A5049769160- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Advanced Neuroimaging Techniques and Applications
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- Ultrasound Imaging and Elastography
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Ultrasound and Hyperthermia Applications
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Viral Infections and Immunology Research
- Cerebral Venous Sinus Thrombosis
- Polyomavirus and related diseases
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Glioma Diagnosis and Treatment
- Neurological diseases and metabolism
- Neurogenesis and neuroplasticity mechanisms
- Ophthalmology and Eye Disorders
- Rheumatoid Arthritis Research and Therapies
- Photoacoustic and Ultrasonic Imaging
- CNS Lymphoma Diagnosis and Treatment
- Cellular Mechanics and Interactions
Roche (Greece)
2025
Humboldt-Universität zu Berlin
2018-2024
Charité - Universitätsmedizin Berlin
2014-2024
Freie Universität Berlin
2018-2024
Max Delbrück Center
2008-2024
The University of Sydney
2024
Palacký University Olomouc
2024
The University of Western Australia
2024
Düsseldorf University Hospital
2024
Université de Bordeaux
2024
Neuro-axonal injury is a key factor in the development of permanent disability multiple sclerosis. Neurofilament light chain peripheral blood has recently emerged as biofluid marker reflecting neuro-axonal damage this disease. We aimed at comparing serum neurofilament levels sclerosis and healthy controls, to determine their association with measures disease activity ability predict future clinical worsening well brain spinal cord volume loss. was measured by single molecule array assay 2183...
Viscoelastic properties indicate structural alterations in biological tissues at multiple scales with high sensitivity. Magnetic Resonance Elastography (MRE) is a novel technique that directly visualizes and quantitatively measures biomechanical tissue vivo. MRE recently revealed early relapsing-remitting sclerosis (MS) associated global decrease of the cerebral mechanical integrity. This study addresses MR volumetry chronic-progressive disease courses MS.We determined viscoelastic...
The detection of pathological tissue alterations by manual palpation is a simple but essential diagnostic tool, which has been applied physicians since the beginnings medicine. Recently, virtual "palpation" brain become feasible using magnetic resonance elastography, quantifies biomechanical properties parenchyma analyzing propagation externally elicited shear waves. However, precise molecular and cellular patterns underlying changes viscoelasticity measured elastography have not...
The central vein sign has been proposed as a specific imaging biomarker for distinguishing between multiple sclerosis (MS) and not MS, mainly based on findings from ultrahigh-field magnetic resonance (MRI) studies. diagnostic value of the in multicenter setting with variety clinical 3 tesla (T) MRI protocols, however, remains unknown.To evaluate sensitivity specificity various lesion criteria differentiating MS non-MS conditions using 3T brain commonly used pulse sequences.This large...
The Virchow-Robin spaces (VRS), perivascular compartments surrounding small blood vessels as they penetrate the brain parenchyma, are increasingly recognized for their role in leucocyte trafficking well potential to modulate immune responses. In present study, we investigated VRS numbers and volumes different regions 45 multiple sclerosis patients 30 healthy controls of similar age gender distribution, applying three MRI sequence modalities (T(2)-weighted, T(1)-weighted FLAIR). were detected...
New MRI techniques such as the analysis of magnetization transfer or diffusion have provided evidence for subtle progressive alterations in tissue integrity prior to focal leakage blood-brain barrier (BBB) part plaque formation multiple sclerosis. Since inflammation is capable modulating microcirculation, we investigated hypothesis that changes local perfusion might be one earliest signs lesion development. 20 patients with definite relapsing-remitting sclerosis were analysed regard cerebral...
To investigate distinct white matter and cortical gray pathology in neuromyelitis optica spectrum disorders (NMOSDs) multiple sclerosis (MS) at 7-T MRI a cross-sectional study.We included 10 patients with NMOSDs 18 MS our study. The imaging protocol comprised T2*-weighted fast low angle shot turbo inversion recovery magnitude sequences. White lesions were assessed special regard to their (perivascular) localization as well the expression of hypointense rim.In total, we detected 140 7 NMOSDs....
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune with a characteristic neuropsychiatric syndrome and severe prolonged clinical courses. In contrast, standard magnetic resonance imaging (MRI) remains normal in the majority of patients. Here, we investigated structural functional brain changes cohort patients anti-NMDAR encephalitis.Twenty-four established diagnosis age- gender-matched controls underwent neuropsychological testing multimodal MRI, including T1w/T2w...
Background: Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis, but its pathophysiological mechanisms are poorly understood. It particular unclear whether how fatigue relates to structural functional brain changes. Objective: We aimed analyse association severity with basal ganglia connectivity, volumes, white matter integrity grey density. Methods: In 44 patients relapsing–remitting sclerosis 20 age- gender-matched healthy controls, resting-state fMRI,...
Background: Although an orphan disease with still obscure aetiopathogenesis, Susac syndrome has to be considered as differential diagnosis in multiple sclerosis (MS), since its clinical presentation and paraclinical features including routine magnetic resonance imaging (MRI) findings partially overlap. Objective: We aimed study a potential benefit of 7T MRI for (i) the differentiation between MS (ii) clarification pathogenesis syndrome. Methods: Five patients suffering from syndrome, 10 sex-...
To generate high-resolution maps of the viscoelastic properties human brain parenchyma for presurgical quantitative assessment in glioblastoma (GB).Twenty-two GB patients underwent routine work-up supplemented by additional multifrequency magnetic resonance elastography. Two three-dimensional parameter maps, magnitude |G*|, and phase angle φ complex shear modulus were reconstructed inversion full wave field data 2-mm isotropic resolution at seven harmonic drive frequencies ranging from 30 to...
Neuroaxonal degeneration in the central nervous system contributes substantially to long term disability multiple sclerosis (MS) patients. However, vivo determination and monitoring of neurodegeneration remain difficult. As widely used MRI-based approaches, including brain parenchymal fraction (BPF) have some limitations, complementary measures for are necessary. Optical coherence tomography (OCT) is a potent tool detection MS-related retinal neurodegeneration. crucial aspects association...
Background: Retinal nerve fibre layer (RNFL) thinning is associated with brain atrophy in multiple sclerosis (MS). An influence of optic neuritis well documented but sparsely investigated. Recently, the retinal ganglion cell (GCL) has been shown to provide superior information regarding visual function and neurodegeneration as compared RNFL. Objective: To investigate association white grey matter volume peripapillary RNFL macular GCL MS patients without a history neuritis. Methods: 63...