A5060070844- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Pancreatitis Pathology and Treatment
- Lung Cancer Treatments and Mutations
- Adrenal and Paraganglionic Tumors
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Plant-Microbe Interactions and Immunity
- Head and Neck Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MRI in cancer diagnosis
- Bacterial biofilms and quorum sensing
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
Peking Union Medical College Hospital
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Chinese PLA General Hospital
2025
Shanghai Ocean University
2020-2024
Ministry of Agriculture and Rural Affairs
2024
Nanjing University of Chinese Medicine
2024
Creative Commons
2020-2023
Renji Hospital
2023
Shanghai Jiao Tong University
2023
Shanghai Cancer Institute
2023
Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate (ADC) designed to target HER2 mutations. We reported a case study demonstrating favorable response DS-8201 in patient with mutation-positive non-small cell lung cancer (NSCLC) who exhibited resistance initial immunotherapy, along delayed immune-related events of hypoadrenocorticism occurring five months after discontinuation immune checkpoint inhibitors. After reviewing the relevant literature, we discussed mechanism ADC agents...
Radiolabeled somatostatin analog therapy has become an established treatment method for patients with well to moderately differentiated unresectable or metastatic neuroendocrine tumors (NETs). The most frequently used analogs in clinical practice are octreotide and octreotate. However, both peptides showed suboptimal retention within tumors. aim of this first-in-humans study is explore the safety dosimetry a long-acting radiolabeled analog, <sup>177</sup>Lu-1, 4, 7,...
No antiangiogenic treatment is yet approved for extrapancreatic neuroendocrine tumors (NET). Surufatinib (HMPL-012, previously named sulfatinib) a small-molecule inhibitor targeting vascular endothelial growth factor receptors, fibroblast receptor 1 and colony-stimulating receptor. We conducted single-arm phase Ib/II study of surufatinib in advanced NETs.Patients with histologically well-differentiated, low or intermittent grade, inoperable metastatic NETs were enrolled into pancreatic NET...
<sup>68</sup>Ga-DOTA-JR11 is a somatostatin receptor subtype 2–specific antagonist used for PET/CT imaging. The purpose of this study was to compare and <sup>68</sup>Ga-DOTATATE in patients with metastatic, well-differentiated neuroendocrine tumors. <b>Methods:</b> Patients histologically proven, metastatic or unresectable, tumors were prospectively recruited study. Each patient received an intravenous injection (155 ± 52 MBq) on the first day (148 second day. Whole-body scans performed at...
Objective: To establish reference intervals for exophthalmometric values in adults based on MRI method, and to analyze the consistency between obtained via Hertel method patients with thyroid eye disease (TED). Method: A total of 769 who underwent head examination at First Medical Center Chinese PLA General Hospital from April September 2024 were prospectively included as a population, an age [M (Q1, Q3)] 54.0 (39.0, 64.0) years, including 369 males 400 females. The orbital axial T2-weighted...
Paenibacillus polymyxa (formerly known as Bacillus polymyxa) has been extensively studied for agricultural applications a plant-growth-promoting rhizobacterium and is also an important biocontrol agent. Our team developed the P. strain HY96-2 from tomato rhizosphere first microbial biopesticide based on controlling plant diseases around world, leading to commercialization of this in China. However, further research essential understanding its precise mechanisms. In paper, we report complete...
<sup>68</sup>Ga-NODAGA-LM3 (where LM3 is <i>p</i>-Cl-Phe-cyclo(d-Cys-Tyr-d-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)d-Tyr-NH<sub>2</sub>) and <sup>68</sup>Ga-DOTA-LM3 are somatostatin receptor subtype 2 (SSTR2)–specific antagonists used for PET/CT imaging. The purpose of this study was to evaluate the safety, biodistribution, dosimetry in patients with well-differentiated neuroendocrine tumors. <b>Methods:</b> Patients were equally randomized into arms, arm A receiving B <sup>68</sup>Ga-DOTA-LM3....
Objective:177Lu-DOTA-EB-TATE is a theranostic agent based on octreotate that uses an Evans blue structure to bind albumin improve the pharmacokinetics and pharmacodynamics. This pilot study aims evaluate efficacy of single low-dose treatment using 177Lu-DOTA-EB-TATE in patients with advanced neuroendocrine neoplasm (NEN). Methods: With IRB approval informed consent, 4 NEN were enrolled undergo low dose 0.66 ± 0.06 GBq (17.8 1.7 mCi); 3 other as controls 177Lu-DOTA-TATE administered activity...
Early biomarkers of therapeutic responses can help optimize the treatment metastatic colorectal cancers (mCRC). In this prospective exploratory study, we examined serial changes plasma-circulating tumor DNA (ctDNA) in 41 mCRC patients receiving first-line chemotherapies and tested its association with outcomes according to radiological assessments. Using next-generation sequencing technologies, profiled somatic mutations 50 cancer-related genes ctDNA before each first four cycles. We...
Abstract The focus of this study was to investigate the effects luxS , a key regulatory gene autoinducer-2 (AI-2) quorum sensing (QS) system, on biofilm formation and biocontrol efficacy against Ralstonia solanacearum by Paenibacillus polymyxa HY96-2. mutants were constructed assayed for wild-type (WT) strain P. HY96-2 in vitro vivo . results showed that positively regulated Greenhouse experiments tomato bacterial wilt found from early stage late postinoculation, deletion lowest with 50.70 ±...
Digestive system neuroendocrine carcinomas (NECs) are rare neoplasms originating from cells with a poor prognosis and limited effective treatments. Programmed cell death protein 1/ligand 1 (PD-1/PD-L1) blockade has been used in the management of more than 10 solid tumors achieved promising clinical outcomes. PD-L1 expression, immune infiltration, tumor mutational burden (TMB), microsatellite instability (MSI) all verified biomarkers that can predict response to anti-PD-1/PD-L1 therapy. Here,...
Contrast-enhanced ultrasound (CEUS) is a promising imaging modality in predicting the efficacy of neoadjuvant chemotherapy for pancreatic cancer, tumor with high mortality. In this study, we proposed deep-learning-based strategy analyzing CEUS videos to predict prognosis cancer chemotherapy. Pre-trained convolutional neural network (CNN) models were used binary classification as effective or ineffective, collected before model input, and after reference standard. We two deep learning models....
This study aimed to evaluate the safety and efficacy of multiple cycles <sup>177</sup>Lu-DOTA-Evans blue (EB)-TATE peptide receptor radionuclide therapy (PRRT) at escalating doses in neuroendocrine tumors (NETs). <b>Methods:</b> Thirty-two NET patients were randomly divided into 3 groups treated with doses. Group A received 1.17 ± 0.09 GBq/cycle; group B, 1.89 0.53 C, 3.97 0.84 GBq/cycle. The treatment was planned for up cycles. Treatment-related adverse events graded according National...
There are no standard third-line treatment options for metastatic pancreatic ductal adenocarcinoma (mPDAC). Trametinib in combination with hydroxychloroquine (HCQ) or CDK4/6 inhibitors showed promising efficacy preclinical studies. However, the regimens have not been well examined patients mPDAC.Patients mPDAC who received of trametinib and HCQ as third- later-line therapy were reviewed. The prognosis further analyzed.A total 13 enrolled, whom 8 5 treated plus a inhibitor (palbociclib...
Grass Carp Reovirus (GCRV) and Aeromonas hydrophila (Ah) are the causative agents of haemorrhagic disease in grass carp. This study aimed to investigate molecular mechanisms immune responses at miRNA, mRNA, protein levels carp kidney cells (CIK) infected by (GCRV, NV) hydrophilus (Bacteria, NB) gain insight into their pathogenesis. Within 48 h infection with (GCRV), 99 differentially expressed microRNA (DEMs), 2132 genes (DEGs), 627 proteins (DEPs) were identified sequencing; a total 92...
Circulating chromogranin A (CgA) level is a useful marker for diagnosis and treatment efficacy monitoring of neuroendocrine tumors (NETs). To evaluate the diagnostic value serum CgA in well-differentiated non-functioning NETs to investigate correlation between changes levels imaging responses patients with locally advanced or metastatic disease, 60 healthy controls 82 (28 localized 54 NETs) treated December 2010 November 2014 were included. determined by ELISA. Receiver-operating...