A5000491999- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Cardiac electrophysiology and arrhythmias
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nitric Oxide and Endothelin Effects
- Adenosine and Purinergic Signaling
- Heart Failure Treatment and Management
- Cancer, Hypoxia, and Metabolism
- Ion channel regulation and function
- Phosphodiesterase function and regulation
- Traditional Chinese Medicine Analysis
- Cardiac Fibrosis and Remodeling
- Atrial Fibrillation Management and Outcomes
- Receptor Mechanisms and Signaling
- Phytochemistry and Biological Activities
- Bipolar Disorder and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Eicosanoids and Hypertension Pharmacology
- Radio Wave Propagation Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Optical Wireless Communication Technologies
- Synthesis of Tetrazole Derivatives
- Connexins and lens biology
Nankai University
2012-2025
Yanbian University
2012-2024
Advanced Laser Technology (United Kingdom)
2024
University of Science and Technology of China
2024
Hohai University
2024
South Central Minzu University
2022
Capital Normal University
2020
Yanbian University Hospital
2020
Center for Special Minimally Invasive and Robotic Surgery
2018
Robotic Technology (United States)
2018
Lead (Pb), a heavy metal environmental pollutant, poses threat to the health of humans and birds. Inflammation is one most common pathological phenomena in case illness poisoning. However, underlying mechanisms inflammation remain unclear. The cerebellum thalamus are important parts nervous system. To date, there have been no reports Pb inducing animal cerebellums or thalami. Selenium (Se) can relieve Therefore, we aimed explore mechanism by which Se alleviates toxicity thalami chickens...
In the context of low-carbon transformation, manufacturing enterprises are facing great pressures, and they need to improve their capability in order successfully respond these changes achieve sustainable development. Based on concept organizational resilience, this paper proposed carbon representing ability an organization keep stable, adapt, evolve transformation tried explore role resilience enterprises’ environment, social, governance performance (ESG performance) conditional roles...
The purpose of the present experiments was to define role C-type natriuretic peptide (CNP) in regulation atrial secretion (ANP) and stroke volume. Experiments were performed perfused beating nonbeating quiescent atria, single myocytes, membranes. CNP suppressed a dose-related fashion increase volume ANP induced by pacing. caused right shift positive relationships between changes or translocation extracellular fluid (ECF), which indicates suppression myocytic release into paracellular space....
This study tests the hypothesis that particulate (p) guanylyl cyclase (GC) and soluble (s) GC are involved in distinct roles for regulation of cGMP-PDE-cAMP signaling mechanical secretory functions heart. Experiments were performed perfused beating rabbit atria. C-type natriuretic peptide (CNP) SIN-1, an NO donor, or BAY 41-2272 (BAY), a direct activator sGC, used to activate pGC respectively. CNP SIN-1 increased cGMP cAMP efflux concentration-dependent manner. Increase was function cGMP....
Purpose Previous research has yielded inconsistent findings of the effects that task conflict on creative outcomes, with some finding a negative relationship but others holding positive or even no significant relationship. Drawing too-much-of-a-good-thing effect approach, this paper aims to investigate curvilinear relations between and idea generation as well mediating role reflexivity moderating complexity. Design/methodology/approach Two studies were carried out test proposed In Study 1,...
Regulation of atrial release natriuretic peptide (ANP) is coupled to changes in dynamics. However, the mechanism by which mechanical stretch controls myocytic ANP must be defined. The purpose this study was define cAMP perfused, beating rabbit atria. cAMP-elevating agents forskolin and 3-isobutyl-1-methylxanthine (IBMX) inhibited release. activation adenylyl cyclase with release, a function an increase production. Inhibitors for L-type Ca(2+) channels protein kinase A (PKA) attenuated minor...
Atrial secretion of atrial natriuretic peptide (ANP) has been shown to be regulated by workload. Although modulating factors for the ANP have reported, role intracellular Ca 2+ on controversial. The purpose present study was define roles L- and T-type channels in regulation perfused beating rabbit atria. BAY K 8644 (BAY K) increased stroke volume pulse pressure. suppressed concentration terms extracellular fluid (ECF) translocation concomitantly with an increase dynamics. shifted...
Allergic disease is caused by exposure to normally innocuous substances that activate mast cells. Mast cell-mediated allergic inflammation closely related a number of disorders, such as anaphylaxis, rhinitis, asthma and atopic dermatitis. The discovery drugs for treating an interesting subject important human health. aim the present study was investigate anti‑allergic anti-inflammatory effects aqueous extract Pogostemon cablin (Blanco) Benth (AEPC) (a member Labiatae family) using cells,...
Two series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted benzylpiperazine moieties have been synthesized evaluated for their positive inotropic activity by measuring left atrium stroke volume on isolated rabbit heart preparations. The majority the exhibited better in vitro than existing drug, milrinone, 6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)tetrazolo[5,1-a]phthalazine. 8 m particular was identified as most potent with an increased...
While nitric oxide (NO) induces cardioprotection by targeting the mitochondrial permeability transition pore (mPTP), precise signaling events that mediate action of NO remain unclear. The purpose this study was to test whether against ischemia/reperfusion inhibiting oxidative stress through zinc and Src tyrosine kinase. donor S-nitroso-N-acetyl penicillamine (SNAP) given before onset ischemia reduced cell death in rat cardiomyocytes subjected simulated ischemia/reperfusion, abolished...
Abstract To investigate wavefront aberrations in the entire eye and internal optics (lens) retinal image qualities according to different lenticular opacity types densities. Forty-one eyes with nuclear cataract, 33 cortical 29 posterior subcapsular cataract were examined. In each group, quality measured using a raytracing aberrometer. Eyes cataracts showed significantly higher coma-like compared other two groups both optic ( P = 0.012 0.007, respectively). had lower spherical-like than <...
In this study, four novel series of 4-phenyl-1H-1,2,4-triazol-5(4H)-one derivatives containing triazole or piperazine moieties were designed, synthesized, and evaluated for negative inotropic activity by measuring the left atrium stroke volume in isolated rabbit heart preparations. Almost all compounds showed an ability to moderate cardiac workload decreasing rate contractility. Among them, 7h was found be most potent with a change -48.22 ± 0.36% at concentration 3 × 10-5 mol/L (metoprolol:...