A5100602378- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Medical Image Segmentation Techniques
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Scoliosis diagnosis and treatment
- Acute Ischemic Stroke Management
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Attachment and Relationship Dynamics
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
- Brain Tumor Detection and Classification
- Cardiovascular Health and Disease Prevention
- Family Dynamics and Relationships
- Intracerebral and Subarachnoid Hemorrhage Research
- Topic Modeling
- Stroke Rehabilitation and Recovery
- Epilepsy research and treatment
- Medical Imaging Techniques and Applications
Chinese University of Hong Kong
2016-2025
State Forestry and Grassland Administration
2025
Ningbo No. 2 Hospital
2023-2025
Shandong Eye Hospital
2025
Shandong First Medical University
2023-2025
Kyushu Institute of Technology
2022-2025
Kyushu Art Institute of Technology
2025
Shanghai Sixth People's Hospital
2024
Dalian Medical University
2023-2024
First Affiliated Hospital of Dalian Medical University
2023-2024
Cerebral microbleeds (CMBs) are small haemorrhages nearby blood vessels. They have been recognized as important diagnostic biomarkers for many cerebrovascular diseases and cognitive dysfunctions. In current clinical routine, CMBs manually labelled by radiologists but this procedure is laborious, time-consuming, error prone. paper, we propose a novel automatic method to detect from magnetic resonance (MR) images exploiting the 3D convolutional neural network (CNN). Compared with previous...
Acute ischemic stroke is recognized as a common cerebral vascular disease in aging people. Accurate diagnosis and timely treatment can effectively improve the blood supply of area reduce risk disability or even death. Understanding location size infarcts plays critical role decision. However, manual localization quantification lesions are laborious time-consuming. In this paper, we propose novel automatic method to segment acute from diffusion weighted images (DWIs) using deep 3-D...
Distal radius fracture is common in the general population. Fracture management includes a plaster cast, splint and synthetic material cast to immobilise injured arm. Casting complications are those conventional casting technologies. 3D printing technology rapidly increasing application rehabilitation. However, there no clinical study investigating of 3D–printed orthopaedic for treatment bone fractures. We have developed patient-specific fabricated by printing. This pioneering aims use casts...
Lesion location is an important determinant for post-stroke cognitive impairment. Although several ‘strategic’ brain regions have previously been identified, a comprehensive map of strategic impairment lacking due to limitations in sample size and methodology. We aimed determine by applying multivariate lesion-symptom mapping large cohort 410 acute ischemic stroke patients. Montreal Cognitive Assessment at three six months after was used assess global functioning domains (memory, language,...
Two point four out of 100 people suffer from one or more fractures in the course average lifetimes. Traditional casts are featured as cumbersome structures that result high risk cutaneous complications. Clinical demands for developing a hygienic cast have gotten and attention. 3D printing technique is rapidly growing fabrication custom-made rehabilitation tools. The objective this study to develop rapid intelligent modeling patient-specific orthopedic produced by technologies. A model...
Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue dysfunction. This study reports minimally invasive convenient approach obtaining scarless using silk fibroin microneedle patch (SF MNs). We found that by tuning the MN size density only, biocompatible MNs significantly decreased elevation index in rabbit ear model increased ultimate tensile strength close...
Abstract Using both quantitative and qualitative methods, this study contrasted employees' job stress perceptions their relationships to strains in China the United States. Significant stressor–strain correlations were found countries. However, hierarchical regression analyses revealed significant interactions of country by stressors predicting strains, indicating unique patterns In analyses, American employees reported significantly more incidents lack control, direct interpersonal...
We reported a simple polydopamine (PDA)-based surface modification method to prepare novel targeted doxorubicin-loaded mesoporous silica nanoparticles and peptide CSNRDARRC conjugation (DOX-loaded MSNs@PDA-PEP) for enhancing the therapeutic effects on bladder cancer. Drug-loaded NPs were characterized in terms of size, size distribution, zeta potential, transmission electron microscopy (TEM), Brunauer–Emmett–Teller (BET) area drug loading content. In vitro release indicated that DOX-loaded...
Radiomics-based researches have shown predictive abilities with machine-learning approaches. However, it is still unknown whether different radiomics strategies affect the prediction performance. The aim of this study was to compare performance frequently utilized feature selection and classification methods in glioma grading. Quantitative features were extracted from tumor regions 210 Glioblastoma (GBM) 75 low-grade (LGG) MRI subjects. Then, diagnostic sixteen fifteen evaluated by using two...
Intensity normalization is an important preprocessing step in brain magnetic resonance image (MRI) analysis. During MR acquisition, different scanners or parameters would be used for scanning subjects the same subject at a time, which may result large intensity variations. This variation will greatly undermine performance of subsequent MRI processing and population analysis, such as registration, segmentation, tissue volume measurement. In this work, we proposed new histogram method to...
Newtonian fluid model has been commonly applied in simulating cerebral blood flow intracranial atherosclerotic stenosis (ICAS) cases using computational dynamics (CFD) modeling, while is a shear-thinning non-Newtonian fluid. We aimed to investigate the differences of hemodynamic metrics quantified CFD models built with and assumptions, patients ICAS.We virtual artery an eccentric 75% performed static simulation. also constructed three ICAS different severities luminal stenosis. simulations...
Olfactory impairment is a potential marker for prodromal dementia, but the underlying mechanisms are poorly understood. This population-based study included 4214 dementia-free participants (age ≥65 years). Olfaction was assessed using 16-item Sniffin' Sticks identification test. In subsamples, we measured plasma amyloid beta (Aβ)40, Aβ42, total tau, and neurofilament light chain (NfL; n = 1054); quantified hippocampal, entorhinal cortex, white matter hyperintensity (WMH) volumes, Alzheimer's...
Soft robotic technologies are attracting significant attention since they can realize delicate tasks that traditional stiff robots cannot. Two-dimensional transition metal carbide/nitride, known as MXene, endow soft materials with important properties, including adjustable electrical conductivity, high mechanical stability, and versatile responsiveness, making it an attractive material for systems. In this review, we present a systematic summary of recent applications MXenes in The...
In a prospective longitudinal study with 218 Parkinson's disease (PD) patients in the discovery cohort and 84 validation cohort, we aimed to identify novel blood biomarkers predicting disability milestones PD. Through Least Absolute Shrinkage Selection Operator-Cox (Lasso-Cox) regression, developed nomogram predictive model Linear mixed-effects models, identified low level of plasma fibronectin (pFN) as one best-performing risk markers milestones. A pFN was associated short milestone-free...
This study examined whether adult attachment was predictive of conflict resolution behaviors and satisfaction in romantic relationships. It adopted a two-dimensional conceptualization for both style (model self, model others) (concern concern others). Both dimensions, Avoidance Anxiety, were relationship satisfaction. Gender differences existed behaviors, but they not as strong predictor characteristics No gender found styles.
Despite the known morphological differences (e.g., brain shape and size) in brains of populations different origins age race), Chinese atlas is less studied. In current study, we developed a statistical based on multi-center high quality magnetic resonance imaging (MRI) dataset 2020 adults (18-76 years old). We constructed 12 from 20 year to 75 at 5 interval. New standard space, coordinates, area labels were further defined. The new was validated registration segmentation. It found that, as...
Objective To compare the bone healing effects of denosumab and alendronate in female rheumatoid arthritis (RA) patients by high‐resolution peripheral quantitative computed tomography. Methods This is a post hoc analysis randomized controlled trial. Forty were 1:1 ratio to receive either subcutaneous (60 mg) once or oral (70 weekly for 6 months. The size individual erosions presence extent erosion‐associated sclerosis (marginal osteosclerosis) measured second metacarpal head nondominant hand...
Patients surviving stroke without immediate dementia are at high risk of delayed-onset dementia. Mechanisms underlying complex and may involve vascular and/or neurodegenerative diseases.Dementia-free patients with transient ischemic attack (TIA; n = 919) were studied for 3 years prospectively, excluding those who developed to 6 months after TIA.Forty subjects (4.4%) during the study period. Imaging markers severe small vessel disease (SVD), namely presence ≥3 lacunes confluent white matter...