A5100410690- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- RNA modifications and cancer
- RNA Research and Splicing
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Genetic factors in colorectal cancer
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Cancer, Hypoxia, and Metabolism
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
- ECG Monitoring and Analysis
- Head and Neck Surgical Oncology
University of Science and Technology of China
2015-2025
Anhui Jianzhu University
2025
Jinan University
2025
Anhui Medical University
2019-2025
First Affiliated Hospital of Anhui Medical University
2019-2025
Hefei National Center for Physical Sciences at Nanoscale
2019-2024
Tangshan Gongren Hospital
2022-2024
Hebei Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Sound-including music and noise-can relieve pain in humans, but the underlying neural mechanisms remain unknown. We discovered that analgesic effects of sound depended on a low (5-decibel) signal-to-noise ratio (SNR) relative to ambient noise mice. Viral tracing, microendoscopic calcium imaging, multitetrode recordings freely moving mice showed low-SNR sounds inhibited glutamatergic inputs from auditory cortex (ACxGlu) thalamic posterior (PO) ventral (VP) nuclei. Optogenetic or chemogenetic...
Abstract Anxiety-associated symptoms following acute stress usually become extinct gradually within a period of time. However, the mechanisms underlying how individuals cope with to achieve extinction anxiety are not clear. Here we show that restraint causes an increase in activity GABAergic neurons CeA (GABA ) male mice, resulting anxiety-like behaviors 12 hours; meanwhile, elevated GABA neuronal CX3CL1 secretion via MST4 (mammalian sterile-20-like kinase 4)-NF-κB-CX3CL1 signaling...
Prosocial behaviors are advantageous to social species, but the neural mechanism(s) through which others receive benefit remain unknown. Here, we found that bystander mice display rescue-like behavior (tongue dragging) toward anesthetized cagemates and this tongue dragging promotes arousal from anesthesia a direct tongue-brain circuit. We circuit → glutamatergic neurons in mesencephalic trigeminal nucleus (MTN Glu ) noradrenergic locus coeruleus (LC NE drives rapid bystanders. Artificial...
Chronic pain causes both physical suffering and comorbid mental symptoms such as anhedonia. However, the neural circuits molecular mechanisms underlying these maladaptive behaviors remain elusive. Here using a mouse model, we report pathway from vesicular glutamate transporter 3 neurons in dorsal raphe nucleus to dopamine ventral tegmental area (VGluT3DRN→DAVTA) wherein population-level activity response innocuous mechanical stimuli sucrose consumption is inhibited by chronic neuropathic...
Due to an altered expression of oncogenic factors and tumor suppressors, aggressive cancer cells have intrinsic or acquired resistance chemotherapeutic agents. This typically contributes recurrence after chemotherapy. microRNAs are short non-coding RNAs that involved in both cell self-renewal development. Here we report transfected with miR-378 properties cells. Overexpression enhanced survival colony formation, contributed multiple drug resistance. Higher concentrations drugs were needed...
Pain sensitization may contribute to pain severity in rheumatoid arthritis (RA), impacting disease activity assessment. We examined whether processing mechanisms were associated with among RA patients active disease.The study included 139 subjects enrolled the Central Rheumatoid Arthritis cohort. Subjects underwent quantitative sensory testing (QST), including assessment of pressure thresholds (PPTs) at multiple sites, conditioned modulation, and temporal summation. was assessed using...
Both the deregulation of microRNAs and epidermal growth factor receptor (EGFR) are emerging as important factors in non-small-cell lung cancer (NSCLC). Here, miR-133b was found to be associated with tumor stage, extent regional lymph node involvement, visceral pleura or vessel invasion EGFR mRNA expression Chinese patients NSCLC. Bioinformatic analysis luciferase reporter assay revealed that can interact specifically 3'-UTR mRNA. Functionally, transfection showed regulatory activity...
Neurotransmitters have been shown to regulate immune responses, and thereby are critically related autoimmune diseases. Here we showed that depletion of dopaminergic neurons significantly promoted activation hepatic iNKT cells augmented concanavalin A (Con A)-induced liver injury. The suppressive effect dopamine on was mediated by D1-like receptor-PKA pathway. Clearance gut microbiota antibiotic cocktail reduced synthesis in intestines exacerbated damage, could be restored recovery or...
Long non‐coding RNAs (lncRNAs) have been verified to modulate the tumorigenesis of breast cancer at multiple levels. In present study, we aim investigate role lncRNA FEZF1‐AS1 on cancer‐stem like cells (BCSC) and potential regulatory mechanism. tissue, was up‐regulated compared with controls indicated poor prognosis patients. vitro experiments, significantly over‐expressed in cells, especially sphere subpopulation parental subpopulation. Loss‐of‐functional that, BCSC (MDA‐MB‐231 CSC, MCF‐7...
Obsessive-compulsive disorder (OCD) affects ∼1 to 3% of the world's population. However, neural mechanisms underlying excessive checking symptoms in OCD are not fully understood. Using viral neuronal tracing mice, we found that glutamatergic neurons from basolateral amygdala (BLAGlu) project onto both medial prefrontal cortex glutamate (mPFCGlu) and GABA (mPFCGABA) locally innervate mPFCGlu neurons. Next, developed an mouse model with quinpirole-induced repetitive behaviors. This...
Brain capillaries are crucial for cognitive functions by supplying oxygen and other nutrients to removing metabolic wastes from the brain. Recent studies have demonstrated that constriction of brain is triggered beta-amyloid (Aβ) oligomers via endothelin-1 (ET1)-mediated action on ET1 receptor A (ETRA), potentially exacerbating Aβ plaque deposition, primary pathophysiology Alzheimer's disease (AD). However, direct evidence still lacking whether changes in causally involved AD. Using APP/PS1...
Abstract Mutations of the RAS oncogene are found in around 30% all human cancers yet direct targeting is still considered clinically impractical except for KRAS G12C mutant. Here we report that - ON (RASON), a novel protein encoded by long intergenic non-protein coding RNA 00673 ( LINC00673 ), positive regulator oncogenic signaling. RASON aberrantly overexpressed pancreatic ductal adenocarcinoma (PDAC) patients, and it promotes proliferation PDAC cell lines vitro tumor growth vivo....
Abstract Autoimmune uveitis (AU) is a kind of immune‐mediated disease resulting in irreversible ocular damage and even permanent vision loss. However, the precise mechanism underlying dynamic immune changes contributing to initiation progression AU remains unclear. Here, we induced an experimental (EAU) model with IRBP 651‐670 found that day[D]14 was inflammatory summit remarking clinical histopathological manifestations activation retinal microglia exhibited time‐dependent pattern EAU...
Anxiety is a remarkably common condition among patients with pharyngitis, but the relationship between these disorders has received little research attention, and underlying neural mechanisms remain unknown. Here, we show that densely innervated pharynx transmits signals induced by pharyngeal inflammation to glossopharyngeal vagal sensory neurons of nodose/jugular/petrosal (NJP) superganglia in mice. Specifically, NJP project norepinephrinergic nucleus solitary tract (NTS NE ). These NTS...