A5101652227- Cardiac Ischemia and Reperfusion
- Platelet Disorders and Treatments
- Mitochondrial Function and Pathology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sirtuins and Resveratrol in Medicine
- Ion channel regulation and function
- Phytoestrogen effects and research
- Occupational and environmental lung diseases
- Neonatal Respiratory Health Research
- FOXO transcription factor regulation
- Pleural and Pulmonary Diseases
- Spinal Cord Injury Research
- Neuroscience and Neuropharmacology Research
- Cystic Fibrosis Research Advances
- Autophagy in Disease and Therapy
- Reconstructive Facial Surgery Techniques
- Optical Imaging and Spectroscopy Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Urological Disorders and Treatments
- Inflammation biomarkers and pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood donation and transfusion practices
- Estrogen and related hormone effects
- Calpain Protease Function and Regulation
Eastern Liaoning University
2024
North China University of Science and Technology
2008-2021
Shanxi Academy of Agricultural Sciences
2021
Hospital of Hebei Province
2020
Shaanxi Provincial People's Hospital
2018
Shanxi Medical University
2018
University of South China
2014-2015
Tokai University
2015
Jilin University
2014
TED University
2011-2013
Avatrombopag, an oral thrombopoietin receptor agonist, was compared with placebo in a 6-month, multicentre, randomised, double-blind, parallel-group Phase 3 study, open-label extension phase, to assess the efficacy and safety of avatrombopag (20 mg/day) adults chronic immune thrombocytopenia (ITP) platelet count <30 × 109 /l (ClinicalTrials.gov identifier NCT01438840). The primary endpoint cumulative number weeks response (platelet ≥50 /l) without rescue therapy for bleeding; secondary...
Alzheimer's disease is a neurodegenerative disorder associated with the deposition of peptide amyloid-beta (Aβ) in senile plaques and cerebral vasculature. The neurotoxic mechanisms this condition have been linked to oxidative-stress-induced apoptosis leading widespread neuronal loss. Herein, we demonstrate neuroprotective effects ketone body D-β-hydroxybutyrate (β-HB) neural cell lines an animal model induced by injecting Aβ into hippocampus. Using histological examination TUNEL assay, show...
The aim of this study was to test whether morphine prevents the mitochondrial permeability transition pore (mPTP) opening through Zn 2+ and glycogen synthase kinase 3β (GSK-3β). Fluorescence dyes including Newport Green Dichlorofluorescein (DCF), 4-amino-5-methylamino-2′,7′-difluorofluorescein (DAF-FM), tetramethylrhodamine ethyl ester (TMRE) were used image free , nitric oxide (NO), membrane potential (ΔΨ m ), respectively. images obtained with confocal microscopy. Cardiomyocytes treated...
Objective To evaluate the biological effects of selective cyclooxygenase‐2 inhibition on prostate tissue in patients undergoing radical prostatectomy ( RP ). Patients and Methods with localised cancer were randomised to receive either celecoxib 400 mg twice daily or placebo for 4 weeks before . Specimens analysed levels apoptosis, prostaglandins, androgen receptor AR Effects serum prostate‐specific antigen PSA ) postoperative opioid use also measured. Results In all, 28 44 anticipated...
Lipopolysaccharide (LPS)-induced endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. LCZ696, dual-acting angiotensin receptor blocker, and neprilysin inhibitor has been used for treatment heart failure with reduced ejection fraction. Recent work suggests that LCZ696 therapy might have anti-inflammatory effect tissue. In current study, we show attenuates LPS-induced oxidative stress by reducing production intracellular reactive oxygen species (ROS)...
Thrombocytopenia complicates the management of patients with chronic liver disease (CLD) undergoing invasive procedures a bleeding risk. Until recently, prophylactic platelet transfusion was only treatment option, but has significant safety and efficacy limitations. Phase 3 data demonstrated superiority avatrombopag to placebo in reducing transfusions for bleeding, supporting its recent approval.Integrated analyses pooled (N = 435) from two randomized, double-blind, placebo-controlled, phase...
ABSTRACT Objective : Although several methods have been used to detect the intracellular reactive oxygen species (ROS) generation, it is still difficult determine where ROS generate from. This study aimed demonstrate whether from mitochondria during oxidative stress induced damage in cardiac H9c2 cells by laser scanning confocal microscopy (LSCM). Methods Cardiac were exposed H 2 O (1200μM) induce mitochondrial oxidant damage. Mitochondrial membrane potential (ΔΨm) was measured staining with...
As China's economy enters the 'new normal' operational stage, widespread adoption of Public-Private Partnership (PPP) model has engendered substantial transformations in infrastructure investment and financing practices, progressively moving towards standardization. This study employs indicators such as Research Development (R&D) investments number patents held by publicly listed companies to assess their innovation performance. Employing a Differences-in-Differences (DID) empirical...
Resveratrol is a polyphenolic compound found in wine, which mainly produced by the grapevine and exerts chemopreventive effects against hepatocellular carcinoma. However, underlying molecular mechanisms have remained to be fully elucidated. The present study assessed whether resveratrol-induced apoptosis was mediated via activation of forkhead box O3a (FoxO3a) transcription factor. It demonstrated that resveratrol treatment induced HepG2 cells, this pro‑apoptotic effect accompanied with...
Aims: The purpose of this study was to determine if ethanol prevents the mitochondrial permeability transition pore (mPTP) opening via glycogen synthase kinase 3β (GSK-3β). Methods: Cardiac H9c2 cells were exposed (10–1000 μM) for 20 min. GSK-3β activity determined by measuring its phosphorylation at Ser9. Mitochondrial membrane potential (ΔΨm) assessed imaging (confocal microscopy) loaded with tetramethylrhodamine ethyl ester (TMRE). To activate GSK-3β, transfected constitutively active...
In the aging society, elder people commonly suffer cancer, which is associated with increased rates of fractures due to osteoporosis from cancer. present study, prevalence prostatic so-called "latent adenocarcinoma", investigated among forensic autopsy cases. Retrospective histo-pathology was performed on 114 subjects (61.8 ± 13.3 years old). Forth-four specimens (38.6%) harbored carcinomas Gleason combined scores ranging 3 9. The detection rate in accordance age, highest (8/13, 61.5%)...
To explore the role of mitochondrial permeability transition pore (mPTP) in mediating protective effect gastrodin against oxidative stress damage H9c2 cardiac myocytes.H9c2 myocytes were treated with H2O2, gastrodin, gastrodin+H2O2, cyclosporin A (CsA), or CsA+gas+H2O2 group. MTT assay was used to detect survival ratio cells, and flow cytometry Annexin V-FITC/PI double staining analyze early apoptosis rate after treatments. The concentration ATP level reactive oxygen species (ROS) cells...
<h3>Objectives Aims</h3> We previously documented that morphine upregulates Akt activity by inactivating protein Ser/Thr phosphatases via reactive oxygen species (ROS) may contribute to the protective effect of on ischaemia/reperfusion injury, but molecular mechanism underlying morphine-induced ROS production remains be defined. Since receptor tyrosine kinases (RTKs) cardiac protection induced activation opioid, bradykinin, or muscarinic receptors and could increase intracellular production,...
CF lung disease arises from ion transport defect. Disease origins in small airways before 1 yr of age necessitate early intervention. Denufosol (DEN), a novel chloride channel activator, stimulates Cl − transport, inhibits Na + absorption and increases ciliary beat frequency. A Phase 3, double‐blind, placebo (PL)‐controlled trial (TIGER‐1) was conducted 352 pts to compare inhaled DEN 60 mg TID PL for 24 wks. Pts were ≥ 5 yrs (mean 14.6 yrs) had FEV 75% predicted 92%). Pulmonary function...