A5036744599- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Neuroblastoma Research and Treatments
- Esophageal Cancer Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Gastrointestinal disorders and treatments
- Extracellular vesicles in disease
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Intraperitoneal and Appendiceal Malignancies
- Lymphoma Diagnosis and Treatment
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
State Key Laboratory of Oncology in South China
2015-2024
First Affiliated Hospital of Guangdong Pharmaceutical University
2024
Jiangxi Agricultural University
2024
Shenzhen Luohu People's Hospital
2023-2024
Peking University
2024
Peking University Cancer Hospital
2024
Fujian Medical University
2023
First Affiliated Hospital of Fujian Medical University
2023
Abstract China is one of the countries with highest incidence gastric cancer. There are differences in epidemiological characteristics, clinicopathological features, tumor biological treatment patterns, and drug selection between cancer patients from Eastern Western countries. Non‐Chinese guidelines cannot specifically reflect diagnosis characteristics for Chinese patients. The Society Clinical Oncology (CSCO) arranged a panel senior experts specializing all sub‐specialties to compile,...
There exist differences in the epidemiological characteristics, clinicopathological features, tumor biological treatment patterns, and drug selections between gastric cancer patients from Eastern Western countries. The Chinese Society of Clinical Oncology (CSCO) has organized a panel senior experts specializing all sub-specialties to compile clinical guideline for diagnosis since 2016 renews it annually. Taking into account regional differences, giving full consideration accessibility...
We postulated that the ImmunoScore (IS) could markedly improve prediction of postsurgical survival and chemotherapeutic benefits in gastric cancer (GC).A model for GC patients was developed using data from 879 consecutive patients.The expression 27 immune features detected 251 specimens by immunohistochemistry, a 5-feature-based ISGC then constructed LASSO Cox regression model. Testing validation cohorts were included to validate model.Using model, we established an classifier based on 5...
Abstract The 2023 update of the Chinese Society Clinical Oncology (CSCO) Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China, reflecting latest advancements evidence‐based medicine, healthcare resource availability, precision medicine. These updates address differences epidemiological characteristics, clinicopathological features, tumor biology, patterns, drug selections between Eastern Western gastric patients. Key revisions include a structured...
To develop and validate a radiomics signature for the prediction of gastric cancer (GC) survival chemotherapeutic benefits. In this multicenter retrospective analysis, we analyzed features portal venous-phase computed tomography in 1591 consecutive patients. A was generated by using Lasso-Cox regression model 228 patients validated internal external validation cohorts. Radiomics nomograms integrating were constructed, demonstrating incremental value to traditional staging system...
Early surgery is vital in the treatment of pancreatic cancer, which often fatal. However, there currently no useful noninvasive biomarker to screen for cancer. Studies have documented that many salivary molecules can be used detect systemic diseases. We investigated whether miRNAs are biomarkers detecting resectable Using an Agilent microarray, were profiled from saliva samples 8 patients with cancer and healthy controls. Candidate identified profiles subjected validation using quantitative...
The current study aimed to establish a novel nomogram predict the overall survival of individual Chinese patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Furthermore, this sought externally validate using Surveillance, Epidemiology, and End Results (SEER) database. records 1183 GEP-NENs treated at five high-capacity institutions in China between 2005 2015 were retrospectively analysed. In addition, 10 236 GEP-NEN cases from SEER database included as an external...
The hematogenous metastatic pattern of gastric cancer (GC) was not fully explored. Here we analyzed the frequency and clinicopathological features metastasis to liver, lung, bone, brain from GC patients. Data queried for this analysis included patients Surveillance, Epidemiology, End Results Program database 2010 2014. All statistical analyses were performed using Intercooled Stata 13.0 (Stata Corporation, College Station, TX). tests two-sided. Totally, there 19 022 eligible analysis. At...
<h3>Importance</h3> Occult peritoneal metastasis frequently occurs in patients with advanced gastric cancer and is poorly diagnosed currently available tools. Because the presence of precludes possibility curative surgery, there an unmet need for a noninvasive approach to reliably identify occult metastasis. <h3>Objective</h3> To assess use deep learning model predicting based on preoperative computed tomography images. <h3>Design, Setting, Participants</h3> In this multicenter,...
<h3>Importance</h3> Neoadjuvant therapies have been shown to decrease tumor burden, increase resection rate, and improve the outcomes among patients with locally advanced gastric cancer (GC). However, not all are equally responsive; therefore, differentiating potential respondents from nonrespondents is clinically important. <h3>Objective</h3> To use pretreatment computed tomography (CT)–pixelated feature-difference extraction techniques identify diagnostically relevant features that could...
Objective: A large-scale multicenter retrospective cohort study was conducted to compare the short- and long-term outcomes of robotic gastrectomy (RG) laparoscopic (LG) for gastric cancer. Summary Background Data: RG is being increasingly used worldwide, but data from studies on oncologic versus LG are limited. The potential benefits compared with cancer remain controversial. Methods: Data eligible patients who underwent or 11 experienced surgeons 7 centers in China between March 2010...
The preoperative neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte (PLR) are associated with poor prognosis of gastric cancer. We aimed to determine whether combination NLR PLR (NLR–PLR) could better predict survival patients after curative resection for stage I–II collected data from medical records cancer undergoing between December 2000 November 2012 at Sun Yat-sen Cancer Center. NLR–PLR was calculated as follows: both elevated (≥2.1) (≥120) were given a score 2, only...
Epstein-Barr virus (EBV)-associated gastric carcinomas (EBVaGCs) may account for 8-9% of all cancer (GC) patients. All previous reports on EBVaGC were retrospective. Prospective study is warranted to evaluate the exact role EBV status in predicting prognosis GC. It special interest figure out whether dynamic detection plasma EBV-DNA load could be a feasible biomarker monitor EBVaGC. From October 2014 September 2017, we consecutively collected GC patients (n = 2,760) from Sun Yat-sen...
Background: To evaluate whether radiomic feature-based computed tomography (CT) imaging signatures allow prediction of lymph node (LN) metastasis in gastric cancer (GC) and to develop a preoperative nomogram for predicting LN status. Methods: We retrospectively analyzed radiomics features CT images 1,689 consecutive patients from three centers. The model was developed the training cohort validated internal external validation cohorts. Lasso regression utilized select build signature....
Lymph node metastasis (LNM) in gastric cancer is a prognostic factor and has implications for the extent of lymph dissection. The lymphatic drainage stomach involves multiple nodal stations with different risks metastases. aim this study was to develop deep learning system predicting LNMs based on preoperative CT images patients cancer.Preoperative from who underwent gastrectomy dissection at two medical centres were analysed retrospectively. Using discovery patient cohort, convolutional...
Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined. This study aimed to finely characterize dynamic immune contexture of human EBV (+) GC treated with immunochemotherapy by longitudinal scRNA-seq paired scTCR/BCR-seq. exhibits inflamed-immune phenotype increased T-cell B-cell infiltration. Immunochemotherapy triggers clonal revival...
4001 Background: The combination of PD-1 antibody and chemotherapy was shown to be effective in advanced gastric or gastro-oesophageal junction (GEJ) cancer, but has not yet been investigated the context locally patients. In this study, we conducted a prospective, randomized, open-label phase II trial evaluate effectiveness adding perioperative patients with resectable GEJ cancer. Methods: open-label, cancer clinically staged as cT3-4a N+M0 were randomized (1:1) three preoperative five...