients with atrial fibrillation (AF) face an increased risk of death and major adverse cardiovascular events (MACE). We aimed to assess the predictive value novel atrial-specific biomarker BMP10 (bone morphogenetic protein 10) for MACE in patients AF comparison NT-proBNP (N-terminal prohormone B-type natriuretic peptide). Methods Results were measured enrolled Swiss-AF (Swiss Atrial Fibrillation Study), a prospective multicenter cohort study. A total 2219 included (median...
<b><i>Background:</i></b> Subclinical hypothyroidism has been associated with depressive symptoms in cross-sectional studies, but prospective data and on subclinical hyperthyroidism are scarce. <b><i>Methods:</i></b> In the Leiden substudy of Prospective Study Pravastatin Elderly at Risk (PROSPER), thyroid-stimulating hormone free T<sub>4</sub> levels were measured baseline repeated after 6 months adults aged 70-82 years preexisting...
Subclinical hypothyroidism has been associated with heart failure, but only small trials assessed whether treatment levothyroxine an impact on cardiac function.In a randomized, double-blind, placebo-controlled, trial nested within the TRUST trial, Swiss participants ages ≥65 years subclinical (thyroid-stimulating hormone [TSH] 4.60-19.99 mIU/L; free thyroxine level reference range) were randomized to (starting dose of 50 µg daily) achieve TSH normalization or placebo. The primary outcomes...
Background: Patients with heart failure (HF) discharged from the hospital are at high risk for death and rehospitalization. Transitional care service interventions attempt to mitigate these risks. Objective: To assess cost-effectiveness of 3 types postdischarge HF transitional services standard care. Design: Decision analytic microsimulation model. Data Sources: Randomized controlled trials, clinical registries, cohort studies, Centers Disease Control Prevention life tables, Medicare &...
Subclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4). Evidence lacking about the effect of thyroid treatment. We describe protocol large randomised controlled trial (RCT) Levothyroxine treatment for SCH. Participants are community-dwelling subjects aged ≥65 years SCH, diagnosed by TSH levels (≥4.6 and ≤19.9 mU/L) on minimum two measures ≥ three months apart, fT4...
Abstract Context Subclinical hypothyroidism (SHypo) has been associated with atherosclerosis, but no conclusive clinical trials assessing the levothyroxine impact on carotid atherosclerosis exist. Objective To assess of treatment SHypo atherosclerosis. Design and Setting Randomized, double-blind, placebo-controlled trial nested within Thyroid Hormone Replacement for Hypothyroidism trial. Participants aged ≥65 years [thyroid-stimulating hormone (TSH), 4.60 to 19.99 mIU/L; free thyroxine level...