A5003162453- Dietary Effects on Health
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Genetics, Aging, and Longevity in Model Organisms
- Nutritional Studies and Diet
- Sleep and related disorders
- Diet, Metabolism, and Disease
- Eating Disorders and Behaviors
- Spaceflight effects on biology
- Nutrition and Health in Aging
- Mobile Health and mHealth Applications
- Antioxidants, Aging, Portulaca oleracea
- Neurobiology and Insect Physiology Research
- Sleep and Work-Related Fatigue
- Cardiovascular Health and Risk Factors
- Photoreceptor and optogenetics research
- Psychological and Temporal Perspectives Research
- High Altitude and Hypoxia
- Physical Activity and Health
- Neuroendocrine regulation and behavior
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Pharmacology and Obesity Treatment
- Light effects on plants
- Cancer survivorship and care
Salk Institute for Biological Studies
2016-2025
Institute for Biological Sciences
2024-2025
University of Massachusetts Amherst
2015-2024
University of California, San Diego
2019-2024
La Jolla Alcohol Research
2019-2020
Objective This study aimed to assess the effects of 9‐hour time‐restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes. Methods Fifteen (age 55 ± 3 years, BMI 33.9 0.8 kg/m ) wore a continuous monitor 7 days baseline assessment and during two 7‐day TRF conditions. Participants were randomized TRFe (8 am 5 pm TRFd (12 9 ), separated by 2‐week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, gastrointestinal...
In contrast to intentionally restricting energy intake, the eating window may be an option for treating obesity. By comparing time-restricted (TRE) with unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.Participants (17 women 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m2 ) a prolonged (15.4 [0.9] hours) were randomized (n = 11: 8-hour window, within window) versus non-TRE 9: eating) 12...
Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic...
Over a quarter of the workforce in industrialized countries does shift work, which increases risk for cardiometabolic disease. Yet workers are often excluded from lifestyle intervention studies to reduce this risk. In randomized control trial with 137 firefighters who work 24-h shifts (23-59 years old, 9% female), 12 weeks 10-h time-restricted eating (TRE) was feasible, TRE participants decreasing their window (baseline, mean 14.13 h, 95% CI 13.78-14.47 h; intervention, 11.13 10.73-11.54 p =...
Although fasting is increasingly applied for disease prevention and treatment, consensus on terminology lacking. Using Delphi methodology, an international, multidisciplinary panel of researchers clinicians standardized definitions various approaches in humans. Five online surveys a live conference were conducted with 38 experts, 25 whom completed all 5 surveys. Consensus was achieved the following terms: "fasting" (voluntary abstinence from some or foods beverages), "modified fasting"...
Weight loss is key to controlling the increasing prevalence of metabolic syndrome (MS) and its components, i.e., central obesity, hypertension, prediabetes dyslipidaemia. The goals our study were two-fold. First, we characterised relationships between eating duration, unprocessed processed food consumption health. During 4 weeks observation, 213 adults used a smartphone application record drink consumption, which was annotated for processing levels following NOVA classification. Low low...
Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted (UE) on weight, body composition, intake, glycemic measures, metabolic flexibility. In this 12-week randomized-controlled trial, we measured (primary outcome), composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), intake (24-h recall), flexibility (indirect calorimetry during hyperinsulinemic-euglycemic...
Abstract Objective Time‐restricted eating (TRE) restores circadian rhythms in mice, but the evidence to support this humans is limited. The objective of study was investigate effects TRE on 24‐hour profiles plasma metabolites, glucoregulatory hormones, and subcutaneous adipose tissue (SAT) transcriptome humans. Methods Men ( n = 15, age 63 [4] years, BMI 30.5 [2.4] kg/m 2 ) were recruited. A 35‐hour metabolic ward stay conducted at baseline after 8 weeks 10‐hour TRE. Assessment included...
Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.
The goal of this study was to test the feasibility time restricted eating (TRE) in adults with overweight and obesity. Participants (n = 50) logged all occasions (>0 kcal) for a 2-week run-in period using smartphone application. duration ≥14 h enrolled an open label, non-randomized, prospective 90-day TRE intervention, self-selected reduced window 10 h. No dietary counseling provided. Changes anthropometrics, patterns adherence after were analyzed t-tests or Wilcoxon Rank-Sum Test. mean...
We aim to describe temporal eating patterns in a population of adults with overweight or obesity. In this cross-sectional analysis, data were combined from two separate pilot studies during which participants entered the timing all occasions (>0 kcals) for 10-14 days. Data aggregated determine total occasions, local time first and last window, midpoint, within-person variability patterns. Eating compared between sexes, as well weekday weekends. Participants (n = 85) had median age 56 ± 19...
Time-restricted eating (TRE) reduces weight in humans, but its effects on quality of life have not been well characterized. By performing a secondary analysis randomized clinical trial, we examined the TRE (12-week intervention, 8 h window) vs. non-TRE (unrestricted eating) (QoL) measures. Twenty subjects with overweight and prolonged window (mean (SD): 15.4 (0.9)) were to either 12 weeks (8 window: (n = 11)) or 9). QoL data collected 36-item Short Form Survey (SF-36) pre- post-intervention....
Background Time restricted eating (TRE), limiting to a specific daily window, is novel dietary intervention, but the mechanisms by which TRE results in weight loss remain unclear. The goal of current study was examine changes patterns, sleep, and late-night eating, associations with health outcomes secondary analysis 12-week self-selected intervention. Methods Twenty participants 18–65 years BMI ≥25 kg/m2 completed trial. Participants randomized ( n = 11) were instructed eat during 8-h while...
This observational pilot study examined the association between diet, meal pattern and glucose over a 2-week period under free-living conditions in 26 adults with dysglycemia (D-GLYC) 14 normoglycemia (N-GLYC). We hypothesized that prolonged eating window late occasions (EOs), along higher dietary carbohydrate intake, would result levels variability (GV). General linear models were run timing time-stamped photographs real time, diet composition by recalls, their (SD), as predictors variables...
Metabolic syndrome (MetS) and a prolonged daily eating window (EW) are associated with circadian rhythm disruption increased cardiometabolic risk. Misalignment between timing system rhythms of food intake adversely impacts metabolic regulatory mechanisms cardiovascular function. Restricting the EW by imposing an eating–fasting cycle through time-restricted (TRE) can restore robust rhythms, support cellular metabolism, improve health. The aim this study was to assess feasibility 12-week TRE...
Post-prandial glucose response (PPGR) is a risk factor for cardiovascular disease. Meal carbohydrate content an important predictor of PPGR, but dietary interventions to mitigate PPGR are not always successful. A personalized approach, considering behaviour and habitual pattern excursions assessed by continuous monitor (CGM), may be more effective.