A5021264172- Advanced Glycation End Products research
- Pain Mechanisms and Treatments
- Acute Lymphoblastic Leukemia research
- Inflammatory Bowel Disease
- Aquaculture disease management and microbiota
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Treatments and Mutations
- Chronic Kidney Disease and Diabetes
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Mangiferin and Mango Extracts
- Natural Antidiabetic Agents Studies
- PI3K/AKT/mTOR signaling in cancer
- Invertebrate Immune Response Mechanisms
- Microscopic Colitis
- Atherosclerosis and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Gastrointestinal Tumor Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Stress Responses and Cortisol
- Nutritional Studies and Diet
Chinese Academy of Fishery Sciences
2022-2025
University of Science and Technology of China
2019-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2017-2024
Sun Yat-sen University
2016-2024
Xuzhou Medical College
2014-2024
Hefei National Center for Physical Sciences at Nanoscale
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Gansu Agricultural University
2018
Air Force Medical University
2007-2015
Suzhou Municipal Hospital
2015
While comorbid pain in depression (CP) occurs at a high rate worldwide, the neural connections underlying core symptoms of CP have yet to be elucidated. Here, we define pathway whereby GABAergic neurons from central nucleus amygdala (GABACeA) project glutamatergic parafascicular (GluPF). These GluPF relay directly second somatosensory cortex (S2), well-known area involved signal processing. Enhanced inhibition GABACeA→GluPF→S2 is found mice exhibiting symptoms. Reversing this using...
The co-occurrence of diabetes and depression is a challenging underrecognized clinical problem. Alpha-carbonyl aldehydes their detoxifying enzyme glyoxalase 1 (Glo-1) play vital roles in the pathogenesis diabetic complications, including depression. Hesperidin, naturally occurring flavanone glycoside, possesses numerous pharmacological properties, but neuroprotection by hesperidin depression-like behaviors was not observed. This study aimed to investigate mechanisms signaling pathways which...
Anxiety is a remarkably common condition among patients with pharyngitis, but the relationship between these disorders has received little research attention, and underlying neural mechanisms remain unknown. Here, we show that densely innervated pharynx transmits signals induced by pharyngeal inflammation to glossopharyngeal vagal sensory neurons of nodose/jugular/petrosal (NJP) superganglia in mice. Specifically, NJP project norepinephrinergic nucleus solitary tract (NTS NE ). These NTS...
Abstract Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV), a natural polyphenolic compound, is known as promising anti-cancer agent. In this study, we showed that RSV could inhibit the growth of B16 cells via induction apoptosis. Moreover, our results for first time induced autophagy in cells, which might occur through ceramide accumulation and Akt/mTOR pathway inhibition. Inhibition by an autophagic inhibitor 3-methyladenine (3-MA) or si-Beclin 1 enhanced RSV-induced cytotoxicity Thus,...
One of the earliest critical secondary complications diabetes is opacification eye lens - a condition strictly associated with diabetic cataract. The study presented here was designed to investigate effect Ginkgo biloba extract (GbE), rutin and quercetin on streptozotocin (STZ) induced cataract (DC) rats. Ten weeks after administration GbE, quercetin, opacity rats' lenses graded under slit lamp. Then, levels malondialdehyde (MDA), reduced glutathione (GSH), advanced glycosylation end...
This study was designed to investigate the effects of mangiferin on renal fibrosis, osteopontin production, and inflammation in kidney diabetic rats. Diabetes induced through single administration streptozotocin (55 mg/kg, i.p.). Diabetic rats were treated with (15, 30, 60 mg/kg/day, i.g.) for 9 weeks. The fixed 10% formalin glomerulus fibrosis examination using Masson trichrome staining. Kidney blood obtained assays associated biochemical parameters. Chronic treatment prevented evidenced by...
To explore new molecular diagnosis approaches for early detection and differential of hepatocellular carcinoma (HCC), we analyzed genomic copy number variations (CNV) using plasma cell-free DNA from patients with HCC by next generation sequencing. Plasma samples 31 8 chronic hepatitis or cirrhosis were analyzed. In group, most large tumor size (tumor dimension greater than 50 mm) showed CNVs that are visually recognizable at chromosome CNV plots, few small none liver diseases plots. Z score...
NUDT15 c.415C>T was a novel genetic marker confirmed in our center for thiopurine-induced leukopenia Chinese inflammatory bowel disease (IBD). For validation, large cohort study is needed. Meanwhile, the newly discovered coding variants (c.36_37insGGAGTC and c.52 G>A) have not been studied patients with IBD. We aimed to further confirm influence of 3 (c.415C>T, c.36_37insGGAGTC, c.52G>A) on Patients prescribed thiopurines at least 2 weeks were recruited from 4 tertiary hospitals. Clinical...
Abstract Accumulating evidence has demonstrated that the enhanced synaptic plasticity of nociceptive interneurons in spinal dorsal horn is basis central sensitization neuropathic pain. Our previous results sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, alleviates pain type 2 diabetes mellitus rats. SIRT1 also been reported to regulate different brain neurons. However, role neurons remains unknown. In this study, we found diabetic (DNP) rats and db/db...
Identification of new biomarkers may help in the early diagnosis inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to analyze untargeted lipidomics and compare plasma lipid profiles between IBD patients control subjects. The principal component analysis partial least-squares-discriminant were carried out distinguish from Using univariate multivariate analysis, 55...
Abstract Chronic pain and anxiety symptoms are frequently encountered clinically, but the neural circuit mechanisms underlying comorbid in (CASP) context of chronic remain unclear. Using viral neuronal tracing mice, we identified a previously unknown pathway whereby glutamatergic neurons from layer 5 hindlimb primary somatosensory cortex (S1) (Glu S1 ), well-known brain region involved processing, project to GABAergic caudal dorsolateral striatum (GABA cDLS ). In persistent inflammatory...