A5056785665- Functional Brain Connectivity Studies
- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Cerebrovascular and Carotid Artery Diseases
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Impact of Technology on Adolescents
- Dementia and Cognitive Impairment Research
- Fetal and Pediatric Neurological Disorders
- MRI in cancer diagnosis
- Autoimmune Bullous Skin Diseases
- Digital Mental Health Interventions
- Metabolomics and Mass Spectrometry Studies
- Neurological Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Renal and related cancers
- Neural dynamics and brain function
- MicroRNA in disease regulation
- Mathematical Biology Tumor Growth
- Parvovirus B19 Infection Studies
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
Beijing Friendship Hospital
2024
Capital Medical University
2022-2024
Shanghai Jiao Tong University
2013-2024
Renji Hospital
2018-2024
Beijing Tian Tan Hospital
2024
Ruijin Hospital
2024
Neurological Research Institute
2015-2023
Texas Children's Hospital
2015-2023
Baylor College of Medicine
2015-2023
International Peace Maternity & Child Health Hospital
2013-2022
Abstract BACKGROUND In the human fetus, sex chromosome aneuploidies (SCAs) are as prevalent common autosomal trisomies 21, 18, and 13. Currently, most noninvasive prenatal tests (NIPTs) offer screening only for chromosomes 13, because sensitivity specificity markedly higher than chromosomes. Limited studies suggest that reduced accuracy associated with detecting SCAs is due to confined placental, or true fetal mosaicism. We hypothesized an altered maternal karyotype may also be important...
Abstract Small extracellular vesicles (EVs), including exosomes, play multiple physiological roles. In neurodegenerative diseases, EVs can be pivotal in dispersing neuropathogenic proteins. This study investigates the role of neural stem cell (NSC)‐derived a transgenic (Tg) mouse model Alzheimer's disease (AD). Five weeks following treatment on 9‐month‐old APP/PS1 mice, effects NSC‐derived cognitive behavior, mitochondrial function, sirtuin1 (SIRT1), synaptic function and morphology,...
Cognitive behavior therapy (CBT) is effective for the treatment of Internet gaming disorder (IGD). However, mechanisms by which CBT improves IGD-related clinical symptoms remain unknown. This study aimed to discover therapeutic mechanism in IGD subjects using resting-state functional magnetic resonance imaging (rsfMRI). Twenty-six and 30 matched healthy controls (HCs) received rsfMRI scan assessments; 20 completed then were scanned again. The amplitude low-frequency (ALFF) values...
Abnormal reductions in cortical cerebral blood flow (CBF) have been identified subcortical vascular cognitive impairment (SVCI). However, little is known about the pattern of CBF reduction relation with degree impairment. measured 3D Arterial Spin Labeling (ASL) perfusion MRI helps detect functional changes subjects SVCI. We aimed to compare maps ischemic disease (SIVD) and without relationship regions brain according z-score. A total 53 SVCI 23 matched SIVD (controls) underwent a...
The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) their effects on cognition have rarely been investigated. We aimed to examine brain deposition svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we investigate the correlation between severity as indicated by z-scores. recruited 20 ischemic disease (SIVD) patients who fulfilled criteria for svMCI. control group comprised 19 SIVD without impairment. groups were...
Purpose To compare four methods of region‐of‐interest (ROI) placement for apparent diffusion coefficient (ADC) measurements in distinguishing low‐grade gliomas (LGGs) from high‐grade (HGGs). Materials and Methods Two independent readers measured ADC parameters using ROI (single‐slice [single‐round, five‐round freehand] whole‐volume) on 43 patients (20 LGGs, 23 HGGs) who had undergone 3.0 Tesla diffusion‐weighted imaging time required each method was recorded. Intraclass correlation...
Internet gaming disorder (IGD), a major behavior disorder, has increasing gained attention. Recent studies indicate altered resting-state static functional connectivity (FC) of the dorsolateral prefrontal cortex (DLPFC) in subjects with IGD. Whereas FC often provides information on changes IGD, investigations temporal between DLPFC and other brain regions may shed light dynamic characteristics function associated Thirty IGD thirty healthy controls (HCs) matched for age, gender education...
Pediatric intracranial space-occupying lesions are common, with prognoses improving markedly in recent years, significantly extending survival. As such, there is an imperative to pay increased attention the postoperative cognitive functions and brain network alterations these children because factors influence their quality of life. Temporal variability (TV) analysis networks captures full extent resting-state activities, reflecting rehabilitation potential. However, previous research rarely...
Purpose: To evaluate the feasibility of a simplified method based on diffusion-weighted imaging (DWI) acquired with three b-values to measure tissue perfusion linked microcirculation, validate it against from perfusion-related parameters derived intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging, investigate its utility differentiate low- high-grade gliomas. Materials Methods: The prospective study was approved by local institutional...
Normal-appearing white matter (NAWM) surrounding hyperintensities (WMHs), frequently known as the WMH penumbra, is associated with subtle injury and has a high risk for future conversion to WMHs. The goal of this study was define penumbras further explore whether diffusion perfusion parameters these could better reflect cognitive function alterations than WMHs in subjects subcortical vascular mild impairment (svMCI). Seventy-three svMCI underwent neuropsychological assessments 3T MRI scans,...
It has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences cravings. This study is to investigate the alterations in resting-state functional connectivity (rsFC) of dorsolateral prefrontal cortex (DLPFC) observed SND IGD. In this study, 27 IGD, 29 SND, 33 healthy controls (HC) underwent a magnetic resonance imaging (rs-fMRI) scan. DLPFC was determined all...
Herpes zoster infection, with its considerable burden to individuals and society, remains a challenge around the world. However, knowledge of authors, little bibliometric quantitative or qualitative analysis has been carried out evaluate herpes research. This study aimed use current publication trends hotspots on research worldwide, in order advance this field.Relevant publications from January 2012 December 2021 were collected Web Science Core Collection database. Citespace (V5.8.R3) was...
Deep learning has great potential for imaging classification by extracting low to high-level features. Our aim was train a convolutional neural network (CNN) with single T2-weighted FLAIR sequence classify different cognitive performances in patients subcortical ischemic vascular disease (SIVD). In total, 217 SIVD [including 52 dementia (VaD), 82 mild impairment (VaMCI), and 83 non-cognitive (NCI)] 46 matched healthy controls (HCs) underwent MRI scans neuropsychological assessments. 2D 3D...
Proton pump inhibitors (PPIs) are the mainstay of therapy for gastroesophageal reflux disease (GERD) but up to 60% patients have inadequate response therapy. Acid sensing ion channels (ASICs) play important roles in nociception. This study aimed investigate whether increased expression ASICs results neuronal hyperexcitability GERD. Esophageal biopsies were taken from GERD and healthy subjects compare ASIC1 3. Next, gene protein 3 esophageal mucosa dorsal root ganglia (DRG) neurons measured...
Converging lines of evidence indicates that smoking and internet gaming disorder (IGD) affect spontaneous brain activity, respectively. However, little is known about whether these two factors work together on the human brain. In this study, we investigated interaction between IGD local activity using amplitude low-frequency fluctuation (ALFF) based resting-state fMRI (rs-fMRI). Forty-six cigarette smokers, 38 individuals, 34 participants with both (IGD-Smoking), 60 healthy individuals...