A5102002270- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Lung Cancer Research Studies
- T-cell and B-cell Immunology
- PI3K/AKT/mTOR signaling in cancer
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Long-Term Effects of COVID-19
- Cancer Genomics and Diagnostics
- Climate Change and Health Impacts
- Cancer-related gene regulation
- Thermal Regulation in Medicine
- Protein Kinase Regulation and GTPase Signaling
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- RNA and protein synthesis mechanisms
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Global Health Care Issues
Fudan University
2025
Zhongshan Hospital
2025
Shuguang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2025
Sichuan University
2014-2023
West China Hospital of Sichuan University
2014-2023
Northeast Forestry University
2023
University Hospital Regensburg
2021
West China Medical Center of Sichuan University
2020-2021
First Affiliated Hospital of Fujian Medical University
2020
Epidermal growth factor receptor (EGFR) genotype is crucial for treatment decision making in lung cancer, but it can be affected by tumour heterogeneity and invasive biopsy during gene sequencing. Importantly, not all patients with an EGFR mutation have good prognosis EGFR-tyrosine kinase inhibitors (TKIs), indicating the necessity of stratifying EGFR-mutant genotype. In this study, we proposed a fully automated artificial intelligence system (FAIS) that mines whole-lung information from CT...
Management of persistent inflammation, immunosuppression, and catabolism syndrome (PICS) after sepsis remains challenging for patients in the intensive care unit, experiencing poor quality life death. However, immune-cell signatures with PICS remain unclear. We determined at single-cell resolution. Murine cecal ligation puncture models were applied validation. Immune functions two enriched monocyte subpopulations, Mono1 Mono4, suppressed substantially partially restored exhibited...
Background Glycogen synthase kinase 3 beta (GSK3β) is centrally involved in diverse cellular processes, including proliferation and apoptosis. This study aimed to investigate the influence of GSK3β expression on prognosis human non-small cell lung cancer (NSCLC) effects inhibition NSCLC lines. Methods Immunohistochemical western blot assays were used evaluate level tissues. Lentiviral RNA interference was performed inhibit A549, H292, H1299 SK-MES-1 Cell survival, apoptosis motility...
Ribosomal protein S6 (rpS6), a component of the 40S ribosomal subunit, is involved in multiple cellular bioactivities. However, its clinicopathological significance non-small cell lung cancer (NSCLC) poorly understood. Expressions total rpS6 (t-rpS6) and phosphorylated (Ser235/236, p-rpS6) were detected immunohistochemically 316 NSCLC tissues 82 adjacent controls, followed by statistical evaluation relationship between proteins expressions patients' survivals to identify their prognostic...
The roles of carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA21-1) and neuron-specific enolase (NSE) in metastases occurrence poor diagnosis specific histological classifications lung cancer need further exploring. In this study, we investigated relationship between elevated levels three biomarkers CEA, CYFRA21-1 NSE (individually combination) metastasis, survival status prognosis patients. Eight hundred sixty eight patients including adenocarcinoma (ADC, N = 445), squamous...
The COVID-19 outbreak is becoming a public health emergency. Data are limited on the clinical characteristics and causes of death. A retrospective analysis deaths were performed for patients' characteristics, laboratory results, In total, 56 patients (72.7%) decedents (male–female ratio 51:26, mean age 71 ± 13, survival time 17.4 8.4 days) had comorbidities. Acute respiratory failure (ARF) sepsis main Increases in C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer lactic acid...
Background As a serine/threonine protein kinase, p70S6K plays an important role in tumor cells. Evidence has revealed overexpression of and phosphorylated (p-p70S6K) various tissues, with these proteins identified as independent prognostic markers non-small cell lung cancer (NSCLC). In this study, we explored the specific inhibitor PF-4708671 NSCLC. Methods Three NSCLC lines (A549, SK-MES-1, NCI-H460) were treated at five different concentrations, including 0.1μM, 0.3μM, 1μM, 3μM 10μM,...
Background: Lung nodules are being detected at an increasing rate year by with high-resolution computed tomography (HRCT) widely used. Ground-glass opacity nodule is one of the special types pulmonary that confirmed to be closely associated early stage lung cancer. Very little known about solitary ground-glass (SGGNs). In this study, we analyzed clinical, pathological, and radiological characteristics SGGNs on HRCT. Methods: A total 95 resected were evaluated HRCT scan. The these cases...
Lymphoepithelioma-like carcinoma (LELC) is a rare subtype of non-small cell lung cancer (NSCLC). No clinical trials have been performed, and no course treatment for LELC has established because it's rarity. This study presents patient with primary pulmonary LELC, who was treated nivolumab, responded favorably.A using nivolumab.The well to immunotherapy nivolumab. After five cycles the size tumor lesions liver became smaller. A blood test showed that CYFRA21-1 NSE had dramatically decreased...
Pregnancy complicated with tuberculosis is increasingly common. The clinical characteristics of pregnancy miliary are summarized in this study.
Mesenchymal stem cells (MSCs) have been applied to cell-based therapy due their multiple differentiation ability, the low expression of co-stimulatory molecules and immunosuppressive properties. Despite immunomodulatory role, issue survival permanence MSCs at site injury has not yet fully resolved. Therefore, in order improve therapeutic potential MSCs, it is important study mechanisms mediating relative instability clinical trials. The Toll-like receptors (TLRs) are an component innate...