A5101909857- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Lanthanide and Transition Metal Complexes
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Vestibular and auditory disorders
- Functional Brain Connectivity Studies
- Salivary Gland Disorders and Functions
- Bone and Joint Diseases
- Head and Neck Cancer Studies
- Cerebrovascular and Carotid Artery Diseases
- Metabolomics and Mass Spectrometry Studies
- Gynecological conditions and treatments
- Atomic and Subatomic Physics Research
- Peripheral Nerve Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Parkinson's Disease Mechanisms and Treatments
- Effects of Radiation Exposure
- Hearing, Cochlea, Tinnitus, Genetics
Philips (China)
2016-2025
Guangzhou Medical University
2025
The First People's Hospital of Changzhou
2024
China Academy of Art
2024
Yantai University
2024
Chengdu University of Technology
2023
Soochow University
2019
East China Normal University
2009-2019
Nanjing Drum Tower Hospital
2016
Emory University
2016
Many modalities of magnetic resonance imaging (MRI) have been confirmed to be great diagnostic value in glioma grading. Contrast enhanced T1-weighted allows the recognition blood-brain barrier breakdown. Perfusion weighted and MR spectroscopic enable quantitative measurement perfusion parameters metabolic alterations respectively. These can potentially improve grading process if combined properly. In this study, Bayesian Network, which is a powerful flexible method for probabilistic analysis...
Purpose To determine whether there are in vivo differences of γ-aminobutyric acid (GABA) levels frontal and parietal regions Alzheimer's disease (AD) patients, compared with healthy controls using magnetic resonance spectroscopy (1H-MRS). Materials Methods Fifteen AD patients fifteen age- gender-matched underwent 1H-MRS the lobes "MEGA-Point Resolved Spectroscopy Sequence" (MEGA-PRESS) technique, cognitive subjects were evaluated Mini-Mental State Examination (MMSE) tests. MRS data processed...
Objective: Accurate segmentation of liver tumors, which could help physicians make appropriate treatment decisions and assess the effectiveness surgical treatment, is crucial for clinical diagnosis cancer. In this study, we propose a 4-dimensional (4D) deep learning model based on 3D convolution convolutional long short-term memory (C-LSTM) hepatocellular carcinoma (HCC) lesion segmentation. Methods: The proposed utilizes 4D information dynamic contrast enhanced (DCE) magnetic resonance...
Deep learning based generative adversarial networks (GAN) can effectively perform image reconstruction with under-sampled MR data. In general, a large number of training samples are required to improve the performance certain model. However, in real clinical applications, it is difficult obtain tens thousands raw patient data train model since saving k-space not routine flow. Therefore, enhancing generalizability network on small urgently needed. this study, three novel applications were...
Medical image-to-image translation is considered a new direction with many potential applications in the medical field. The dominated by two models, including supervised Pix2Pix and unsupervised cyclic-consistency generative adversarial network (GAN). However, existing methods still have shortcomings: 1) requires paired pixel-aligned images, which are difficult to acquire. Nevertheless, optimum output of cycle-consistency model may not be unique. 2) They deficient capturing global features...
Abstract Diffusion‐derived vessel density (DVDD) is a physiological surrogate of the area microvessels per unit tissue area. DDVD calculated according to DDVD(b0b2) = Sb0/ROIarea0 – Sb2/ROIarea2, where Sb0 and Sb2 refer liver signal when b 0 or 2 s/mm . Pathohistological studies contrast‐enhanced CT/MRI data showed higher blood volume in hepatocellular carcinoma (HCC) relative native tissue. With intravoxel incoherent motion (IVIM) imaging, most authors paradoxically reported decreased...
Presbycusis (PC) is characterized by bilateral sensorineural hearing loss at high frequencies and speech-perception difficulties in noisy environments has a strikingly detrimental impact on cognitive function. As the neural consequences of PC may involve whole brain, we hypothesized that patients with would show structural alterations not only auditory cortex but also cortexes involved The purpose this study was to use surface-based morphometry (SBM) analysis elucidate whole-brain...
This study aimed to explore the added value of viscoelasticity measured by magnetic resonance elastography (MRE) in prediction Ki-67 expression hepatocellular carcinoma (HCC) using a deep learning combined radiomics (DLCR) model. retrospective included 108 histopathology-proven HCC patients (93 males; age, 59.6 ± 11.0 years) who underwent preoperative MRI and MR elastography. They were divided into training (n = 87; 61.0 9.8 testing 21; 60.6 10.1 cohorts. An independent validation cohort...
Purpose To explore the clinical value of diffusion kurtosis imaging (DKI) and monoexponential diffusion‐weighted (DWI) for predicting early response to neoadjuvant chemotherapy (NAC) in patients with nasopharyngeal carcinoma (NPC). Materials Methods Fifty‐nine stage III‐IVb NPC underwent four 3.0T MR scans: prior to, on 4th, 21st, 42nd days after NAC initiation. The parameters DKI (corrected coefficient, D; excess K) DWI (apparent ADC) were obtained at first three scans. Statistical methods...
Intravoxel incoherent motion (IVIM) MR imaging has been applied in researches of various diseases, however its potential cervical cancer patients not fully explored. The purpose this study was to investigate the feasibility IVIM monitor early treatment response receiving concurrent chemo-radiotherapy (CCRT) for advanced cancers. Twenty-one CCRT were prospectively enrolled. examinations including (with 14 b values, 0 ~ 1000 s/mm2) performed at 4 time points: 1-week prior to, 2-week and 4-week...
The glymphatic system may play a central role in cognitive impairment associated with Parkinson's disease, but its relationship regional cortical atrophy is not fully explored. To explore associations among dysfunction, degeneration and disease participants, we evaluated 51 participants documented (28 men; age, 61.65 ± 8.27 years) 30 age- sex-matched normal controls (11 59.2 5.90 who underwent 3.0-T MRI of the brain, including high-resolution T1-weighted imaging diffusion-tensor along...
Talaromyces marneffei is an emerging pathogen, and the number of infections in HIV-negative individuals increasing. In individuals, talaromycosis usually misdiagnosed as another disease, especially tuberculosis (TB). We retrospectively extracted clinical data patients with infection from 2018 to 2023, analyzed differences between TB attempted establish differential diagnosis models utilizing prediction for these two diseases. Overall, 718 patients, including 137 581 pulmonary (PTB), were...
Purpose To prospectively evaluate the dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) value for predicting early nasopharyngeal carcinoma (NPC) chemoradiotherapy (CRT) response. Materials and Methods Forty‐two patients with advanced NPC were recruited received three DCE‐MRI exams before treatment (Pre‐Tx), as well 3 days (Day 3‐Tx) 40 40‐Tx) after chemotherapy initiation (two neoadjuvant cycles, NAC). We used DCE‐Tool to measure primary tumor kinetic parameters ( K trans , ep...
Purpose To investigate the effects of frequency drift on chemical exchange saturation transfer (CEST) imaging at 3T, and to propose a new sequence for correcting artifacts attributed B 0 in real time. Theory Methods A frequency‐stabilized CEST (FS‐CEST) was proposed by adding stabilization module conventional non‐frequency‐stabilized (NFS‐CEST) sequence, which consisted small tip angle radiofrequency excitation pulse readout three non‐phase‐encoded k ‐space lines. Experiments were performed...
Abstract Purpose To acquire the mobile macromolecule (MM) spectrum from healthy participants, and to investigate changes in signals with age sex. Methods 102 volunteers (49 M/53 F) between 20 69 years were recruited for vivo data acquisition centrum semiovale (CSO) posterior cingulate cortex (PCC). Spectral acquired at 3T using PRESS localization a voxel size of 30 × 26 mm 3 , pre‐inversion (TR/TI 2000/600 ms) CHESS water suppression. Metabolite‐nulled spectra modeled eliminate residual...
The neurometabolic timecourse of healthy aging is not well-established, in part due to diversity quantification methodology. In this study, a large structured cross-sectional cohort male and female subjects throughout adulthood was recruited investigate changes as function age, using consensus-recommended magnetic resonance spectroscopy methods.102 volunteers, with approximately equal numbers participants each decade age from the 20s, 30s, 40s, 50s, 60s, were IRB approval. MR spectroscopic...
The total variation (TV) model is one kind of second-order partial differential equation (PDE) for image noise removal. However, the PDEs suffer from so-called staircase effect. Proposed a modified TV (MTV) model, which staircase-free by minimising along direction tangential to isophotes original image. Its effectiveness in preserving edges, avoiding staircases and removing noises shown experiment comparison.
Purpose To evaluate the relationship between quantitative parameters of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) and clinical stage nasopharyngeal carcinoma (NPC). Materials Methods Fifty‐one newly diagnosed NPC patients received MRI examination on Philips Achieva 3.0 Tesla TX MR system. We used DCE‐Tool (Philips Healthcare, Best, The Netherlands) to investigate from primary tumors. Tumor/node/metastasis corresponding stages were determined based 2009 UICC 7th edition....
Background Parkinson's disease (PD) is divided into postural instability gait difficulty (PIGD) and tremor‐dominant (TD) subtypes. Increasing evidence has suggested that the GABAergic neurotransmitter system involved in pathogenesis of PD. Purpose To evaluate differences GABA levels between PD motor subtypes using MEscher‐GArwood Point Resolved Spectroscopy (MEGA‐PRESS). Study Type: Cohort. SUBJECTS: patients were classified PIGD ( n = 13) TD groups 9); 16 age‐ sex‐matched healthy controls...