A5054692652- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Nanoplatforms for cancer theranostics
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Domain Adaptation and Few-Shot Learning
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Extracellular vesicles in disease
- Memory and Neural Mechanisms
- Phytochemistry and Biological Activities
- Photodynamic Therapy Research Studies
- Bayesian Modeling and Causal Inference
- Optical Imaging and Spectroscopy Techniques
- Brain Tumor Detection and Classification
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Heme Oxygenase-1 and Carbon Monoxide
- MRI in cancer diagnosis
Nanjing Drum Tower Hospital
2016-2025
Xiamen University
2025
George Mason University
2023-2024
Yunnan University
2021-2023
Jiangsu Province Blood Center
2018-2020
Nanjing University
2020
Guangxi University of Chinese Medicine
2019
Guangxi University
2019
Southeast University
2016
State Key Laboratory of Digital Medical Engineering
2016
Many modalities of magnetic resonance imaging (MRI) have been confirmed to be great diagnostic value in glioma grading. Contrast enhanced T1-weighted allows the recognition blood-brain barrier breakdown. Perfusion weighted and MR spectroscopic enable quantitative measurement perfusion parameters metabolic alterations respectively. These can potentially improve grading process if combined properly. In this study, Bayesian Network, which is a powerful flexible method for probabilistic analysis...
Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) have overlapping symptoms, accurate differential diagnosis is important for targeted intervention treatment. Previous studies suggest that the deep learning (DL) techniques potential to solve problem of FTD, AD normal controls (NCs), but its performance still unclear. In addition, existing DL-assisted diagnostic rely on hypothesis-based expert-level preprocessing. On one hand, it imposes high requirements clinicians data themselves;...
Abstract Ischemic stroke leads to white matter damage and neurological deficits. However, the characteristics of injury repair after are unclear. Additionally, precise molecular communications between microglia during rehabilitation phase remain elusive. In this current study, MRI DTI scan immunofluorescence staining were performed trace in mouse transient middle cerebral artery occlusion (tMCAO) model. We found that most serious was on Day 7 ischemic stroke, then it recovered gradually from...
Deep gray matter structures are associated with memory and other important functions that impaired in Alzheimer's disease (AD) mild cognitive impairment (MCI). However, systematic characterization of the subregional atrophy deformations these AD MCI still need more investigations. In this article, we combined complex volumetry- vertex-based analysis to investigate pattern structural alterations deep its association global clinical scores (n = 30) patients 30), compared normal controls (NCs,...
Background and Objective: Subjective cognitive decline (SCD) is considered a preclinical state of Alzheimer's disease (AD) may represent more advanced status than amnestic mild impairment (aMCI). Our aim was to explore changes in the white matter (WM) microstructure their correlation with function these AD-spectrum patients. Methods: Diffusion tensor images from 43 individuals normal cognition (NC), 38 SCD patients, 36 aMCI patients were compared using an atlas-based segmentation strategy....
Vascular dementia (VAD) is the second most common type of lacking effective treatments. Pentoxifylline (PTX), a nonselective phosphodiesterase inhibitor, displays protective effects in multiple cerebral diseases. In this study, we aimed to investigate therapeutic and potential mechanisms PTX VAD.Bilateral carotid artery stenosis (BCAS) mouse model was established mimic VAD. Mouse behavior tested by open field test, novel object recognition Y-maze Morris water maze (MWM) tests. Histological...
Brain white matter fiber bundles in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) have abnormalities not usually seen unaffected subjects. Ideal algorithm of the localization-specific properties integrity might reveal changes tissue varying along each tract, while previous studies only detected mean DTI parameters fiber. The aim this study was to investigate whether these nerve tracts are localized specific regions or spread throughout analyze which examined...
Blood vessel segmentation in fundus images is necessary for the diagnosis of ophthalmic diseases. In recent years, deep learning has achieved eminent performance blood segmentation, and there still exist challenges to reduce misidentification improve microvascular accuracy. One reason that traditional Convolutional Neural Network (CNN) can not effectively extract multiscale information discard unnecessary information. Another we can't explain why some vessels fail be identified. On one hand,...
Hypoxia plays an important role in the progression of atherosclerosis. However, ameliorating hypoxia at atherosclerotic lesions remains a great challenge. To achieve targeted oxygen delivery to plaques, Lipid 5-doped, platelet membrane-encapsulated magnetic mesoporous organosilicon nanoparticles loaded with perfluoro-15-crown ether (PFCE) (FMMON@PL) were prepared. PFCE worked as carrier, while iron oxide (IONPs) acted nanozymes catalase-like activity facilitate generation. enhance plaque...
ABSTRACT Background Platinum can cause chemotherapy‐related cognitive impairment. Low‐intensity focused ultrasound (LIFUS) is a promising noninvasive physical stimulation method with unique advantage in neurological rehabilitation. We aimed to investigate whether LIFUS alleviate cisplatin‐induced impairment rats and explore the related neuropathological mechanisms. Methods After confirming target position for treatment 18 rats, 64 were randomly divided into four groups: control, model, sham,...
Cerenkov light (CL), utilized as an internal excitation source for photodynamic therapy (PDT), addresses the limitations of laser penetration and has substantial potential seamlessly integrating clinical radiotheranostics with phototheranostics. Nevertheless, effectiveness CL-mediated PDT is significantly hindered by challenges, such low intensity CL inadequate energy transfer between donor photosensitizers (PSs). In this study, a novel approach introduced enhanced radionuclide-activated...
Abstract The purpose of this study is to investigate the characteristics intracranial vessel wall enhancement and its relationship with ischemic infarction in patients Moyamoya vasculopathy (MMV). Forty-seven MMV confirmed by angiography were enrolled study. distal internal carotid artery, anterior cerebral artery middle was classified into eccentric concentric patterns, as well divided three grades: grade 0, 1 2. between also determined. Fifty-six enhanced lesions found (n = 25) without...
Background:Lacunar infarctions (LI) have been associated with a cognitive decline and an increased risk of dementia. Whether how the pattern spontaneous brain activity in patients mild impairment (MCI) differs subjects without concomitant LI remains unclear. Object ive:To compare MCI versus those using resting-state functional magnetic resonance imaging (rs-fMRI). Methods:Forty-eight patients, including 22 [MCI-LI] 26 [MCI-no LI], 28 normal underwent rs-fMRI post-processed regional...
Abstract To evaluate the potential clinical value of time-shift analysis (TSA) approach for resting-state fMRI (rs-fMRI) blood oxygenation level-dependent (BOLD) data in detecting hypoperfusion subacute stroke patients through comparison with dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI). Forty (3–14 days after neurological symptom onset) underwent MRI examination. Cohort A: 31 had MRA, DSC-PWI and BOLD data. B: 9 MRA The time delay between course each voxel mean...
Abstract Chronic cerebral hypoperfusion is one of the pathophysiological mechanisms contributing to cognitive decline by causing white matter injury. Microglia phagocytosing myelin debris in a timely manner can promote remyelination and contribute repair matter. However, milk fat globule-epidermal growth factor-factor 8 (MFG-E8), microglial phagocytosis-related protein, has not been well studied hypoperfusion-related dysfunction. We found that expression MFG-E8 was significantly decreased...
<b><i>Objective:</i></b> To explore the within- and between-network patterns of default mode network (DMN), frontoparietal control (FPCN), dorsal attention (DAN) in cerebral small vessel disease (CSVD) with without cognitive impairment (CI). <b><i>Methods:</i></b> Twenty CSVD CI subjects, 21 25 healthy elderly controls were recruited. The networks identified based on resting-state functional magnetic resonance imaging data....
Neuroimaging evidence has suggested white matter microstructure are heavily affected in Alzheimer's disease (AD). However, whether dysfunction is localized at the specific regions of fiber tracts and they would be a potential biomarker for AD remain unclear. By automated quantification (AFQ), we applied diffusion tensor images from 25 healthy controls (HC), 24 amnestic mild cognitive impairment (aMCI) patients 18 to create tract profiles along 16 major fibers. We compared metrics [Fractional...
Macrophage accumulation is central to the pathogenesis of atherosclerotic plaques. Reducing macrophages in plaques an appealing approach attenuate development atherosclerosis. Chemodynamic therapy, specifically inhibiting hydrogen peroxide (H2O2)-rich cells slightly acidic microenvironment, has emerged as a new method tumor treatment. Herein, we manufactured ultrasmall dopamine-modified hyaluronic acid (HD)-stabilized Fe(III)-tannic nanoparticles (HFTNPs). HFTNPs can accumulate inflammatory...
Both white matter hyperintensities (WMHs) and lacunar infarctions (LIs) are magnetic resonance imaging (MRI) markers of cerebral small vessel disease (SVD). However, the association between WMH LI remains unclear. In this study, we asked whether progression is related to occurrence using retrospective data. Overall, 8475 patients with at least two MRI images were screened, 187 included in final study; 76 had (WL), 111 without (WOL). The divided into three groups according progression: Group...
Background: Cerebral small vessel disease (SVD) is a common cause of cognitive dysfunction. However, little known whether the altered reconfiguration pattern brain modular architecture regulates dysfunction in SVD. Methods: We recruited 25 cases SVD without impairment (SVD-NCI) and 24 with mild (SVD-MCI). According to Framingham Stroke Risk Profile, healthy controls (HC) were divided into 17 subjects (HC-low risk) 19 (HC-high risk). All individuals underwent resting-state functional magnetic...
Apathy is a common non-motor symptom in Parkinson's disease (PD), but little known about apathy and white matter (WM) change. In this study, we investigated whether fractional anisotropy (FA) of the WM can distinguish apathetic patients from non-apathetic PD patients, FA value correlates with severity PD.Thirty-nine participated our which 18 participants were symptom, 21 without symptom. Diffusion tensor imaging was performed on all subjects.Compared to group had reduced values genu body...
Mild cognitive impairment (MCI) is a heterogeneous entity that can be categorized into related but different subtypes. In this study, we analyzed the gray matter structural changes of amnestic MCI (aMCI) and non-amnestic (naMCI), how it resulted in diverse impairment.Altogether 77 individuals were recruited, including 28 cognitively normal controls (NC), 25 naMCI subjects, 24 aMCI subjects. All participants underwent 3.0 T magnetic resonance (MR) scan detailed neuropsychological examination....
High cognitive reserve (CR) protects against decline in individuals with white matter hyperintensities (WMH). However, the functional mechanisms remain relatively unknown. This work aimed to explore effects of CR on frontoparietal control network (FPCN) and function subjects WMH. One hundred thirty-seven WMH 95 without underwent neuropsychological testing, assessments, multimodal magnetic resonance imaging (MRI) scanning. A mixed analysis covariance level (high vs. low CR) status (with WMH)...