A5020423205- Ultrasound Imaging and Elastography
- Elasticity and Material Modeling
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cellular Mechanics and Interactions
- Ultrasonics and Acoustic Wave Propagation
- Pancreatitis Pathology and Treatment
- Photoacoustic and Ultrasonic Imaging
- Crystallography and molecular interactions
- Electrical and Bioimpedance Tomography
- Molecular spectroscopy and chirality
- Cardiovascular Health and Disease Prevention
- Liver physiology and pathology
- Global Health Care Issues
- Advanced Neuroimaging Techniques and Applications
- Liver Disease and Transplantation
- Blood properties and coagulation
- Molecular Sensors and Ion Detection
- Neonatal Respiratory Health Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Health disparities and outcomes
- Bone health and osteoporosis research
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2005-2025
Freie Universität Berlin
2012-2025
Zhengzhou University
2010-2024
Zhengzhou Children's Hospital
2023-2024
Northwest Women's and Children's Hospital
2023
Tianjin University of Science and Technology
2013-2022
Qiqihar Medical University
2022
Wuhan Institute of Bioengineering
2022
National Clinical Research
2021
Abstract Hydrogen bond geometries and 1 H NMR chemical shifts of OHO hydrogen‐bonded systems have been analyzed using an improved valence order model. This model predicts that the heavy atom hydrogen coordinate q 2 = r + is a function proton ( ‐ ), where represent OH HO distances. In first part, it shown this correlation reproduces published equilibrium Zundel cation 5 O as well those water clusters in gas phase embedded fullerene C180. Using example hexamer, changing level calculation...
To generate high-resolution maps of the viscoelastic properties human brain parenchyma for presurgical quantitative assessment in glioblastoma (GB).Twenty-two GB patients underwent routine work-up supplemented by additional multifrequency magnetic resonance elastography. Two three-dimensional parameter maps, magnitude |G*|, and phase angle φ complex shear modulus were reconstructed inversion full wave field data 2-mm isotropic resolution at seven harmonic drive frequencies ranging from 30 to...
Purpose Viscoelastic properties of the liver are sensitive to fibrosis. This study proposes several modifications existing magnetic resonance elastography (MRE) techniques improve accuracy abdominal MRE. Methods The proposed method comprises following steps: (i) wave generation by a nonmagnetic, piezoelectric driver suitable for integration into patient table, (ii) fast single‐shot 3D wave‐field acquisition at four drive frequencies between 30 and 60 Hz, (iii) single‐step postprocessing...
Cerebral viscoelastic constants can be measured in a noninvasive, image-based way by magnetic resonance elastography (MRE) for the detection of neurological disorders. However, MRE brain maps are still limited low spatial resolution. Here we introduce three-dimensional multifrequency combined with novel reconstruction algorithm based on model-free inversion calculating spatially resolved parameter human corresponding to dynamic range shear oscillations between 30 and 60 Hz. Maps two...
Patients with increased liver stiffness have a higher risk of developing cancer, however, the role fluid-solid tissue interactions and their contribution to tumor malignancy remains elusive. Tomoelastography is novel imaging method for mapping quantitatively solid-fluid properties soft tissues in vivo. It provides high resolution thus has clear clinical applications. In this work we used tomoelastography 77 participants, total 141 focal lesions different etiologies, investigate contributions...
Abstract Objectives The capability of MR elastography (MRE) to differentiate fibrosis and inflammation, provide precise diagnoses is crucial, whereas the coexistence inflammation may obscure diagnostic accuracy. Methods In this retrospective study, from June 2020 December 2022, chronic viral hepatitis patients who underwent multifrequency MRE (mMRE) were included in, further divided into, training validation cohorts. hepatic viscoelastic parameters [shear wave speed ( c ) loss angle φ...
To demonstrate the feasibility of in vivo wideband MR elastography (wMRE) using continuous, time-harmonic shear vibrations frequency range 10-50 Hz.The method was tested a gel phantom with marked mechanical loss. The brains and livers eight volunteers were scanned by wMRE multislice, single-shot MRE optimized fractional encoding synchronization sequence acquisition to vibration. Multifrequency three-dimensional inversion used reconstruct compound maps magnitude |G*| phase φ complex modulus....
Background/Aims: Diabetes mellitus (DM) characterized by hyperglycemia contributes to macrovascular and microvascular complications. Salvianolic acid A (SalA) is a polyphenolic compound isolated from the root of Salvia miltiorrhiza Bunge, which traditional Chinese medicine widely used treat cardiovascular diseases. However, little known about its antidiabetic effect. Our study aimed investigate in vivo vitro effect SalA underlying mechanisms. Methods: Alloxan-induced type 1 diabetic mice...
To develop a compact magnetic resonance elastography (MRE) protocol for abdomen and to investigate the effect of water uptake on tissue stiffness in liver, spleen, kidney, pancreas.Nine asymptomatic volunteers were investigated by MRE before after 1 liter uptake. Shear-wave excitation at four frequencies was transferred from anterior posterior directions using pressurized air drivers. Tomographic representations shear-wave speed produced analysis multifrequency wave numbers axial coronal...
Objective The objective of this study was to investigate the correlation between hepatic venous pressure gradient (HVPG) and in vivo viscoelasticity liver spleen before after transjugular intrahepatic portosystemic shunt (TIPS) implantation. Materials Methods Ten patients with portal hypertension were examined twice by 3-dimensional multifrequency magnetic resonance elastography as well prior subsequent TIPS intervention; HVPG also measured during placement. Five harmonic vibrations (25–60...
To investigate in vivo viscoelastic parameters related to early histopathological changes the hippocampus and cortex early, preclinical Alzheimer's disease (AD) stages.Magnetic resonance elastography (MRE) was applied female APP23 mice, an established transgenic mouse model of AD, at three different stages progression. potential therapeutic effects physical, cognitive, social stimulation on brain viscoelasticity characteristics, MRE also after exposing young mice environmentally enriched...
Abstract Whether metabolites derived from injured renal tubular epithelial cells (TECs) participate in fibrosis is poorly explored. After TEC injury, various are released and among the most potent adenosine triphosphate (ATP), which via ATP-permeable channels. In these hemichannels, connexin 43 (Cx43) common member. However, its role interstitial (RIF) has not been fully examined. We analyzed samples patients with obstructive nephropathy mice unilateral ureteral obstruction (UUO). Cx43-KSP...
This study aimed to explore the added value of viscoelasticity measured by magnetic resonance elastography (MRE) in prediction Ki-67 expression hepatocellular carcinoma (HCC) using a deep learning combined radiomics (DLCR) model. retrospective included 108 histopathology-proven HCC patients (93 males; age, 59.6 ± 11.0 years) who underwent preoperative MRI and MR elastography. They were divided into training (n = 87; 61.0 9.8 testing 21; 60.6 10.1 cohorts. An independent validation cohort...
The aim of this study was to investigate the influence neuronal density on viscoelastic parameters living brain tissue after ischemic infarction in mouse using MR elastography (MRE). Transient middle cerebral artery occlusion (MCAO) left hemisphere induced 20 mice. In vivo 7‐T MRE at a vibration frequency 900 Hz performed days 3, 7, 14 and 28 ( n = 5 per group) MCAO, followed by analysis histological markers, such as neuron counts (NeuN). MCAO led significant reduction storage modulus...
Purpose Waveguide elastography (WGE) combines magnetic resonance (MRE), diffusion tensor imaging (DTI), and anisotropic inversions for a determination of the elastic properties white matter. Previously, method evaluated corticospinal tracts (CSTs) healthy volunteers. Here, sensitivity WGE is tested detection pathologic changes in cohort patients with Amyotrophic Lateral Sclerosis (ALS). Methods MRE DTI were performed 14 ALS healthy, age‐matched controls. A comparison was made between three...
Recent advances in dynamic elastography and biorheology have revealed that the complex shear modulus, G*, of various biological soft tissues obeys a frequency-dependent powerlaw. This viscoelastic powerlaw behavior implies mechanical properties are communicated tissue across continuum scales from microscopic to macroscopic. For deriving constitutive constants dispersion G* tissue, hierarchical fractal model is introduced accounts for multiscale networks. Effective-media derived by law based...
Magnetic resonance elastography (MRE) is an imaging method that reveals the mechanical properties of tissue, modelled as a combination " viscosity" and elasticity" . We recently showed reduced brain viscoelasticity in multiple sclerosis (MS) patients compared with healthy controls, relapsing–remitting disease model experimental autoimmune encephalomyelitis (EAE). However, mechanisms by which these intrinsic tissue become altered remain unclear. This study investigates whether distinct...