A5101663376- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Cognitive and developmental aspects of mathematical skills
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Tryptophan and brain disorders
- Reading and Literacy Development
- Mathematics Education and Teaching Techniques
- Neural and Behavioral Psychology Studies
- Neuroendocrine regulation and behavior
- Traditional Chinese Medicine Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Olfactory and Sensory Function Studies
- Action Observation and Synchronization
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Neuroscience, Education and Cognitive Function
Nanjing Drum Tower Hospital
2016-2025
Jiangsu Province Blood Center
2016-2025
Nanjing University
2013-2025
Nanjing Medical University
2011-2025
Nanjing University of Chinese Medicine
2025
First Affiliated Hospital of Kunming Medical University
2025
McMaster University
2013-2024
Population Health Research Institute
2024
First Affiliated Hospital of Zhengzhou University
2024
Chinese Institute for Brain Research
2018-2023
The neural mechanism for selectively tuning in to a target speaker while out the others multi-speaker situation (i.e., cocktail-party effect) remains elusive. Here we addressed this issue by measuring brain activity simultaneously from listener and multiple speakers they were involved naturalistic conversations. Results consistently show enhanced interpersonal synchronization (INS) between attended at left temporal-parietal junction, compared with that unattended across different situations....
Abstract The neural mechanism for the dyadic process of teaching is poorly understood. Although theories about have proposed that before any takes place, teacher will predict knowledge state student(s) to enhance outcome, this theoretical Prediction‐Transmission hypothesis has not been tested with neuroimaging studies. Using functional near‐infrared spectroscopy‐based hyperscanning, study measured brain activities teacher–student pairs simultaneously. Results showed better outcome was...
Studies have shown that female children, on average, consistently outperform male children in arithmetic. In the research reported here, 1,556 pupils (8 to 11 years of age) from urban and rural regions greater Beijing area completed 10 cognitive tasks. Results showed girls outperformed boys arithmetic tasks (i.e., simple subtraction, complex multiplication), as well numerosity-comparison, number-comparison, number-series-completion, choice reaction time, word-rhyming Boys a mental rotation...
Subjective cognitive decline (SCD) is a preclinical stage along the Alzheimer's disease (AD) continuum. However, little known about aberrant patterns of connectivity and topological alterations brain functional connectome their diagnostic value in SCD.
Background: Immune system activation is frequently reported in patients with Alzheimer's disease (AD). However, it remains unknown whether this a cause, consequence, or an epiphenomenon of brain degeneration. Objective: The present study examine
Abstract Mathematical disabilities ( MD ) have a negative life‐long impact on professional success, employment, and health outcomes. Yet little is known about the intrinsic functional brain organization that contributes to poor math skills in affected children. It now increasingly recognized cognition requires coordinated interaction within large‐scale fronto‐parietal network anchored intraparietal sulcus IPS ). Here we characterize connectivity this ‐network children with , relative group...
Deep gray matter structures are associated with memory and other important functions that impaired in Alzheimer's disease (AD) mild cognitive impairment (MCI). However, systematic characterization of the subregional atrophy deformations these AD MCI still need more investigations. In this article, we combined complex volumetry- vertex-based analysis to investigate pattern structural alterations deep its association global clinical scores (n = 30) patients 30), compared normal controls (NCs,...
Socioeconomic status (SES) disparities have profound impacts on child development and health, which are linked to negative emotions alterations in the integrity of stress-sensitive hypothalamus-pituitary-adrenal (HPA)-axis system. However, its underlying psychophysiological mechanisms remain poorly understood. Here we investigate how family SES, concert with parental anxiety, affects children’s anxiety their HPA-axis system two studies involving a total 1318 children parents. In Study 1...
Background and Objective: Subjective cognitive decline (SCD) is considered a preclinical state of Alzheimer's disease (AD) may represent more advanced status than amnestic mild impairment (aMCI). Our aim was to explore changes in the white matter (WM) microstructure their correlation with function these AD-spectrum patients. Methods: Diffusion tensor images from 43 individuals normal cognition (NC), 38 SCD patients, 36 aMCI patients were compared using an atlas-based segmentation strategy....
Abstract Human beings organise socially. Theories have posited that interpersonal neural synchronisation might underlie the creation of affiliative bonds. Previous studies tested this hypothesis mainly during a social interaction, making it difficult to determine whether identified is associated with bonding or interaction. This study addressed issue by focusing on teacher–student relationship in resting state both before and after teaching period. Brain activity was simultaneously measured...
Abstract Interpersonal touch plays a key role in creating and maintaining affiliative pair bonds romantic love. However, the neurocognitive mechanism of interpersonal bonding remains unclear. Here, we hypothesized that neural synchronization (INS) during underlies between couples. To test this hypothesis, INS heterosexual couples opposite-sex friends was measured using functional near-infrared spectroscopy-based hyperscanning, while pairs participants touched or vocally communicated with...
Abstract Introduction Neuro‐navigated repetitive transcranial magnetic stimulation (rTMS) is effective in alleviating cognitive deficits Alzheimer's disease (AD). However, the strategy for target determination and mechanisms improvement remain unclear. Methods One hundred thirteen elderly subjects were recruited this study, including both cross‐sectional ( n = 79) longitudinal experiments (the rTMS group: 24; sham 10). The experiment explored precise intervention based on...
Brain white matter fiber bundles in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) have abnormalities not usually seen unaffected subjects. Ideal algorithm of the localization-specific properties integrity might reveal changes tissue varying along each tract, while previous studies only detected mean DTI parameters fiber. The aim this study was to investigate whether these nerve tracts are localized specific regions or spread throughout analyze which examined...
Abstract The default mode network (DMN) is a workspace for convergence of internal and external information. frontal parietal (FPN) indispensable to executive functioning. Yet, how they interplay support cognitive development remains elusive. Using longitudinal developmental fMRI with an n-back paradigm, we show heterogeneity maturational changes in multivoxel activity connectivity among DMN FPN nodes 528 children 103 young adults. Compared adults, exhibited prominent improvement but still...
Background:Lacunar infarctions (LI) have been associated with a cognitive decline and an increased risk of dementia. Whether how the pattern spontaneous brain activity in patients mild impairment (MCI) differs subjects without concomitant LI remains unclear. Object ive:To compare MCI versus those using resting-state functional magnetic resonance imaging (rs-fMRI). Methods:Forty-eight patients, including 22 [MCI-LI] 26 [MCI-no LI], 28 normal underwent rs-fMRI post-processed regional...
Previous studies on dual-brain social interaction have shown different patterns of interpersonal neural synchronization (INS) between conflictual and supportive interactions, but the role emotion in mechanisms such interactions is not well understood. Furthermore, little known about how are affected by relationship type (e.g., romantic vs. friendship) mode verbal nonverbal). To elaborate these issues, this study used functional near-infrared spectroscopy to collect hemodynamic signals from...
Retinal imaging being a potential biomarker for Alzheimer's disease is gradually attracting the attention of researchers. However, association between retinal parameters and AD neuroimaging biomarkers, particularly structural changes, still unclear. In this cross-sectional study, we recruited 25 cognitively impaired (CI) 21 normal (CN) individuals. All subjects underwent layer thickness microvascular measurements with optical coherence tomography angiography (OCTA). Gray matter white (WM)...
Atrophy of the cortical thickness and gray matter volume are regarded as sensitive markers for early clinical diagnosis Alzheimer's disease (AD). This study aimed to investigate differences in atrophy patterns frontal-subcortical circuits between MCI AD, assess whether these were essential pathologic basis cognitive impairment. A total 131 individuals recruited, including 45 with cognitively normal controls (CN), 46 MCI, 40 AD. FreeSurfer software was used perform volumetric measurements...