White matter hyperintensity (WMH) is the most common neuroimaging manifestation of cerebral small vessel disease and related to cognitive dysfunction or dementia. This study aimed investigate mechanism effective indicators predict WMH-related impairment.We recruited 22 healthy controls (HC), 25 cases WMH with normal cognition (WMH-NC), 23 mild impairment (WMH-MCI). All individuals underwent diffusion tensor imaging (DTI) a standardized neuropsychological assessment. Automated Fiber...

The prevalence of white matter hyperintensities (WMH) rises dramatically with aging. Both the progression WMH and changing patterns default mode network (DMN) have been proven to be closely associated cognitive function. present study hypothesized that changes in functional connectivity structural DMN contributed related impairment. A total 116 subjects were enrolled from Cerebral Small Vessel Disease Register Drum Tower Hospital Nanjing University, distributed across three categories...

Background and Objective: Subjective cognitive decline (SCD) is considered a preclinical state of Alzheimer's disease (AD) may represent more advanced status than amnestic mild impairment (aMCI). Our aim was to explore changes in the white matter (WM) microstructure their correlation with function these AD-spectrum patients. Methods: Diffusion tensor images from 43 individuals normal cognition (NC), 38 SCD patients, 36 aMCI patients were compared using an atlas-based segmentation strategy....

Background Apolipoprotein E ( APOE ) ε4 is the most significant genetic risk factor for sporadic Alzheimer's disease (AD). However, its impact on dynamic changes in resting-state functional connectivity (FC), particularly concerning network formation, interaction, and dissolution over time, remains largely unexplored AD. Objective This study aims to explore effect of FC (dFC) variability cognitive performance Methods We analyzed dFC AD patients, comparing carriers (n = 33) with non-carriers...

Objective: To characterize earlier damage pattern of white matter (WM) microstructure in cerebral small vessel disease (CSVD) and its relationship with cognitive domain dysfunction. Methods: A total 144 CSVD patients 100 healthy controls who underwent neuropsychological measurements diffusion tensor imaging (DTI) examination were recruited. Cognitive function, emotion, gait assessed each participant. The automated fiber quantification (AFQ) technique was used to extract different properties...

Glymphatic dysfunction has been linked to cognitive decline in several neurodegenerative diseases. In cerebral small vessel disease (CSVD), the mechanism of white matter hyperintensities (WMH)-related impairment (CI) is still under investigation. The diffusion tensor image (DTI) analysis along perivascular space (ALPS) method considered be a reliable parameter evaluate glymphatic function. Therefore, we applied ALPS-index determine influence function on CI CSVD. total, 137 CSVD patients...

Abstract Functional changes of default mode network (DMN) have been proven to be closely associated with white matter hyperintensity (WMH) related cognitive impairment (CI). However, subsystem mechanisms DMN underlying WMH‐related CI remain unclear. The present study recruited WMH patients ( n = 206) mild and normal cognition, as well healthy controls (HC, 102). Static/dynamic functional connectivity (FC) the DMN's three subsystems were calculated using resting‐state MRI. K‐means clustering...

Gait disorder (GD) is a common problem in cerebral small vessel disease (CSVD). This study aimed to determine (1) the early characteristics of GD CSVD, (2) cerebellar neuroimaging features related and (3) association cognitive impairment with GD.

Abstract Purpose To identify the volume changes of hippocampus subfields in T2DM patients with cognitive impairment and to determine how these atrophy patterns associate impairments different domain. Methods A total 117 individuals were recruited, including (T2DM-CI) ( n = 34), without (T2DM-non-CI) 36) normal controls (NC) 47). All subjects went through a 3.0 T magnetic resonance (MR) scan neuropsychological assessment. Hippocampal subfield volumes processed using FreeSurfer 6.0.0 compared...

White matter hyperintensity (WMH) is widely observed in the elderly population and serves as a key indicator of cognitive impairment (CI). However, underlying mechanism remains to be elucidated. Herein, we investigated topological patterns resting state functional networks WMH subjects relationship between measures CI. A graph theory-based analysis was employed resting-state magnetic resonance scans 112 (38 with without dementia (CIND), 36 normal cognition 38 healthy controls (HCs), found...

Background Impaired cerebrovascular reactivity (CVR) plays an important role in the pathophysiology of white matter hyperintensities (WMHs). The pathogenesis CVR development WMH‐related cognitive impairment (CI) remains poorly understood. Purpose To detect status WMH subjects with/without CI by using a resting‐state blood oxygenation level‐dependent (BOLD) approach and to explore mediating relationships among CVR, WMH, level. Study Type Prospective. Subjects with moderate severe (with...

White matter hyperintensities (WMHs) are associated with higher anxiety or depression (A/D) incidence. We investigated associations of WMHs A/D, cerebrovascular reactivity (CVR), and functional connectivity (FC) to identify potential pathomechanisms. Participants WMH (n = 239) normal controls (NCs, n 327) were assessed for A/D using the Hamilton Anxiety Rating Scale (HAMA) Depression (HAMD). The CVR FC maps constructed from resting-state MRI. Two-way analysis covariance fixed factors was...

Cognitive decline progresses with age, and Nr4a1 has been shown to participate in memory functions. However, the relationship between age-related reduction cognitive is undefined.

The BOLD signal is regulated by neuronal activity and vascular physiology. evolution pattern of brain activities after modulating the factors in white matter hyperintensities (WMHs) related cognitive impairment (CI) was unknown.To explore "pure" low-frequency fluctuation (ALFF) alterations adjusting cerebrovascular reactivity (CVR) factor.In this study, 111 WMHs subjects including 55 with CI (WMH-CI) 56 without (WMH-no-CI), 72 normal controls (NCs) underwent resting-state fMRI. CVR ALFF maps...

This study aimed to investigate the relationships of impaired cerebrovascular reactivity (CVR) and abnormal functional connectivity (FC) with white matter hyperintensity (WMH)-related cognitive decline. A total 233 WMH subjects were recruited categorized into WMH-I (n = 106), WMH-II 72), WMH-III 55) groups according Fazekas visual rating scale. All participants underwent neuropsychological tests multimodal MRI scans, including 3D-T1, resting-state magnetic resonance imaging (rs-fMRI). The...

White matter hyperintensities (WMH) is an important cause of vascular cognitive impairment (CI). However, a considerable portion individuals with WMH do not develop CI. The present study aimed to investigate distinctive regional brain activity and connectivity patterns in subjects without CI, who displayed comparable burden. Fourteen 16 CI 37 healthy underwent multimodal MRI scans neuropsychological tests. All Fazekas grade 2 WMH. Regional Homogeneity (ReHo) functional (FC) were identified...

Purpose: There is a high correlation between white matter hyperintensity (WMH) and cognitive impairment (CI) in elderly people. However, not all WMH subjects will develop into CI the potential mechanism of related still unclear. This study aimed to investigate topological properties structural network CI. Methods: 41 with (WMH-CI), 42 without (WMH-no-CI) 52 healthy controls (HC) were recruited. Diffusion tensor imaging (DTI) fiber tractography graph theoretical analysis applied construct...

Depression is a common comorbid symptom in patients with chronic insomnia disorder (CID). Previous neuroimaging studies found that the orbital frontal cortex (OFC) might be core brain region linking and depression. Here, we used machine learning approach to differentiate CID depressive symptoms from without based on OFC functional connectivity. Seventy were recruited subdivided into high (CID-HD) low (CID-LD) groups. The connectivity (FC) network was constructed using altered structure of as...

Aims The present study aims to investigate the mutation spectrum of thalassaemia, and characterise erythrocyte indices thalassaemia in a large cohort Sichuan, which is province with high prevalence southern China. Methods was conducted from July 2017 2019. A total 42 155 women screened for were enrolled. carriers by analysis haemoglobin electrophoresis. Then, screening test results genetic collected. Results 1109 individuals had gene defects. Among these individuals, 69.7% α-thalassaemia...

The mechanism of gait and balance dysfunction (GBD) in cerebral small vessel disease (CSVD) remains unclear. Evidence supports cognition engages GBD CSVD. cerebellum is important motor cognition, while little known about the influence on This study a retrospective cohort study. All participants this were enrolled from CSVD individuals Nanjing Drum Tower Hospital 2017 to 2021. patients was defined as Tinetti Test score ≤ 23. Cerebral cortical thickness, cerebellar gray matter volume,...

Although white matter hyperintensity (WMH) is closely associated with cognitive decline, the precise neurobiological mechanisms underlying this relationship are not fully elucidated. Connectome studies have identified a primary-to-transmodal gradient in functional brain networks that support spectrum from sensation to cognition. However, whether connectome structure altered as WMH progresses and how alteration WMH-related decline remain unknown.

Background: The degenerative pattern of white matter (WM) microstructures during Alzheimer's disease (AD) and its relationship with cognitive function have not yet been clarified. present research aimed to explore the alterations WM microstructure impact on amnestic mild (aMCI) AD patients. Mechanical learning methods were used validity lesions classification in spectrum disease. Methods: Neuropsychological data diffusion tensor imaging (DTI) images collected from 28 subjects, 31 aMCI 27...