A5089505260- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Disease Mechanisms and Treatments
- Image and Signal Denoising Methods
- Gastric Cancer Management and Outcomes
- Urinary and Genital Oncology Studies
- Sexual function and dysfunction studies
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Circular RNAs in diseases
- Advanced Data Compression Techniques
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
Nanjing Drum Tower Hospital
2020-2024
Guangxi University
2024
Wuxi People's Hospital
2022-2024
Xian Yang Central Hospital
2022-2024
Jiangnan University
2023-2024
Huazhong University of Science and Technology
2024
Chongqing Medical University
2021-2023
Jilin Province Tumor Hospital
2023
Wuxi No.2 People's Hospital
2023
Beijing University of Civil Engineering and Architecture
2023
Abstract Purpose: We established a CT-derived approach to achieve accurate progression-free survival (PFS) prediction EGFR tyrosine kinase inhibitors (TKI) therapy in multicenter, stage IV EGFR-mutated non–small cell lung cancer (NSCLC) patients. Experimental Design: A total of 1,032 CT-based phenotypic characteristics were extracted according the intensity, shape, and texture NSCLC pretherapy images. On basis these CT features from 117 EGFR-mutant patients, signature was proposed using Cox...
Clinically, it is difficult to differentiate the early stage of malignant melanoma and certain benign skin lesions due similarity in appearance. Our research uses image analysis clinical images relative color-based pattern recognition techniques enhance improve differentiation these lesions.
OBJECTIVES: To analyze the distant metastasis possibility based on computed tomography (CT) radiomic features in patients with lung cancer. METHODS: This was a retrospective analysis of 348 cancer enrolled between 2014 and February 2015. A feature set containing clinical 485 extracted from pretherapy CT images. Feature selection via concave minimization (FSV) used to select effective features. support vector machine (SVM) evaluate predictive ability each feature. RESULTS: Four three were...
18-fluorodeoxyglucose positron emission tomography/computed tomography (
Background: Lung nodules are being detected at an increasing rate year by with high-resolution computed tomography (HRCT) widely used. Ground-glass opacity nodule is one of the special types pulmonary that confirmed to be closely associated early stage lung cancer. Very little known about solitary ground-glass (SGGNs). In this study, we analyzed clinical, pathological, and radiological characteristics SGGNs on HRCT. Methods: A total 95 resected were evaluated HRCT scan. The these cases...
Glioblastoma (GBM) is the most common and lethal primary brain tumor characterized by extensive vascularization. Anti-angiogenic therapy for this cancer offers possibility of universal efficacy. However, preclinical clinical studies suggest that anti-VEGF drugs, such as Bevacizumab, actively promote invasion, which ultimately leads to a therapy-resistant recurrent phenotype GBMs. Whether Bevacizumab can improve survival over chemotherapy alone remains debated. Herein, we emphasize importance...
Background The role of brain atrophy in cognitive decline related to cerebral small vessel disease (CSVD) remains unclear. This study used AccuBrain™ identify major CSVD-related changes and verified the relationship between different cognition domains CSVD patients. Methods All enrolled 242 patients 76 healthy participants underwent magnetic resonance imaging examinations detailed neuropsychological scale assessments were collected at same time. technology was applied fully automated image...
High cognitive reserve (CR) protects against decline in individuals with white matter hyperintensities (WMH). However, the functional mechanisms remain relatively unknown. This work aimed to explore effects of CR on frontoparietal control network (FPCN) and function subjects WMH. One hundred thirty-seven WMH 95 without underwent neuropsychological testing, assessments, multimodal magnetic resonance imaging (MRI) scanning. A mixed analysis covariance level (high vs. low CR) status (with WMH)...
This study aimed to analyze the potential association between cognition reserve (CR) components, including education, working activity, and leisure time cognitive function in subjects with white matter hyperintensities (WMH). The also explored role of frontoparietal control network (FPCN) such association.
Abstract Glioma, particularly glioblastomas (GBM), is incurable brain tumor. The most targeted receptor tyrosine kinase (RTKs) drugs did not bring benefit to GBM patients. mechanism of glioma growth continues be explored find more effective treatment. Here, we reported that Ser/Thr protein YANK2 (yet another 2) upregulated in tissues and promotes the proliferation vitro vivo. Further, confirmed oncogene Fyn directly activated through phosphorylation its Y110, Fyn-mediated at Y110 site by...
Although white matter hyperintensity (WMH) is closely associated with cognitive decline, the precise neurobiological mechanisms underlying this relationship are not fully elucidated. Connectome studies have identified a primary-to-transmodal gradient in functional brain networks that support spectrum from sensation to cognition. However, whether connectome structure altered as WMH progresses and how alteration WMH-related decline remain unknown.
Abstract Aims We aimed to determine whether preprocedural renal function affects the outcome of acute ischemic stroke (AIS) patients with mechanical thrombectomy (MT) and this effect is modified by onset‐to‐reperfusion time (OTR) mediated collateral status. Methods Eligible anterior circulation large vessel occlusion (LVO) who underwent MT between August 2018 2020 were reviewed. The main was good functional [defined as Rankin Scale (mRS) 0–2] at 3 months. Multivariable logistic regression...
Purpose Combined the number, volume, and location of cerebral microbleeds (CMBs), this study aimed to explore different features CMBs their correlation with cognitive ability in patients type 2 diabetes mellitus (T2DM). Methods This recruited 95 T2DM 80 healthy control (HC) individuals. AccuBrain ® , an automated tool, was used obtain number volume CMBs. The scores on global cognition five domains were derived from a battery tests. logistic regression multivariate linear conducted determine...
Atopic dermatitis (AD) is a common skin disorder with elevated prevalence. Cataract induced by AD rarely occurs in adolescent and young adult patients, which also called atopic cataract. Using whole exome sequencing, we aimed to explore genetic alterations among cataract.We recruited 19 year-old Chinese male accompanied cataracts, his father mother without or Through analysis of the exomic sequence 3 individuals from same family, identified that respect AD, there were 162 genes mutated both...