A5113933224- Gastric Cancer Management and Outcomes
- Protein Degradation and Inhibitors
- Cell death mechanisms and regulation
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- Nutrition and Health in Aging
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Diabetes Treatment and Management
- Cancer therapeutics and mechanisms
- Circular RNAs in diseases
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Polyamine Metabolism and Applications
- Receptor Mechanisms and Signaling
- Nanoplatforms for cancer theranostics
Sun Yat-sen University
2014-2025
Sun Yat-sen University Cancer Center
2014-2025
The University of Texas Southwestern Medical Center
2024-2025
Southwestern Medical Center
2024
University of Macau
2022
State Key Laboratory of Oncology in South China
2018-2019
Wuhan Technology and Business University
2019
Xuzhou Medical College
2019
University of South Florida
2014-2015
University of North Carolina at Chapel Hill
1995
The N6-methyladenosine (m6A) modification serves as an essential epigenetic regulator in eukaryotic cells, playing a significant role tumorigenesis and cancer progression. However, the detailed biological functions underlying mechanisms of m6A regulation gastric (GC) are poorly understood. Our research revealed that demethylase ALKBH5 was markedly downregulated GC tissues, which associated with poor patient prognosis. Functional studies demonstrated suppressing expression enhanced cell...
The prognostic value of preoperative controlling nutritional status (CONUT) has been reported in many malignancies. In present study, we aimed to clarify the impact CONUT gastric cancer (GC) receiving curative resection and adjuvant chemotherapy. We retrospectively reviewed 697 consecutive patients undergoing surgery followed by chemotherapy for Stage II-III GC between November 2000 September 2012. Patients were classified into high (≥3) low (≤2) groups according receiver operating...
No antiangiogenic treatment is yet approved for extrapancreatic neuroendocrine tumors (NET). Surufatinib (HMPL-012, previously named sulfatinib) a small-molecule inhibitor targeting vascular endothelial growth factor receptors, fibroblast receptor 1 and colony-stimulating receptor. We conducted single-arm phase Ib/II study of surufatinib in advanced NETs.Patients with histologically well-differentiated, low or intermittent grade, inoperable metastatic NETs were enrolled into pancreatic NET...
Summary Type 2 diabetes mellitus (T2 DM ) is caused by insulin resistance and characterized progressive pancreatic β ‐cell dysfunction. This articles reviews the application limitations of currently approved oral drugs for treatment T2 . Data were retrieved from literature well‐recognized drug‐related databases. Although lifestyle modifications metformin are cornerstones initial management , there an increasing array second‐ third‐line pharmacological agents, including sulphonylureas,...
Abstract: The aberrant expression of human microRNA-181a-1 (hsa-miR-181a) has been implicated in the pathogenesis various cancers, serving as an oncogene or a tumor suppressor. However, role hsa-miR-181a endometrial carcinoma (EC) and its clinical significance are unclear. This study aimed to search for molecular targets using bioinformatic tools then determine levels normal, hyperplasia, EC samples from humans. To predict hsa-miR-181a, ten different algorithms were used, including...
Abstract Accumulating evidence has demonstrated that the enhanced synaptic plasticity of nociceptive interneurons in spinal dorsal horn is basis central sensitization neuropathic pain. Our previous results sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, alleviates pain type 2 diabetes mellitus rats. SIRT1 also been reported to regulate different brain neurons. However, role neurons remains unknown. In this study, we found diabetic (DNP) rats and db/db...
Coagulation and nutrition play important roles in cancer progression. The aim of the present study is to evaluate prognostic value preoperative fibrinogen/albumin ratio (FAR) surgical patients with soft tissue sarcoma (STS) compare this other inflammatory biomarkers. In addition, we investigated relationship between FAR clinicopathological characteristics STS patients.We included 310 retrospective study. Kaplan-Meier curves, univariate multivariate Cox proportional models were used...
Abstract Although messenger RNA translation is tightly regulated to preserve protein synthesis and cellular homeostasis, chronic exposure interferon‐γ (IFN‐γ) in several cancers can lead tryptophan (Trp) shortage via the indoleamine‐2,3‐dioxygenase (IDO)‐ kynurenine pathway therefore promotes production of aberrant peptides by ribosomal frameshifting tryptophan‐to‐phenylalanine (W>F) codon reassignment events (substitutants) specifically at Trp codons. However, effect depletion on...
<p>Table S1. NRAS mutations in leukemia</p>
<div>Abstract<p><i>RAS</i> mutations are prevalent in leukemia, including at G12, G13, T58, Q61, K117, and A146. These often crucial for tumor initiation, maintenance, recurrence. Although much is known about RAS function the last 40 years, a substantial knowledge gap remains understanding mutation-specific biological activities of cancer approaches needed to target specific mutants effectively. The recent approval KRAS<sup>G12C</sup> inhibitors, adagrasib...
<p>Table S3. HRAS mutations in leukemia</p>
<p>Table S2. KRAS mutations in leukemia</p>
ABSTRACT Background Distinctive heterogeneity characterizes diffuse large B‐cell lymphoma (DLBCL), one of the most frequent types non‐Hodgkin's lymphoma. Mitochondria have been demonstrated to be closely involved in tumorigenesis and progression, particularly DLBCL. Objective The purposes this study were identify prognostic mitochondria‐related genes (MRGs) DLBCL, develop a risk model based on MRGs machine learning algorithms. Methods Transcriptome profiles clinical information obtained from...
This issue highlights the development of a first-in-class small-molecule covalent KRASG12C inhibitor, BBO-8520, which targets both active (ON) and inactive (OFF) states KRAS. dual-state targeting offers significant opportunity to overcome resistance mechanisms that have limited efficacy first-generation KRAS inhibitors addresses critical challenges in KRAS-targeted therapy. See related article by Maciag et al., p. 578.
Abstract Purpose To identify how Epstein‐Barr virus (EBV) status combined with molecular profiling predicts the prognosis of gastric cancer patients and their associated clinical actionable biomarkers. Experimental Design A next‐generation sequencing assay targeting 295 cancer‐related genes was performed in 73 EBV‐associated (EBVaGC) 75 EBV‐negative (EBVnGC) specimens these results were compared overall survival (OS). Results PIK3CA , ARID1A SMAD4 PIK3R1 mutated significantly more frequently...
Abstract: Natural compounds are becoming popular for the treatment of illnesses and health promotion, but mechanisms action safety profiles often unknown. Xyloketal B (XKB) is a novel marine compound isolated from mangrove fungus Xylaria sp., with potent antioxidative, neuroprotective, cardioprotective effects. However, its molecular targets effects on drug-metabolizing enzymes This study aimed to investigate potential XKB using bioinformatic approaches examine effect expression activity rat...
Abstract The aim of this study was to improve and validate a more stable less time‐consuming method based on liquid chromatography tandem mass spectrometry (LC‐ MS/MS) for the quantitative measurement imatinib its metabolite N‐ demethyl‐imatinib (NDI) in human plasma. Separation analytes performed Waters XTerra RP 18 column (50 × 2.1 mm i.d., 3.5 μm) with mobile phase consisting methanol–acetonitrile–water (65:20:15, v /v/v) 0.05% formic acid at flow‐rate 0.2 mL/min. Quattro MicroTM triple...