A5101756083- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- FOXO transcription factor regulation
- Metastasis and carcinoma case studies
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- Sulfur Compounds in Biology
- HER2/EGFR in Cancer Research
- RNA Research and Splicing
- Heat shock proteins research
- Chemotherapy-induced cardiotoxicity and mitigation
- Macrophage Migration Inhibitory Factor
- CAR-T cell therapy research
- Galectins and Cancer Biology
- Pregnancy-related medical research
Affiliated Hospital of North Sichuan Medical College
2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Zhongshan Hospital
2015-2024
Sun Yat-sen University
2015-2024
Fudan University
2015-2024
Xian Central Hospital
2024
Harbin Medical University
2022-2024
Second Affiliated Hospital of Harbin Medical University
2022-2024
Rosalind Franklin University of Medicine and Science
2024
New York University
2024
Abstract China is one of the countries with highest incidence gastric cancer. There are differences in epidemiological characteristics, clinicopathological features, tumor biological treatment patterns, and drug selection between cancer patients from Eastern Western countries. Non‐Chinese guidelines cannot specifically reflect diagnosis characteristics for Chinese patients. The Society Clinical Oncology (CSCO) arranged a panel senior experts specializing all sub‐specialties to compile,...
Gastric cancer (GC) is a common disease globally with high mortality rate. It therefore necessary to develop novel therapies targeting specific events in the pathogenesis of GC. Some hnRNP family members are involved multiple biological behaviors. However, potential function and mechanism hnRNPR, new molecule GC remains unknown. We found that expression hnRNPR was significantly overexpressed cancers compared normal tissues. Functionally, promoted cell proliferation, migration, invasion....
Patient-derived organoids and xenografts (PDXs) have emerged as powerful models in functional diagnostics with high predictive power for anticancer drug response. However, limitations such engraftment failure time-consuming establishing expanding PDX followed by testing efficacy, inability to subject systemic administration ex vivo organoid culture hinder realistic fast decision-making selecting the right therapeutics clinic. The present study aimed develop an advanced model, namely MiniPDX,...
Chemoresistance is a main obstacle in gastric cancer (GC) treatment, but its molecular mechanism still needs to be elucidated. Here, we aim reveal the underlying mechanisms of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) resistance GC.We performed RNA sequencing (RNA-seq) on samples from patients who were resistant or sensitive nab-paclitaxel, and identified Zinc Finger Protein 64 (ZFP64) as critical for nab-paclitaxel GC. CCK8, flow cytometry, TUNEL staining, sphere formation...
// Qian Li 1, * , Huiqin Jiang Hong Ruihua Xu 2 Lin Shen 3 Yiyi Yu 1 Yan Wang Yuehong Cui Wei Shan Tianshu Liu Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China Sun Yat-Sen University Cancer Center; State Key Laboratory Oncology in South China, Guangzhou, Gastrointestinal Carcinogenesis and Translational Research (Ministry Education), Peking Hospital Institute, Beijing, These authors have contributed equally to this work Correspondence to: Liu, email:...
Forkhead box O3A (FOXO3a) is an important transcription factor involved in various human cancers. However, the role of FOXO3a regulating invasion and metastasis gastric cancer cells has not been clarified. Here, we report that overexpression promoted migration by upregulating cathepsin L. knockdown suppressed also downregulated L expression cells. Silencing these overexpression-induced cell invasion. Mechanistic studies revealed increased promoter activation, repressed E-cadherin expression,...
BACKGROUND:Cancer immunotherapy is the use of immune system to treat cancer. After years research, there have been a significant number publications in this field. We analyzed literature and performed hotspot analysis identify important areas future scientific research. MATERIAL AND METHODS:Articles (2945) related cancer published past 3 were selected as research sample. BICOMB software was then used retrieve high-frequency words construct text/co-word matrix. Next, gCLUTO analyze matrix by...
Abstract Posttraumatic widespread pain (PTWP) and posttraumatic stress symptoms (PTSS) are frequent comorbid sequelae of trauma that occur at different rates in women men. We sought to identify microRNA (miRNA) may contribute sex-dependent differences vulnerability these outcomes. Monte Carlo simulations (x10,000) identified miRNA which predicted targeting PTWP or PTSS genes was most enriched. Expression the leading candidate target PTWP/PTSS-related genes, miR-19b, has been shown be...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Magnetic Susceptibilities of Some Aromatic Hydrocarbon Anions1a,bTing Li Chu and Shan Chi YuCite this: J. Am. Chem. Soc. 1954, 76, 13, 3367–3369Publication Date (Print):July 1, 1954Publication History Published online1 May 2002Published inissue 1 July 1954https://pubs.acs.org/doi/10.1021/ja01642a004https://doi.org/10.1021/ja01642a004research-articleACS PublicationsRequest reuse permissionsArticle Views650Altmetric-Citations27LEARN ABOUT THESE...
Immunotherapy confers little to no benefit in the treatment of microsatellite stable (MSS) metastatic colorectal cancer (mCRC). Mechanistic insights suggested that epidermal growth factor receptor (EGFR) antibody plus irinotecan might augment tumor immune response mCRC. Therefore, we conducted a proof-of-concept, single-arm, phase 2 study (ChiCTR identifier: ChiCTR2000035642) combination regimen including tislelizumab (anti-PD-1), cetuximab (anti-EGFR) and 33 patients with MSS RAS wild-type...
Co-morbid chronic musculoskeletal pain (CMSP) and posttraumatic stress symptoms (PTSS) are frequent sequelae of motor vehicle collision, associated with greater disability than either outcome alone, more prevalent in women men. In the current study we assessed for evidence that gene transcripts originating from X chromosome contribute to sex differences vulnerability CMSP PTSS after collision. Nested samples were drawn a longitudinal African American individuals, (0-10 numeric rating scale)...
Resistance to epidermal growth factor receptor (EGFR) targeted monoclonal antibody therapy represents a clinical challenge in patients suffered from RAS wild-type (WT) metastatic colorectal cancer (mCRC). However, the molecular mechanisms and key factors conferring this resistance are largely unknown. Forkhead transcription of O class 3a (FoxO3a), an important regulator cell survival, has been reported with dual functions tumor recently. In study, we found that FoxO3a was highly expressed...
Different subtypes of gastric cancer differentially respond to immune checkpoint inhibitors (ICI). This study aimed investigate whether the Estimation STromal and Immune cells in Malignant Tumor tissues using Expression data (ESTIMATE) algorithm is related classification prognosis establish an ESTIMATE-based gene signature predict for patients. The immune/stromal scores 388 patients from TCGA were used this analysis. upregulated expressed genes (DEGs) with high stromal/immune identified....