A5075094490- Retinal and Optic Conditions
- Vasculitis and related conditions
- Traumatic Ocular and Foreign Body Injuries
- Ocular Diseases and Behçet’s Syndrome
- Acute Ischemic Stroke Management
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Hereditary Neurological Disorders
- Neurological diseases and metabolism
- Facial Trauma and Fracture Management
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and genetic disorders
- Nerve injury and regeneration
- Cerebrovascular and Carotid Artery Diseases
- Neurogenetic and Muscular Disorders Research
- Melanoma and MAPK Pathways
- Neurological Complications and Syndromes
- Hemoglobinopathies and Related Disorders
- Cell Adhesion Molecules Research
- Venous Thromboembolism Diagnosis and Management
- Peripheral Neuropathies and Disorders
- Herpesvirus Infections and Treatments
- Wnt/β-catenin signaling in development and cancer
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
Ruhr University Bochum
2019-2025
Universitätsklinikum Knappschaftskrankenhaus Bochum
2018-2025
Hillel Yaffe Medical Center
2024
Sheba Medical Center
2024
Tel Aviv University
2024
Rabin Medical Center
2024
Technion – Israel Institute of Technology
2024
University of Münster
2009-2019
University Hospital Münster
2009-2019
Charité - Universitätsmedizin Berlin
2015
Background: Although an orphan disease with still obscure aetiopathogenesis, Susac syndrome has to be considered as differential diagnosis in multiple sclerosis (MS), since its clinical presentation and paraclinical features including routine magnetic resonance imaging (MRI) findings partially overlap. Objective: We aimed study a potential benefit of 7T MRI for (i) the differentiation between MS (ii) clarification pathogenesis syndrome. Methods: Five patients suffering from syndrome, 10 sex-...
Abstract Neuroinflammation is often associated with blood-brain-barrier dysfunction, which contributes to neurological tissue damage. Here, we reveal the pathophysiology of Susac syndrome (SuS), an enigmatic neuroinflammatory disease central nervous system (CNS) endotheliopathy. By investigating immune cells from blood, cerebrospinal fluid, and CNS SuS patients, demonstrate oligoclonal expansion terminally differentiated activated cytotoxic CD8 + T (CTLs). Neuropathological data derived both...
Susac syndrome (SuS) is a rare disorder thought to be caused by autoimmune-mediated occlusions of microvessels in the brain, retina and inner ear leading central nervous system (CNS) dysfunction, visual disturbances due branch retinal artery (BRAO), hearing deficits. Recently, role for anti-endothelial cell antibodies (AECA) SuS has been proposed. To report clinical paraclinical findings largest single series patients so far investigate frequency, titers, relevance AECA SuS. A total 107...
Optical coherence tomography angiography (OCT-A) represents the most recent tool in ophthalmic imaging. It allows for a non-invasive, depth-selective and quantitative visualization of blood flow central retinal vessels it has an enormous diagnostic potential not only ophthalmology but also with regards to neurologic systemic diseases. Cerebral autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy (CADASIL) is hereditary vascular small-vessel disease caused by Notch3...
Abstract Epstein-Barr virus (EBV) infection has long been associated with the development of multiple sclerosis (MS). Patients MS have elevated titres EBV-specific antibodies in serum and show signs CNS damage only after EBV infection. Regarding CD8+ T cells, an but ineffective response to was suggested patients, who present a broader MHC-I-restricted T-cell receptor beta chain (TRB) repertoire compared controls. It is not known whether this altered could be subject dynamic changes, e.g. by...
The aim of this non-interventional study was to characterize retinal layer pathology in Susac syndrome (SuS), a disease with presumably autoimmune-mediated microvessel occlusions the retina, brain, and inner ear, comparison most important differential diagnosis multiple sclerosis (MS).Seventeen patients SuS 17 age- sex-matched relapsing-remitting MS (RRMS) healthy controls (HC) were prospectively investigated by spectral-domain optical coherence tomography (OCT) including intraretinal...
Susac syndrome, a rare but probably underdiagnosed combination of encephalopathy, hearing loss, and visual deficits due to branch retinal artery occlusion unknown aetiology has be considered as differential diagnosis in various conditions. Particularly, differentiation from multiple sclerosis is often challenging since both clinical presentation diagnostic findings may overlap. Optical coherence tomography powerful easy perform tool analyse the morphological integrity structures increasingly...
To report on dysphagia as initial sign in a case of anti-IgLON5 syndrome and provide an overview the current literature.The diagnostic workup included cerebral MRI, fiber optic endoscopic evaluation swallowing (FEES) with FEES tensilon test, videofluoroscopic study, evoked potentials peripheral nerve conduction studies, polysomnography, lumbar puncture, screening for neural autoantibodies. A systematic review all published cases IgLON5 is provided.We presenting slowly progressive neurogenic...
Some patients develop severe brain edema after complete middle cerebral artery occlusion, whereas others do not. Aquaporin-4 (AQP4) is the main water channel in and has been shown to be critical for development of ischemia. We asked whether genetic variation AQP4 gene related severity occlusion.We genotyped 10 single nucleotide polymorphisms distributed across 41 with occlusion without assessed marker association as well linkage dysequilibrium structure AQP4.One polymorphism (rs9951307) at...
To investigate the prevalence of fatigue, daytime sleepiness, reduced sleep quality, and restless legs syndrome (RLS) in a large cohort patients with Charcot-Marie-Tooth disease (CMT) their impact on health-related quality life (HRQoL). Participants web-based survey answered Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Multidimensional Fatigue Inventory, and, if diagnostic criteria RLS were met, International Severity Scale. Diagnosis was affirmed screen-positive by means...
SummaryBackgroundEmerging evidence suggests that endovascular thrombectomy is beneficial for treatment of childhood stroke, but the safety and effectiveness has not been compared with best medical treatment. We aimed to prospectively analyse functional outcomes versus in children intracranial arterial occlusion stroke.MethodsIn this prospective registry study, 45 centres 12 countries across Asia Australia, Europe, North America, South America reported aged between 28 days 18 years presenting...
Susac syndrome is a rare disease, characterized by the triad of hearing loss, branch retinal artery occlusions, and encephalopathy with predominantly cognitive psychiatric symptoms.1,2 Focal ischemic lesions in corpus callosum detectable conventional MRI are typical feature syndrome.3,4 The do not, however, explain type severity neuropsychological deficits.5,6 In this study, we tested hypothesis whether widespread tissue damage otherwise normal-appearing white matter (NAWM) could be...
Ascorbic acid (vitamin C) is necessary for myelination of Schwann cell/neuron cocultures and has shown beneficial effects in the treatment a Charcot-Marie-Tooth neuropathy 1A (CMT1A) mouse model. Although clinical studies revealed that ascorbic had no impact on CMT1A, it assumed to have an important function peripheral nerve possibly remyelination. However, transport pathway into nerves mechanism vivo remained unclear. In this study, we used sodium-dependent vitamin C transporter...
To describe retinal lesion development in Susac syndrome during acute, postacute, and late phases of the disease.Cross-sectional study four patients with longitudinal short-interval case one additional patient. Retinal changes were analyzed high-resolution spectral domain optical coherence tomography fluorescein angiography.Retinal lesions comprise different sections, which can be distinguished acute postacute disease: a primary section at site branch artery occlusion, spans more layers than...
Cardiac embolism is presumed to cause a significant portion of cryptogenic strokes. Transesophageal echocardiography may detect intracardiac thrombi, but this remains rare finding, possibly because remnant clots dissolve spontaneously or following thrombolysis. imaging within cerebral CT angiography might offer an alternative method for thrombus detection hyperacute stroke assessment. In proof-of-concept study we analyzed records patients aged ≥60 years that presented with suspected and...
Abstract N‐cadherin and β‐catenin are involved in cell adhesion cycle tumor cells neural crest. Both expressed at key stages of Schwann (SC) development, but little is known about their function the SC lineage. We studied role these molecules adult rat derived SC‐embryonic dorsal root ganglion cocultures by using low‐Ca 2+ conditions specific blocking antibodies to interfere with small interfering RNA (siRNA) decrease expression both SC‐neuron rat‐derived monocultures. decreased SC‐axon...
Introduction. Eclampsia is the combination of preeclampsia and seizures. Approximately one-half all cases eclampsia occur postpartum. Thereby late onset postpartum defined by its more than 48 hours after delivery. Summary Case. We report a occurring 8 weeks delivery, which latest ever described. The course was complicated an intracerebral hemorrhage (ICH). Conclusion. A even several delivery should be considered as possible diagnosis, since early treatment initiation with magnesium sulphate...
Background and purpose Detection of occult atrial fibrillation ( AF ) is crucial for optimal secondary prevention in stroke patients. The detection rate was determined by implantable cardiac monitor ICM compared to the prediction probability incident software based analysis a continuously monitored electrocardiogram at follow‐up (stroke risk analysis, SRA ); an optimized algorithm proposed combining both tools. Methods In monocentric prospective study 105 out 389 patients with cryptogenic...